DegronMD

Uniprot ID: O15417

Source protein: Trinucleotide repeat-containing gene 18 protein

Source gene: TNRC18

Class: DEG_SCF_FBW7_1

Location: 1039:1046

E3 ligase: FBXW7

DEGRON score: 0.9643

ASA_SCORE: 88.5375

COIL: 0.9735

CONS_SCORE: 0.4138

DSS_SCORE: 0.8003

HELIX: 0.0101

FCONS_SCORE: 1.0106

RIG_SCORE: 0.5113

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1043L	TCGA-A6-2686	COAD	TCGA	PPPTPGIT	DEG_SCF_FBW7_1	0.7582
p.P1043L	DO7828	COAD	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	0.7582
p.E1053D	TCGA-AJ-A5DW	UCEC	TCGA	PPPTPGIT	DEG_SCF_FBW7_1	0.1389
p.E1053D	DO50075	UCEC	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	0.1389
p.A1051D	TCGA-B5-A1MR	UCEC	TCGA	PPPTPGIT	DEG_SCF_FBW7_1	0.1944
p.A1051D	DO41758	UCEC	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	0.1944
p.P1040L	TCGA-BG-A0MQ	UCEC	TCGA	PPPTPGIT	DEG_SCF_FBW7_1	0.6471
p.P1040L	DO41127	UCEC	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	0.6471
p.P1043S	TCGA-EE-A2GC	SKCM	TCGA	PPPTPGIT	DEG_SCF_FBW7_1	0.6752
p.P1043S	DO37839	SKCM	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	0.6752
p.P1040S	DO230937	LUSC	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	0.5641
p.P1040S	DO224619	LUSC	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	0.5641
p.P1039S	DO229479	SKCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	0.6752
p.S1029P	DO229148	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	0.0556
p.T1032P	DO229180	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	0.5833
p.T1032P	DO229191	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	0.5833
p.T1032P	DO229095	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	0.5833
p.S1033R	DO229181	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	0.6111
p.S1033R	DO229085	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	0.6111
p.H1030P	DO229191	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	0.0833
p.H1030P	DO229199	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	0.0833
p.H1030P	DO229085	THCA	ICGC	PPPTPGIT	DEG_SCF_FBW7_1	0.0833
p.E1053K	SIDM01611	Endometrial Carcinoma	GDSC	PPPTPGIT	DEG_SCF_FBW7_1	0.1389
p.E1053K	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPPTPGIT	DEG_SCF_FBW7_1	0.1389
p.E1050K	ACH-001414	Bladder Cancer	CCLE	PPPTPGIT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15417	Trinucleotide repeat-containing gene 18 protein	DEG_SCF_FBW7_1	1039:1046	PPPTPGIT	FBXW7	0.9643	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons