DegronMD

Uniprot ID: P07949

Source protein: Proto-oncogene tyrosine-protein kinase receptor Ret

Source gene: RET

Class: DEG_APCC_KENBOX_2

Location: 760:764

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.715

ASA_SCORE: 79.16

COIL: 0.8272

CONS_SCORE: 0.6087

DSS_SCORE: 0.2571

HELIX: 0.0194

FCONS_SCORE: 0.9472

RIG_SCORE: 0.7874

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V757M	TCGA-62-A46Y	LUAD	TCGA	LKENA	DEG_APCC_KENBOX_2	0.25
p.V757M	DO48883	LUAD	ICGC	LKENA	DEG_APCC_KENBOX_2	0.25
p.A756G	TCGA-77-8140	LUSC	TCGA	LKENA	DEG_APCC_KENBOX_2	0.2222
p.A756G	DO26834	LUSC	ICGC	LKENA	DEG_APCC_KENBOX_2	0.2222
p.P766Q	TCGA-95-7039	LUAD	TCGA	LKENA	DEG_APCC_KENBOX_2	0.2778
p.P766Q	DO23907	LUAD	ICGC	LKENA	DEG_APCC_KENBOX_2	0.2778
p.N763K	TCGA-99-8025	LUAD	TCGA	LKENA	DEG_APCC_KENBOX_2	0.6918
p.N763K	DO24255	LUAD	ICGC	LKENA	DEG_APCC_KENBOX_2	0.6918
p.A756V	TCGA-AA-A010	COAD	TCGA	LKENA	DEG_APCC_KENBOX_2	0.2222
p.E768G	TCGA-E6-A1LX	UCEC	TCGA	LKENA	DEG_APCC_KENBOX_2	0.2222
p.E768G	DO41020	UCEC	ICGC	LKENA	DEG_APCC_KENBOX_2	0.2222
p.A756D	TCGA-IB-7651	PAAD	TCGA	LKENA	DEG_APCC_KENBOX_2	0.2222
p.A756D	DO46657	PAAD	ICGC	LKENA	DEG_APCC_KENBOX_2	0.2222
p.M759I	TCGA-MA-AA3X	CESC	TCGA	LKENA	DEG_APCC_KENBOX_2	0.3056
p.M759I	DO219720	CESC	ICGC	LKENA	DEG_APCC_KENBOX_2	0.3056
p.A764T	DO230342	COCA	ICGC	LKENA	DEG_APCC_KENBOX_2	0.6028
p.A764T	DO52496	COCA	ICGC	LKENA	DEG_APCC_KENBOX_2	0.6028
p.A764T	DO42673	UCEC	ICGC	LKENA	DEG_APCC_KENBOX_2	0.6028
p.L772P	DO233293	NACA	ICGC	LKENA	DEG_APCC_KENBOX_2	0.1111
p.T754M	DO228138	PBCA	ICGC	LKENA	DEG_APCC_KENBOX_2	0.6111
p.A750V	DO229264	THCA	ICGC	LKENA	DEG_APCC_KENBOX_2	0.0556
p.S765F	SIDM00336	Melanoma	GDSC	LKENA	DEG_APCC_KENBOX_2	0.3056
p.S765F	ACH-000881	Skin Cancer	CCLE	LKENA	DEG_APCC_KENBOX_2	0.3056
p.S765F	MEL-JUSO	skin	COSMIC	LKENA	DEG_APCC_KENBOX_2	0.3056
p.A750T	SIDM00151	Ovarian Carcinoma	GDSC	LKENA	DEG_APCC_KENBOX_2	0.0556
p.A750T	ACH-000966	Ovarian Cancer	CCLE	LKENA	DEG_APCC_KENBOX_2	0.0556
p.A750T	IGROV-1	ovary	COSMIC	LKENA	DEG_APCC_KENBOX_2	0.0556

Drug responses associated with RET mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00729	LUAD\|lung_NSCLC_adenocarcinoma	p.A498V (No)	GDSC	Cabozantinib	17.7563
SIDM00729	LUAD\|lung_NSCLC_adenocarcinoma	p.A498V (No)	GDSC	Motesanib	18.0767
SIDM01024	ESCA\|oesophagus	p.A217V (No)	GDSC	Cabozantinib	76.1936
SIDM01024	ESCA\|oesophagus	p.A217V (No)	GDSC	Motesanib	3.5405
SIDM00951	LAML\|acute_myeloid_leukaemia	p.C656F (No)	GDSC	Sunitinib	1.7779
SIDM00951	LAML\|acute_myeloid_leukaemia	p.C656F (No)	GDSC	Cabozantinib	2.3117
SIDM00951	LAML\|acute_myeloid_leukaemia	p.C656F (No)	GDSC	Motesanib	4.4666
SIDM00607	LGG\|glioma	p.V637M (No)	GDSC	Sunitinib	88.7242
SIDM00607	LGG\|glioma	p.V637M (No)	GDSC	Cabozantinib	16.91
SIDM00607	LGG\|glioma	p.V637M (No)	GDSC	Motesanib	30.5258
SIDM00607	LGG\|glioma	p.V637M (No)	GDSC	XMD11-85h	33.3957
SIDM00151	OV\|ovary	p.A750T (Yes)	GDSC	Motesanib	51.1276
SIDM00782	COREAD\|large_intestine	p.R189H (No)	GDSC	Cabozantinib	14.3805
SIDM00782	COREAD\|large_intestine	p.R189H (No)	GDSC	Motesanib	30.941
SIDM00782	COREAD\|large_intestine	p.R189H (No)	GDSC	XMD11-85h	153.9933
SIDM00782	COREAD\|large_intestine	p.S561I (No)	GDSC	Cabozantinib	14.3805
SIDM00782	COREAD\|large_intestine	p.S561I (No)	GDSC	Motesanib	30.941
SIDM00782	COREAD\|large_intestine	p.S561I (No)	GDSC	XMD11-85h	153.9933
SIDM00683	PRAD\|prostate	p.R77H (No)	GDSC	Sunitinib	69.7013
SIDM00683	PRAD\|prostate	p.R77H (No)	GDSC	Cabozantinib	9.9083
SIDM00683	PRAD\|prostate	p.R77H (No)	GDSC	Motesanib	30.6555
SIDM00683	PRAD\|prostate	p.R77H (No)	GDSC	XMD11-85h	27.4782
SIDM00683	PRAD\|prostate	p.Y791F (No)	GDSC	Sunitinib	69.7013
SIDM00683	PRAD\|prostate	p.Y791F (No)	GDSC	Cabozantinib	9.9083
SIDM00683	PRAD\|prostate	p.Y791F (No)	GDSC	Motesanib	30.6555
SIDM00683	PRAD\|prostate	p.Y791F (No)	GDSC	XMD11-85h	27.4782
SIDM00683	PRAD\|prostate	p.I858T (No)	GDSC	Sunitinib	69.7013
SIDM00683	PRAD\|prostate	p.I858T (No)	GDSC	Cabozantinib	9.9083
SIDM00683	PRAD\|prostate	p.I858T (No)	GDSC	Motesanib	30.6555
SIDM00683	PRAD\|prostate	p.I858T (No)	GDSC	XMD11-85h	27.4782
SIDM00849	KIRC\|kidney	p.T492N (No)	GDSC	Sunitinib	11.6783
SIDM00849	KIRC\|kidney	p.T492N (No)	GDSC	Cabozantinib	9.1978
SIDM00849	KIRC\|kidney	p.T492N (No)	GDSC	Motesanib	10.4
SIDM00849	KIRC\|kidney	p.T492N (No)	GDSC	XMD11-85h	36.8239
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.R77L (No)	GDSC	Sunitinib	20.9013
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.R77L (No)	GDSC	Cabozantinib	23.515
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.R77L (No)	GDSC	Motesanib	3.309
SIDM00461	LAML\|acute_myeloid_leukaemia	p.N1084S (No)	GDSC	Sunitinib	0.262
SIDM00461	LAML\|acute_myeloid_leukaemia	p.N1084S (No)	GDSC	Cabozantinib	0.4321
SIDM00461	LAML\|acute_myeloid_leukaemia	p.N1084S (No)	GDSC	Motesanib	15.6128
SIDM00461	LAML\|acute_myeloid_leukaemia	p.N1084S (No)	GDSC	XMD11-85h	78.469
SIDM00461	LAML\|acute_myeloid_leukaemia	p.P1091A (No)	GDSC	Sunitinib	0.262
SIDM00461	LAML\|acute_myeloid_leukaemia	p.P1091A (No)	GDSC	Cabozantinib	0.4321
SIDM00461	LAML\|acute_myeloid_leukaemia	p.P1091A (No)	GDSC	Motesanib	15.6128
SIDM00461	LAML\|acute_myeloid_leukaemia	p.P1091A (No)	GDSC	XMD11-85h	78.469
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L1101V (No)	GDSC	Sunitinib	0.262
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L1101V (No)	GDSC	Cabozantinib	0.4321
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L1101V (No)	GDSC	Motesanib	15.6128
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L1101V (No)	GDSC	XMD11-85h	78.469
SIDM00519	MESO\|mesothelioma	p.S173P (No)	GDSC	Cabozantinib	8.1118
SIDM00519	MESO\|mesothelioma	p.S173P (No)	GDSC	Motesanib	21.4294
SIDM00519	MESO\|mesothelioma	p.S173P (No)	GDSC	XMD11-85h	193.5587
SIDM01107	SKCM\|melanoma	p.Y791F (No)	GDSC	Sunitinib	22.4386
SIDM01107	SKCM\|melanoma	p.Y791F (No)	GDSC	Cabozantinib	170.0174
SIDM01107	SKCM\|melanoma	p.Y791F (No)	GDSC	Motesanib	21.6739
SIDM01107	SKCM\|melanoma	p.Y791F (No)	GDSC	XMD11-85h	280.243
SIDM01007	ALL\|lymphoblastic_leukemia	p.N879S (No)	GDSC	Sunitinib	2.0565
SIDM01007	ALL\|lymphoblastic_leukemia	p.N879S (No)	GDSC	Cabozantinib	1.7755
SIDM01007	ALL\|lymphoblastic_leukemia	p.N879S (No)	GDSC	Motesanib	12.841
SIDM00091	OV\|ovary	p.R79Q (No)	GDSC	Cabozantinib	29.573
SIDM00091	OV\|ovary	p.R79Q (No)	GDSC	Motesanib	4.5718
SIDM00184	SKCM\|melanoma	p.S401C (No)	GDSC	Sunitinib	104.5319
SIDM00184	SKCM\|melanoma	p.S401C (No)	GDSC	Cabozantinib	27.7034
SIDM00184	SKCM\|melanoma	p.S401C (No)	GDSC	Motesanib	7.5897
SIDM00184	SKCM\|melanoma	p.S401C (No)	GDSC	XMD11-85h	92.7316
SIDM00945	COREAD\|large_intestine	p.R77H (No)	GDSC	Motesanib	53.4553
SIDM00945	COREAD\|large_intestine	p.R77H (No)	GDSC	XMD11-85h	204.9445
SIDM00945	COREAD\|large_intestine	p.V438I (No)	GDSC	Motesanib	53.4553
SIDM00945	COREAD\|large_intestine	p.V438I (No)	GDSC	XMD11-85h	204.9445
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.A680T (No)	GDSC	Sunitinib	9.3767
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.A680T (No)	GDSC	Cabozantinib	6.525
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.A680T (No)	GDSC	Motesanib	26.0901
SIDM00484	THCA\|thyroid	p.C634W (No)	GDSC	Cabozantinib	60.0418
SIDM00484	THCA\|thyroid	p.C634W (No)	GDSC	Motesanib	2.6458
SIDM00484	THCA\|thyroid	p.C634W (No)	GDSC	XMD11-85h	333.7953
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.S853T (No)	GDSC	Motesanib	16.8754
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.S853T (No)	GDSC	XMD11-85h	328.3027
SIDM01237	LIHC\|liver	p.D567N (No)	GDSC	Cabozantinib	82.098
SIDM01237	LIHC\|liver	p.D567N (No)	GDSC	Motesanib	16.4376
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.S201R (No)	GDSC	Sunitinib	5.8574
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.S201R (No)	GDSC	Cabozantinib	4.4868
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.S201R (No)	GDSC	Motesanib	21.9259
SIDM00751	LUAD\|lung_NSCLC_adenocarcinoma	p.L318V (No)	GDSC	Cabozantinib	40.1612
SIDM00751	LUAD\|lung_NSCLC_adenocarcinoma	p.L318V (No)	GDSC	Motesanib	3.8845
SIDM00751	LUAD\|lung_NSCLC_adenocarcinoma	p.L318V (No)	GDSC	XMD11-85h	41.4783
SIDM00792	SCLC\|lung_small_cell_carcinoma	p.P973T (No)	GDSC	Cabozantinib	7.7925
SIDM00792	SCLC\|lung_small_cell_carcinoma	p.P973T (No)	GDSC	Motesanib	3.2422
SIDM00792	SCLC\|lung_small_cell_carcinoma	p.P973T (No)	GDSC	XMD11-85h	133.7068
SIDM01045	UCEC\|endometrium	p.P695A (No)	GDSC	Cabozantinib	11.3765
SIDM01045	UCEC\|endometrium	p.P695A (No)	GDSC	Motesanib	50.6745
SIDM01045	UCEC\|endometrium	p.P695A (No)	GDSC	XMD11-85h	219.324
SIDM00946	ALL\|T_cell_leukemia	p.S1002N (No)	GDSC	Sunitinib	3.1015
SIDM00946	ALL\|T_cell_leukemia	p.S1002N (No)	GDSC	Cabozantinib	8.6717
SIDM00946	ALL\|T_cell_leukemia	p.S1002N (No)	GDSC	Motesanib	15.3786
SIDM00946	ALL\|T_cell_leukemia	p.S1002N (No)	GDSC	XMD11-85h	10.4455
SIDM00946	ALL\|T_cell_leukemia	p.N1084S (No)	GDSC	Sunitinib	3.1015
SIDM00946	ALL\|T_cell_leukemia	p.N1084S (No)	GDSC	Cabozantinib	8.6717
SIDM00946	ALL\|T_cell_leukemia	p.N1084S (No)	GDSC	Motesanib	15.3786
SIDM00946	ALL\|T_cell_leukemia	p.N1084S (No)	GDSC	XMD11-85h	10.4455
SIDM01157	UNCLASSIFIED\|urogenital_system_other	p.R330W (No)	GDSC	Sunitinib	4.978
SIDM01157	UNCLASSIFIED\|urogenital_system_other	p.R330W (No)	GDSC	Cabozantinib	2.1053
SIDM01157	UNCLASSIFIED\|urogenital_system_other	p.R330W (No)	GDSC	Motesanib	8.8402
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G387V (No)	GDSC	Cabozantinib	13.5361
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G387V (No)	GDSC	Motesanib	8.7254
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G387V (No)	GDSC	XMD11-85h	24.8078
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S688Y (No)	GDSC	Cabozantinib	13.5361
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S688Y (No)	GDSC	Motesanib	8.7254
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S688Y (No)	GDSC	XMD11-85h	24.8078
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.D1017E (No)	GDSC	Cabozantinib	13.5361
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.D1017E (No)	GDSC	Motesanib	8.7254
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.D1017E (No)	GDSC	XMD11-85h	24.8078
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D1004Y (No)	GDSC	Cabozantinib	58.3136
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D1004Y (No)	GDSC	Motesanib	11.1263
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.D1004Y (No)	GDSC	XMD11-85h	85.4102
SIDM00217	COREAD\|large_intestine	p.L318M (No)	GDSC	Cabozantinib	12.0756
SIDM00216	COREAD\|large_intestine	p.T1038A (No)	GDSC	Cabozantinib	6.0987
SIDM01096	COREAD\|large_intestine	p.E991K (No)	GDSC	Cabozantinib	46.7809
SIDM01096	COREAD\|large_intestine	p.E991K (No)	GDSC	Motesanib	11.7321
SIDM01096	COREAD\|large_intestine	p.E991K (No)	GDSC	XMD11-85h	75.0552
SIDM00282	COREAD\|large_intestine	p.A45T (No)	GDSC	Sunitinib	189.499
SIDM00282	COREAD\|large_intestine	p.A45T (No)	GDSC	Cabozantinib	55.7164
SIDM00282	COREAD\|large_intestine	p.A45T (No)	GDSC	Motesanib	57.5889
SIDM00282	COREAD\|large_intestine	p.A45T (No)	GDSC	XMD11-85h	133.3314
SIDM00574	LGG\|glioma	p.D631N (No)	GDSC	Sunitinib	13.6015
SIDM00574	LGG\|glioma	p.D631N (No)	GDSC	Cabozantinib	75.8238
SIDM00574	LGG\|glioma	p.D631N (No)	GDSC	Motesanib	32.9845
SIDM00574	LGG\|glioma	p.D631N (No)	GDSC	XMD11-85h	60.6134
SIDM00574	LGG\|glioma	p.P1074L (No)	GDSC	Sunitinib	13.6015
SIDM00574	LGG\|glioma	p.P1074L (No)	GDSC	Cabozantinib	75.8238
SIDM00574	LGG\|glioma	p.P1074L (No)	GDSC	Motesanib	32.9845
SIDM00574	LGG\|glioma	p.P1074L (No)	GDSC	XMD11-85h	60.6134
SIDM01071	SCLC\|lung_small_cell_carcinoma	p.N151S (No)	GDSC	Sunitinib	35.5508
SIDM01071	SCLC\|lung_small_cell_carcinoma	p.N151S (No)	GDSC	Cabozantinib	36.5642
SIDM00660	COREAD\|large_intestine	p.L1048fs*11 (No)	GDSC	Sunitinib	10.3118
SIDM00660	COREAD\|large_intestine	p.L1048fs*11 (No)	GDSC	Cabozantinib	13.9018
SIDM00660	COREAD\|large_intestine	p.L1048fs*11 (No)	GDSC	Motesanib	31.3099
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N1084S (No)	GDSC	Sunitinib	4.5704
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N1084S (No)	GDSC	Cabozantinib	3.3609
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N1084S (No)	GDSC	Motesanib	14.8551
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N1084S (No)	GDSC	XMD11-85h	7.9834
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.P1091A (No)	GDSC	Sunitinib	4.5704
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.P1091A (No)	GDSC	Cabozantinib	3.3609
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.P1091A (No)	GDSC	Motesanib	14.8551
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.P1091A (No)	GDSC	XMD11-85h	7.9834
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L1101V (No)	GDSC	Sunitinib	4.5704
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L1101V (No)	GDSC	Cabozantinib	3.3609
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L1101V (No)	GDSC	Motesanib	14.8551
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L1101V (No)	GDSC	XMD11-85h	7.9834
SIDM00116	LUAD\|lung_NSCLC_adenocarcinoma	p.A281V (No)	GDSC	Cabozantinib	43.6646
SIDM00116	LUAD\|lung_NSCLC_adenocarcinoma	p.A281V (No)	GDSC	Motesanib	28.8326
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.E805* (No)	GDSC	Sunitinib	135.0418
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.E805* (No)	GDSC	Cabozantinib	80.591
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.E805* (No)	GDSC	Motesanib	42.2863
SIDM00375	HNSC\|head_and_neck	p.T278N (No)	GDSC	Cabozantinib	51.7016
SIDM00375	HNSC\|head_and_neck	p.T278N (No)	GDSC	Motesanib	27.3106
SIDM01205	DLBC\|B_cell_lymphoma	p.Y791F (No)	GDSC	Sunitinib	67.6818
SIDM01205	DLBC\|B_cell_lymphoma	p.Y791F (No)	GDSC	Cabozantinib	8.7434
SIDM01205	DLBC\|B_cell_lymphoma	p.Y791F (No)	GDSC	Motesanib	9.8384
SIDM01205	DLBC\|B_cell_lymphoma	p.Y791F (No)	GDSC	XMD11-85h	31.8841
SIDM00789	COREAD\|large_intestine	p.M980T (No)	GDSC	Cabozantinib	14.2209
SIDM00789	COREAD\|large_intestine	p.M980T (No)	GDSC	Motesanib	12.7822
SIDM00789	COREAD\|large_intestine	p.M980T (No)	GDSC	XMD11-85h	138.9371
SIDM00336	SKCM\|melanoma	p.S765F (Yes)	GDSC	Cabozantinib	9.192
SIDM00336	SKCM\|melanoma	p.S765F (Yes)	GDSC	Motesanib	4.5686
SIDM01033	BLCA\|bladder	p.R114H (No)	GDSC	Cabozantinib	53.686
SIDM01033	BLCA\|bladder	p.R114H (No)	GDSC	Motesanib	12.5075
SIDM01033	BLCA\|bladder	p.R114H (No)	GDSC	XMD11-85h	9.0863
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.Y791F (No)	GDSC	Sunitinib	9.6747
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.Y791F (No)	GDSC	Cabozantinib	3.557
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.Y791F (No)	GDSC	Motesanib	14.2029
SIDM01087	SKCM\|melanoma	p.S401C (No)	GDSC	Cabozantinib	5.6829
SIDM01087	SKCM\|melanoma	p.S401C (No)	GDSC	Motesanib	8.6977
SIDM01087	SKCM\|melanoma	p.S401C (No)	GDSC	XMD11-85h	48.4976
SIDM00545	SKCM\|melanoma	p.Y791F (No)	GDSC	Cabozantinib	107.4008
SIDM00545	SKCM\|melanoma	p.Y791F (No)	GDSC	Motesanib	13.0462
SIDM00994	ALL\|T_cell_leukemia	p.Y791F (No)	GDSC	Sunitinib	1.1173
SIDM00994	ALL\|T_cell_leukemia	p.Y791F (No)	GDSC	Cabozantinib	0.3851
SIDM00994	ALL\|T_cell_leukemia	p.Y791F (No)	GDSC	Motesanib	11.0276
SIDM00994	ALL\|T_cell_leukemia	p.Y791F (No)	GDSC	XMD11-85h	9.7208
SIDM00120	PRAD\|prostate	p.L746M (No)	GDSC	Cabozantinib	63.4851
SIDM00120	PRAD\|prostate	p.L746M (No)	GDSC	Motesanib	0.5405
SIDM00120	PRAD\|prostate	p.V804M (No)	GDSC	Cabozantinib	63.4851
SIDM00120	PRAD\|prostate	p.V804M (No)	GDSC	Motesanib	0.5405
SIDM00241	BRCA\|breast	p.G383D (No)	GDSC	Sunitinib	7.1072
SIDM00241	BRCA\|breast	p.G383D (No)	GDSC	Cabozantinib	9.3916
SIDM00241	BRCA\|breast	p.G383D (No)	GDSC	Motesanib	12.7086
SIDM00241	BRCA\|breast	p.G383D (No)	GDSC	XMD11-85h	55.7544
SIDM00570	STAD\|stomach	p.T152P (No)	GDSC	Cabozantinib	4.8518
SIDM00570	STAD\|stomach	p.T152P (No)	GDSC	Motesanib	10.448
SIDM00570	STAD\|stomach	p.T152P (No)	GDSC	XMD11-85h	18.6178
SIDM00570	STAD\|stomach	p.T278N (No)	GDSC	Cabozantinib	4.8518
SIDM00570	STAD\|stomach	p.T278N (No)	GDSC	Motesanib	10.448
SIDM00570	STAD\|stomach	p.T278N (No)	GDSC	XMD11-85h	18.6178
SIDM00652	SCLC\|lung_small_cell_carcinoma	p.G828R (No)	GDSC	Motesanib	18.3463
SIDM00225	SKCM\|melanoma	p.S837F (No)	GDSC	Sunitinib	4.5073
SIDM00225	SKCM\|melanoma	p.S837F (No)	GDSC	Cabozantinib	23.0587
SIDM00225	SKCM\|melanoma	p.S837F (No)	GDSC	Motesanib	27.8266
SIDM00225	SKCM\|melanoma	p.S837F (No)	GDSC	XMD11-85h	55.5189
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1109T (No)	GDSC	Cabozantinib	68.3794
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1109T (No)	GDSC	Motesanib	25.0231
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1109T (No)	GDSC	XMD11-85h	67.6917
SIDM00296	SCLC\|lung_small_cell_carcinoma	p.A664D (No)	GDSC	Sunitinib	35.0209
SIDM00296	SCLC\|lung_small_cell_carcinoma	p.A664D (No)	GDSC	Cabozantinib	21.8214
SIDM00296	SCLC\|lung_small_cell_carcinoma	p.A664D (No)	GDSC	Motesanib	17.8326
SIDM00364	ALL\|lymphoblastic_leukemia	p.T278N (No)	GDSC	Sunitinib	15.6838
SIDM00364	ALL\|lymphoblastic_leukemia	p.T278N (No)	GDSC	Cabozantinib	2.2748
SIDM00364	ALL\|lymphoblastic_leukemia	p.T278N (No)	GDSC	Motesanib	14.1657
SIDM00374	DLBC\|B_cell_lymphoma	p.T278N (No)	GDSC	Sunitinib	11.0351
SIDM00374	DLBC\|B_cell_lymphoma	p.T278N (No)	GDSC	Cabozantinib	9.9816
SIDM00374	DLBC\|B_cell_lymphoma	p.T278N (No)	GDSC	Motesanib	27.4647
SIDM00374	DLBC\|B_cell_lymphoma	p.T278N (No)	GDSC	XMD11-85h	20.6871
SIDM00837	COREAD\|large_intestine	p.R360W (No)	GDSC	Cabozantinib	10.026
SIDM00837	COREAD\|large_intestine	p.R360W (No)	GDSC	Motesanib	10.5828
SIDM00837	COREAD\|large_intestine	p.R360W (No)	GDSC	XMD11-85h	15.5664
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.Y791N (No)	GDSC	Sunitinib	67.5213
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.Y791N (No)	GDSC	Cabozantinib	41.8362
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.Y791N (No)	GDSC	Motesanib	15.5156
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.A1105V (No)	GDSC	Sunitinib	67.5213
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.A1105V (No)	GDSC	Cabozantinib	41.8362
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.A1105V (No)	GDSC	Motesanib	15.5156
SIDM01062	BRCA\|breast	p.D567N (No)	GDSC	Cabozantinib	58.1103
SIDM01062	BRCA\|breast	p.D567N (No)	GDSC	Motesanib	32.9998
SIDM00238	OV\|ovary	p.T278N (No)	GDSC	Cabozantinib	99.6708
SIDM00238	OV\|ovary	p.T278N (No)	GDSC	Motesanib	11.224
SIDM00238	OV\|ovary	p.T278N (No)	GDSC	XMD11-85h	91.4281
SIDM00238	OV\|ovary	p.A641T (No)	GDSC	Cabozantinib	99.6708
SIDM00238	OV\|ovary	p.A641T (No)	GDSC	Motesanib	11.224
SIDM00238	OV\|ovary	p.A641T (No)	GDSC	XMD11-85h	91.4281
SIDM00693	BLCA\|bladder	p.F1112Y (No)	GDSC	Cabozantinib	32.8868
SIDM00693	BLCA\|bladder	p.F1112Y (No)	GDSC	Motesanib	6.5109
SIDM00193	COREAD\|large_intestine	p.T278N (No)	GDSC	Cabozantinib	133.9123
SIDM00193	COREAD\|large_intestine	p.T278N (No)	GDSC	Motesanib	50.1977
SIDM00193	COREAD\|large_intestine	p.T278N (No)	GDSC	XMD11-85h	111.2169
SIDM00086	KIRC\|kidney	p.I944M (No)	GDSC	Sunitinib	6.1015
SIDM00086	KIRC\|kidney	p.I944M (No)	GDSC	Cabozantinib	6.1357
SIDM00086	KIRC\|kidney	p.I944M (No)	GDSC	Motesanib	19.4607
SIDM00086	KIRC\|kidney	p.I944M (No)	GDSC	XMD11-85h	227.5218

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07949	Proto-oncogene tyrosine-protein kinase receptor Ret	DEG_APCC_KENBOX_2	760:764	LKENA	APC,CDC20,FZR1	0.715	More...
Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	DEG_APCC_KENBOX_2	915:919	LKENA	APC,CDC20,FZR1	0.943	More...
Q9NQG7	Hermansky-Pudlak syndrome 4 protein	DEG_APCC_KENBOX_2	293:297	LKENA	APC,CDC20,FZR1	0.7258	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKENA

Degron related mutations and impact score

Drug responses associated with RET mutations

All proteins holding degron of LKENA