DegronMD

Uniprot ID: O15417

Source protein: Trinucleotide repeat-containing gene 18 protein

Source gene: TNRC18

Class: DEG_APCC_DBOX_1

Location: 1414:1422

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6014

ASA_SCORE: 65.2778

COIL: 0.5103

CONS_SCORE: 0.3813

DSS_SCORE: 0.2554

HELIX: 0.4604

FCONS_SCORE: 1.189

RIG_SCORE: 0.7456

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1404D	TCGA-EK-A2PG	CESC	TCGA	ARPSLESLL	DEG_APCC_DBOX_1	0.0556
p.E1404D	DO49939	CESC	ICGC	ARPSLESLL	DEG_APCC_DBOX_1	0.0556
p.E1404D	SIDM00834	Colorectal Carcinoma	GDSC	ARPSLESLL	DEG_APCC_DBOX_1	0.0556
p.R1410Q	TCGA-FI-A2D5	UCEC	TCGA	ARPSLESLL	DEG_APCC_DBOX_1	0.2222
p.R1410Q	DO41331	UCEC	ICGC	ARPSLESLL	DEG_APCC_DBOX_1	0.2222
p.A1411S	DO222404	BTCA	ICGC	ARPSLESLL	DEG_APCC_DBOX_1	0.25
p.R1415W	DO233136	GACA	ICGC	ARPSLESLL	DEG_APCC_DBOX_1	0.8634
p.A1423E	DO229036	LICA	ICGC	ARPSLESLL	DEG_APCC_DBOX_1	0.3056
p.G1425S	DO222837	MELA	ICGC	ARPSLESLL	DEG_APCC_DBOX_1	0.25
p.A1414P	DO31729	OV	ICGC	ARPSLESLL	DEG_APCC_DBOX_1	0.6392
p.G1425V	DO229229	THCA	ICGC	ARPSLESLL	DEG_APCC_DBOX_1	0.25
p.G1425V	ACH-000871	Lung Cancer	CCLE	ARPSLESLL	DEG_APCC_DBOX_1	0.25
p.A1408V	SIDM00429	B-Lymphoblastic Leukemia	GDSC	ARPSLESLL	DEG_APCC_DBOX_1	0.1667
p.E1409K	ACH-000481	Lung Cancer	CCLE	ARPSLESLL	DEG_APCC_DBOX_1	0.1944
p.A1414V	ACH-002800	Unknown	CCLE	ARPSLESLL	DEG_APCC_DBOX_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15417	Trinucleotide repeat-containing gene 18 protein	DEG_APCC_DBOX_1	1414:1422	ARPSLESLL	APC,CDC20,FZR1	0.6014	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons