DegronMD

Uniprot ID: Q70EL4

Source protein: Ubiquitin carboxyl-terminal hydrolase 43

Source gene: USP43

Class: DEG_APCC_KENBOX_2

Location: 1005:1009

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9715

ASA_SCORE: 129.86

COIL: 0.839

CONS_SCORE: 0.2894

DSS_SCORE: 0.5061

HELIX: 0.1216

FCONS_SCORE: 0.9901

RIG_SCORE: 0.7321

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1002A	TCGA-12-1088	GBM	TCGA	KKENR	DEG_APCC_KENBOX_2	0.25
p.V1002A	DO13701	GBM	ICGC	KKENR	DEG_APCC_KENBOX_2	0.25
p.R1004W	TCGA-DA-A3F8	SKCM	TCGA	KKENR	DEG_APCC_KENBOX_2	0.3056
p.R1004W	TCGA-QB-A6FS	SKCM	TCGA	KKENR	DEG_APCC_KENBOX_2	0.3056
p.R1004W	DO37418	SKCM	ICGC	KKENR	DEG_APCC_KENBOX_2	0.3056
p.R1004W	DO48654	SKCM	ICGC	KKENR	DEG_APCC_KENBOX_2	0.3056
p.R1004W	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	KKENR	DEG_APCC_KENBOX_2	0.3056
p.R1004W	ACH-000511	Lung Cancer	CCLE	KKENR	DEG_APCC_KENBOX_2	0.3056
p.T997I	TCGA-EE-A2MS	SKCM	TCGA	KKENR	DEG_APCC_KENBOX_2	0.5556
p.T997I	DO37567	SKCM	ICGC	KKENR	DEG_APCC_KENBOX_2	0.5556
p.R1013M	TCGA-HF-A5NB	STAD	TCGA	KKENR	DEG_APCC_KENBOX_2	0.2222
p.R1013M	DO50127	STAD	ICGC	KKENR	DEG_APCC_KENBOX_2	0.2222
p.R1009G	DO234350	ESAD	ICGC	KKENR	DEG_APCC_KENBOX_2	0.6457
p.R1000S	DO228974	LICA	ICGC	KKENR	DEG_APCC_KENBOX_2	0.1944
p.V1016A	ACH-001991	Primary	CCLE	KKENR	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	DEG_APCC_KENBOX_2	1005:1009	KKENR	APC,CDC20,FZR1	0.9715	More...
O15417	Trinucleotide repeat-containing gene 18 protein	DEG_APCC_KENBOX_2	2098:2102	KKENR	APC,CDC20,FZR1	0.5707	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons