DegronMD

Uniprot ID: O15417

Source protein: Trinucleotide repeat-containing gene 18 protein

Source gene: TNRC18

Class: DEG_Kelch_Keap1_1

Location: 2308:2313

E3 ligase: KEAP1

DEGRON score: 0.8537

ASA_SCORE: 109.65

COIL: 0.9542

CONS_SCORE: 0.3816

DSS_SCORE: 0.731

HELIX: 0.0352

FCONS_SCORE: 0.9277

RIG_SCORE: 0.5605

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K2309R	ACH-001685	Lymphoma	CCLE	SKDTGE	DEG_Kelch_Keap1_1	0.6126
p.T2319M	SIDM00889	Cervical Carcinoma	GDSC	SKDTGE	DEG_Kelch_Keap1_1	0.6111
p.K2315R	SIDM00951	T-Lymphoblastic Leukemia	GDSC	SKDTGE	DEG_Kelch_Keap1_1	0.2778
p.K2315R	ACH-002222	Leukemia	CCLE	SKDTGE	DEG_Kelch_Keap1_1	0.2778
p.K2315R	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	SKDTGE	DEG_Kelch_Keap1_1	0.2778
p.K2301T	DO229234	THCA	ICGC	SKDTGE	DEG_Kelch_Keap1_1	0.25
p.R2302C	TCGA-B7-5816	STAD	TCGA	SKDTGE	DEG_Kelch_Keap1_1	0.1667
p.R2302C	DO38599	STAD	ICGC	SKDTGE	DEG_Kelch_Keap1_1	0.1667
p.G2321E	DO42673	UCEC	ICGC	SKDTGE	DEG_Kelch_Keap1_1	0.1111
p.G2321W	SIDM02034	Colorectal Carcinoma	GDSC	SKDTGE	DEG_Kelch_Keap1_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15417	Trinucleotide repeat-containing gene 18 protein	DEG_Kelch_Keap1_1	2308:2313	SKDTGE	KEAP1	0.8537	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons