DegronMD

Uniprot ID: O15417

Source protein: Trinucleotide repeat-containing gene 18 protein

Source gene: TNRC18

Class: DEG_APCC_KENBOX_2

Location: 2098:2102

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5707

ASA_SCORE: 130.62

COIL: 0.707

CONS_SCORE: 0.3446

DSS_SCORE: 0.6085

HELIX: 0.2478

FCONS_SCORE: 0.9659

RIG_SCORE: 0.6549

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2105E	TCGA-12-3651	GBM	TCGA	KKENR	DEG_APCC_KENBOX_2	0.25
p.G2105E	DO13845	GBM	ICGC	KKENR	DEG_APCC_KENBOX_2	0.25
p.R2102C	TCGA-AX-A1C9	UCEC	TCGA	KKENR	DEG_APCC_KENBOX_2	0.719
p.R2102C	DO43098	UCEC	ICGC	KKENR	DEG_APCC_KENBOX_2	0.719
p.K2098N	TCGA-D1-A17F	UCEC	TCGA	KKENR	DEG_APCC_KENBOX_2	0.5806
p.K2098N	DO43362	UCEC	ICGC	KKENR	DEG_APCC_KENBOX_2	0.5806
p.R2102H	TCGA-EO-A22R	UCEC	TCGA	KKENR	DEG_APCC_KENBOX_2	0.7133
p.R2102H	DO42713	UCEC	ICGC	KKENR	DEG_APCC_KENBOX_2	0.7133
p.K2089N	DO229275	THCA	ICGC	KKENR	DEG_APCC_KENBOX_2	0.1944
p.G2103S	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	KKENR	DEG_APCC_KENBOX_2	0.3056
p.G2103S	ACH-000611	Lymphoma	CCLE	KKENR	DEG_APCC_KENBOX_2	0.3056
p.G2103S	SU-DHL-6	haematopoietic_and_lymphoid_tissue	COSMIC	KKENR	DEG_APCC_KENBOX_2	0.3056
p.M2112I	ACH-000851	Lung Cancer	CCLE	KKENR	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	DEG_APCC_KENBOX_2	1005:1009	KKENR	APC,CDC20,FZR1	0.9715	More...
O15417	Trinucleotide repeat-containing gene 18 protein	DEG_APCC_KENBOX_2	2098:2102	KKENR	APC,CDC20,FZR1	0.5707	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons