DegronMD

Uniprot ID: Q70EL4

Source protein: Ubiquitin carboxyl-terminal hydrolase 43

Source gene: USP43

Class: DEG_APCC_KENBOX_2

Location: 915:919

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.943

ASA_SCORE: 96.82

COIL: 0.667

CONS_SCORE: 0.2946

DSS_SCORE: 0.6452

HELIX: 0.3158

FCONS_SCORE: 1.076

RIG_SCORE: 0.6942

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q921H	TCGA-G5-6233	READ	TCGA	LKENA	DEG_APCC_KENBOX_2	0.2778
p.Q921H	DO36626	READ	ICGC	LKENA	DEG_APCC_KENBOX_2	0.2778
p.S906L	DO233745	GACA	ICGC	LKENA	DEG_APCC_KENBOX_2	0.0833
p.G920E	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LKENA	DEG_APCC_KENBOX_2	0.3056
p.G920E	ACH-000995	Leukemia	CCLE	LKENA	DEG_APCC_KENBOX_2	0.3056
p.G920E	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LKENA	DEG_APCC_KENBOX_2	0.3056
p.L928V	NCI-H2196	lung	COSMIC	LKENA	DEG_APCC_KENBOX_2	0.1944
p.G915E	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LKENA	DEG_APCC_KENBOX_2	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07949	Proto-oncogene tyrosine-protein kinase receptor Ret	DEG_APCC_KENBOX_2	760:764	LKENA	APC,CDC20,FZR1	0.715	More...
Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	DEG_APCC_KENBOX_2	915:919	LKENA	APC,CDC20,FZR1	0.943	More...
Q9NQG7	Hermansky-Pudlak syndrome 4 protein	DEG_APCC_KENBOX_2	293:297	LKENA	APC,CDC20,FZR1	0.7258	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons