DegronMD - Q9NQG7(HPS4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W306L	TCGA-22-5489	LUSC	TCGA	LKENA	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.0833
p.V301A	TCGA-AP-A0LM	UCEC	TCGA	LKENA	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.2222
p.A292S	TCGA-BH-A0BJ	BRCA	TCGA	LKENA	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.3056
p.A305T	TCGA-EY-A1GU	UCEC	TCGA	LKENA	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.1111
p.A287S	DO1737	BRCA	ICGC	LKENA	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.1667
p.S6Y	DO222762	COCA	ICGC	ATSTS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.712
p.S6Y	DO229035	LICA	ICGC	ATSTS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.712
p.S6Y	DO229037	LICA	ICGC	ATSTS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.712
p.A8D	DO228976	LICA	ICGC	ATSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.2778
p.P306H	DO229027	LICA	ICGC	LKENA	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.0833
p.D305H	DO230522	LUSC	ICGC	LKENA	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.1111
p.W301L	DO26480	LUSC	ICGC	LKENA	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.2222
p.P306L	DO37406	SKCM	ICGC	LKENA	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.0833
p.V296A	DO43306	UCEC	ICGC	LKENA	DEG_APCC_KENBOX_2	293:297	Mutation altering degron motif	0.6936
p.D305Y	DO41235	UCEC	ICGC	LKENA	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.1111
p.A300T	DO41518	UCEC	ICGC	LKENA	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.25
p.H283Y	SIDM00945	Colorectal Carcinoma	GDSC	LKENA	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.0556
p.H283Y	ACH-000895	Colon/Colorectal Cancer	CCLE	LKENA	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.0556
p.H283Y	CL-34	large intestine	COSMIC	LKENA	DEG_APCC_KENBOX_2	293:297	Mutation rewiring degron network	0.0556
p.W15R	SIDM00683	Prostate Carcinoma	GDSC	ATSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0833
p.W15R	LNCaP-Clone-FGC	prostate	COSMIC	ATSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0833
p.W10R	LNCaP-Clone-FGC	prostate	COSMIC	ATSTS	DEG_SPOP_SBC_1	2:6	Mutation substituting flanking lysine	0.3333

Kaplan plot for HPS4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HPS4

UniProt ID: Q9NQG7

Entrez ID: 89781

Protein name: Hermansky-Pudlak syndrome 4 protein (Light-ear protein homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HPS4 in