DegronMD

Uniprot ID: O15417

Source protein: Trinucleotide repeat-containing gene 18 protein

Source gene: TNRC18

Class: DEG_APCC_DBOX_1

Location: 2765:2773

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7157

ASA_SCORE: 104.8444

COIL: 0.656

CONS_SCORE: 0.4088

DSS_SCORE: 0.5345

HELIX: 0.3316

FCONS_SCORE: 0.9026

RIG_SCORE: 0.7422

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N2774S	TCGA-B7-5816	STAD	TCGA	KRQRLPSVE	DEG_APCC_DBOX_1	0.3056
p.N2774S	DO38599	STAD	ICGC	KRQRLPSVE	DEG_APCC_DBOX_1	0.3056
p.N2774S	SIDM00480	Ovarian Carcinoma	GDSC	KRQRLPSVE	DEG_APCC_DBOX_1	0.3056
p.N2774S	SIDM01088	Endometrial Carcinoma	GDSC	KRQRLPSVE	DEG_APCC_DBOX_1	0.3056
p.N2774S	ACH-000704	Ovarian Cancer	CCLE	KRQRLPSVE	DEG_APCC_DBOX_1	0.3056
p.N2774S	ACH-000965	Endometrial/Uterine Cancer	CCLE	KRQRLPSVE	DEG_APCC_DBOX_1	0.3056
p.N2774S	OAW-42	ovary	COSMIC	KRQRLPSVE	DEG_APCC_DBOX_1	0.3056
p.N2774S	RL95-2	endometrium	COSMIC	KRQRLPSVE	DEG_APCC_DBOX_1	0.3056
p.A2780T	TCGA-DI-A0WH	UCEC	TCGA	KRQRLPSVE	DEG_APCC_DBOX_1	0.1389
p.A2780T	DO43843	UCEC	ICGC	KRQRLPSVE	DEG_APCC_DBOX_1	0.1389
p.R2766Q	TCGA-EC-A24G	UCEC	TCGA	KRQRLPSVE	DEG_APCC_DBOX_1	0.7329
p.R2766Q	DO40996	UCEC	ICGC	KRQRLPSVE	DEG_APCC_DBOX_1	0.7329
p.R2775W	TCGA-EO-A22U	UCEC	TCGA	KRQRLPSVE	DEG_APCC_DBOX_1	0.2778
p.R2775W	DO43755	UCEC	ICGC	KRQRLPSVE	DEG_APCC_DBOX_1	0.2778
p.A2779T	TCGA-FI-A2D0	UCEC	TCGA	KRQRLPSVE	DEG_APCC_DBOX_1	0.1667
p.A2779T	DO43891	UCEC	ICGC	KRQRLPSVE	DEG_APCC_DBOX_1	0.1667
p.R2768H	ACH-000928	Endometrial/Uterine Cancer	CCLE	KRQRLPSVE	DEG_APCC_DBOX_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15417	Trinucleotide repeat-containing gene 18 protein	DEG_APCC_DBOX_1	2765:2773	KRQRLPSVE	APC,CDC20,FZR1	0.7157	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons