DegronMD

Uniprot ID: Q9NQG7

Source protein: Hermansky-Pudlak syndrome 4 protein

Source gene: HPS4

Class: DEG_APCC_KENBOX_2

Location: 293:297

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7258

ASA_SCORE: 97.02

COIL: 0.7768

CONS_SCORE: 0.3918

DSS_SCORE: 0.6792

HELIX: 0.16

FCONS_SCORE: 0.9831

RIG_SCORE: 0.6201

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W306L	TCGA-22-5489	LUSC	TCGA	LKENA	DEG_APCC_KENBOX_2	0.0833
p.V301A	TCGA-AP-A0LM	UCEC	TCGA	LKENA	DEG_APCC_KENBOX_2	0.2222
p.A292S	TCGA-BH-A0BJ	BRCA	TCGA	LKENA	DEG_APCC_KENBOX_2	0.3056
p.A305T	TCGA-EY-A1GU	UCEC	TCGA	LKENA	DEG_APCC_KENBOX_2	0.1111
p.A287S	DO1737	BRCA	ICGC	LKENA	DEG_APCC_KENBOX_2	0.1667
p.P306H	DO229027	LICA	ICGC	LKENA	DEG_APCC_KENBOX_2	0.0833
p.D305H	DO230522	LUSC	ICGC	LKENA	DEG_APCC_KENBOX_2	0.1111
p.W301L	DO26480	LUSC	ICGC	LKENA	DEG_APCC_KENBOX_2	0.2222
p.P306L	DO37406	SKCM	ICGC	LKENA	DEG_APCC_KENBOX_2	0.0833
p.V296A	DO43306	UCEC	ICGC	LKENA	DEG_APCC_KENBOX_2	0.6936
p.D305Y	DO41235	UCEC	ICGC	LKENA	DEG_APCC_KENBOX_2	0.1111
p.A300T	DO41518	UCEC	ICGC	LKENA	DEG_APCC_KENBOX_2	0.25
p.H283Y	SIDM00945	Colorectal Carcinoma	GDSC	LKENA	DEG_APCC_KENBOX_2	0.0556
p.H283Y	ACH-000895	Colon/Colorectal Cancer	CCLE	LKENA	DEG_APCC_KENBOX_2	0.0556
p.H283Y	CL-34	large_intestine	COSMIC	LKENA	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07949	Proto-oncogene tyrosine-protein kinase receptor Ret	DEG_APCC_KENBOX_2	760:764	LKENA	APC,CDC20,FZR1	0.715	More...
Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	DEG_APCC_KENBOX_2	915:919	LKENA	APC,CDC20,FZR1	0.943	More...
Q9NQG7	Hermansky-Pudlak syndrome 4 protein	DEG_APCC_KENBOX_2	293:297	LKENA	APC,CDC20,FZR1	0.7258	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons