DegronMD

Uniprot ID: Q96T58

Source protein: Msx2-interacting protein

Source gene: SPEN

Class: LIG_APCC_ABBA_1

Location: 3472:3477

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.995

ASA_SCORE: 101.4333

COIL: 0.9388

CONS_SCORE: 0.3141

DSS_SCORE: 0.7357

HELIX: 0.0282

FCONS_SCORE: 1.0292

RIG_SCORE: 0.6838

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3476I	TCGA-D1-A17B	UCEC	TCGA	VLPHTE	LIG_APCC_ABBA_1	0.5966
p.T3476I	DO43017	UCEC	ICGC	VLPHTE	LIG_APCC_ABBA_1	0.5966
p.G3464A	DO230990	LUSC	ICGC	VLPHTE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96T58	Msx2-interacting protein	LIG_APCC_ABBA_1	3472:3477	VLPHTE	APC,CDC20,FZR1	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons