DegronMD - Q70EL4(USP43)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1002A	TCGA-12-1088	GBM	TCGA	KKENR	DEG_APCC_KENBOX_2	1005:1009	Mutation rewiring degron network	0.25
p.V1002A	DO13701	GBM	ICGC	KKENR	DEG_APCC_KENBOX_2	1005:1009	Mutation rewiring degron network	0.25
p.A799V	TCGA-29-1778	OV	TCGA	APTTS	DEG_SPOP_SBC_1	799:803	Mutation altering degron motif	0.5825
p.A799V	DO28932	OV	ICGC	APTTS	DEG_SPOP_SBC_1	799:803	Mutation altering degron motif	0.5825
p.P800S	TCGA-A5-A0G2	UCEC	TCGA	APTTS	DEG_SPOP_SBC_1	799:803	Mutation altering degron motif	0.5641
p.P800S	DO41235	UCEC	ICGC	APTTS	DEG_SPOP_SBC_1	799:803	Mutation altering degron motif	0.5641
p.V850A	TCGA-A5-A0G2	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.2222
p.V850A	DO41235	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.2222
p.T854A	TCGA-AP-A1DV	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.1111
p.T854A	DO43186	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.1111
p.R840Q	TCGA-AX-A05Z	UCEC	TCGA	PRSTS	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.2778
p.R840Q	DO40884	UCEC	ICGC	PRSTS	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.2778
p.R1004W	TCGA-DA-A3F8	SKCM	TCGA	KKENR	DEG_APCC_KENBOX_2	1005:1009	Mutation rewiring degron network	0.3056
p.R1004W	TCGA-QB-A6FS	SKCM	TCGA	KKENR	DEG_APCC_KENBOX_2	1005:1009	Mutation rewiring degron network	0.3056
p.R1004W	DO37418	SKCM	ICGC	KKENR	DEG_APCC_KENBOX_2	1005:1009	Mutation rewiring degron network	0.3056
p.R1004W	DO48654	SKCM	ICGC	KKENR	DEG_APCC_KENBOX_2	1005:1009	Mutation rewiring degron network	0.3056
p.R1004W	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	KKENR	DEG_APCC_KENBOX_2	1005:1009	Mutation rewiring degron network	0.3056
p.R1004W	ACH-000511	Lung Cancer	CCLE	KKENR	DEG_APCC_KENBOX_2	1005:1009	Mutation rewiring degron network	0.3056
p.S851L	TCGA-EB-A3XD	SKCM	TCGA	PRSTS	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.1944
p.S851L	DO228138	PBCA	ICGC	PRSTS	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.1944
p.S851L	DO37871	SKCM	ICGC	PRSTS	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.1944
p.S803P	TCGA-EE-A29G	SKCM	TCGA	APTTS	DEG_SPOP_SBC_1	799:803	Mutation altering degron motif	0.6752
p.S803P	DO47303	SKCM	ICGC	APTTS	DEG_SPOP_SBC_1	799:803	Mutation altering degron motif	0.6752
p.T997I	TCGA-EE-A2MS	SKCM	TCGA	KKENR	DEG_APCC_KENBOX_2	1005:1009	Mutation blocking phosphorylation signal	0.5556
p.T997I	DO37567	SKCM	ICGC	KKENR	DEG_APCC_KENBOX_2	1005:1009	Mutation blocking phosphorylation signal	0.5556
p.Q921H	TCGA-G5-6233	READ	TCGA	LKENA	DEG_APCC_KENBOX_2	915:919	Mutation rewiring degron network	0.2778
p.Q921H	DO36626	READ	ICGC	LKENA	DEG_APCC_KENBOX_2	915:919	Mutation rewiring degron network	0.2778
p.R1013M	TCGA-HF-A5NB	STAD	TCGA	KKENR	DEG_APCC_KENBOX_2	1005:1009	Mutation rewiring degron network	0.2222
p.R1013M	DO50127	STAD	ICGC	KKENR	DEG_APCC_KENBOX_2	1005:1009	Mutation rewiring degron network	0.2222
p.R804L	TCGA-L9-A7SV	LUAD	TCGA	APTTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.3056
p.R804L	DO49875	LUAD	ICGC	APTTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.3056
p.M797T	DO8360	COAD	ICGC	APTTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.2778
p.M797T	SIDM00282	Colorectal Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.2778
p.M797T	CW-2	large intestine	COSMIC	APTTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.2778
p.R1009G	DO234350	ESAD	ICGC	KKENR	DEG_APCC_KENBOX_2	1005:1009	Mutation altering degron motif	0.6457
p.T854M	DO233709	GACA	ICGC	PRSTS	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.1111
p.S906L	DO233745	GACA	ICGC	LKENA	DEG_APCC_KENBOX_2	915:919	Mutation rewiring degron network	0.0833
p.S796N	DO233814	GACA	ICGC	APTTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.25
p.L836F	DO228952	LICA	ICGC	PRSTS	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.1667
p.R1000S	DO228974	LICA	ICGC	KKENR	DEG_APCC_KENBOX_2	1005:1009	Mutation rewiring degron network	0.1944
p.LV832LM	DO222363	MELA	ICGC	PRSTS	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0
p.P842L	DO222880	MELA	ICGC	PRSTS	DEG_SPOP_SBC_1	842:846	Mutation altering degron motif	0.7582
p.Q847H	DO50690	ORCA	ICGC	PRSTS	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.3056
p.G920E	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LKENA	DEG_APCC_KENBOX_2	915:919	Mutation rewiring degron network	0.3056
p.G920E	ACH-000995	Leukemia	CCLE	LKENA	DEG_APCC_KENBOX_2	915:919	Mutation rewiring degron network	0.3056
p.G920E	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LKENA	DEG_APCC_KENBOX_2	915:919	Mutation rewiring degron network	0.3056
p.V790M	SIDM01171	Glioblastoma	GDSC	APTTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.0833
p.V790M	SIDM01018	Hodgkin's Lymphoma	GDSC	APTTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.0833
p.V790M	KM-H2	haematopoietic and lymphoid tissue	COSMIC	APTTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.0833
p.V790M	T98G	central nervous system	COSMIC	APTTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.0833
p.R841I	SIDM01611	Endometrial Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.3056
p.R841I	ACH-000996	Endometrial/Uterine Cancer	CCLE	PRSTS	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.3056
p.V1016A	ACH-001991	Primary	CCLE	KKENR	DEG_APCC_KENBOX_2	1005:1009	Mutation rewiring degron network	0.1389
p.L928V	NCI-H2196	lung	COSMIC	LKENA	DEG_APCC_KENBOX_2	915:919	Mutation substituting flanking lysine	0.1944
p.G915E	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LKENA	DEG_APCC_KENBOX_2	915:919	Mutation altering degron motif	0.7199
p.M792T	CW-2	large intestine	COSMIC	APTTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP43

UniProt ID: Q70EL4

Entrez ID: 124739

Protein name: Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP43 in