DegronMD

Uniprot ID: Q07912

Source protein: Activated CDC42 kinase 1

Source gene: TNK2

Class: DEG_SIAH_1

Location: 904:912

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9894

ASA_SCORE: 87.6222

COIL: 0.9381

CONS_SCORE: 0.4449

DSS_SCORE: 0.7072

HELIX: 0.0276

FCONS_SCORE: 1.3462

RIG_SCORE: 0.6657

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A906P	TCGA-49-AAR9	LUAD	TCGA	APTATVRPM	DEG_SIAH_1	0.7503
p.P914S	TCGA-78-8640	LUAD	TCGA	APTATVRPM	DEG_SIAH_1	0.2778
p.A906T	TCGA-CK-4951	COAD	TCGA	APTATVRPM	DEG_SIAH_1	0.7139
p.Q909K	TCGA-EE-A2GI	SKCM	TCGA	APTATVRPM	DEG_SIAH_1	0.6944
p.P920L	TCGA-QG-A5YX	COAD	TCGA	APTATVRPM	DEG_SIAH_1	0.2222
p.A921T	DO44166	BRCA	ICGC	APTATVRPM	DEG_SIAH_1	0.0833
p.A921D	DO44166	BRCA	ICGC	APTATVRPM	DEG_SIAH_1	0.0833
p.T899P	DO227410	EOPC	ICGC	APTATVRPM	DEG_SIAH_1	0.1944
p.P895S	DO23590	LUAD	ICGC	APTATVRPM	DEG_SIAH_1	0.0833
p.A921S	DO26504	LUSC	ICGC	APTATVRPM	DEG_SIAH_1	0.0833
p.K920R	DO50291	SKCM	ICGC	APTATVRPM	DEG_SIAH_1	0.2222
p.P905L	DO51301	SKCM	ICGC	APTATVRPM	DEG_SIAH_1	0.7582
p.A901V	DO47873	STAD	ICGC	APTATVRPM	DEG_SIAH_1	0.25
p.K920T	DO43755	UCEC	ICGC	APTATVRPM	DEG_SIAH_1	0.2222
p.R917W	SIDM00217	Colorectal Carcinoma	GDSC	APTATVRPM	DEG_SIAH_1	0.1944
p.R917W	SNU-1040	large_intestine	COSMIC	APTATVRPM	DEG_SIAH_1	0.1944
p.T907N	SIDM00976	Melanoma	GDSC	APTATVRPM	DEG_SIAH_1	0.7055
p.R910Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	APTATVRPM	DEG_SIAH_1	0.6218
p.R909C	SNU-283	large_intestine	COSMIC	APTATVRPM	DEG_SIAH_1	0.8301
p.R909C	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	APTATVRPM	DEG_SIAH_1	0.8301
p.P898S	MFE-319	endometrium	COSMIC	APTATVRPM	DEG_SIAH_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07912	Activated CDC42 kinase 1	DEG_SIAH_1	904:912	APTATVRPM	SIAH1,SIAH2,SIAH3	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons