DegronMD

Uniprot ID: Q96T58

Source protein: Msx2-interacting protein

Source gene: SPEN

Class: DEG_SCF_SKP2-CKS1_1

Location: 2417:2424

E3 ligase: SKP2,CSK1

DEGRON score: 0.9334

ASA_SCORE: 121.575

COIL: 0.94

CONS_SCORE: 0.3339

DSS_SCORE: 0.757

HELIX: 0.0365

FCONS_SCORE: 0.9168

RIG_SCORE: 0.6087

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2411L	TCGA-AJ-A3EL	UCEC	TCGA	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.6111
p.S2411L	TCGA-EO-A22R	UCEC	TCGA	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.6111
p.S2411L	TCGA-FR-A726	SKCM	TCGA	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.6111
p.S2411L	DO48665	SKCM	ICGC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.6111
p.S2411L	DO41542	UCEC	ICGC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.6111
p.S2411L	DO42713	UCEC	ICGC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.6111
p.S2426Y	TCGA-EO-A3KX	UCEC	TCGA	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.2778
p.S2426Y	DO219774	UCEC	ICGC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.2778
p.S2426T	DO223141	ESCA	ICGC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.2778
p.S2426F	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.2778
p.P2428S	TCGA-CV-7568	HNSC	TCGA	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.2222
p.P2428S	DO14160	HNSC	ICGC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.2222
p.P2428T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.2222
p.P2428T	ACH-002256	Leukemia	CCLE	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.2222
p.P2428T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.2222
p.P2434L	SIDM01041	Esophageal Carcinoma	GDSC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.0556
p.P2434L	ACH-001500	Esophageal Cancer	CCLE	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.0556
p.P2434L	FLO-1	oesophagus	COSMIC	VEERTPTK	DEG_SCF_SKP2-CKS1_1	0.0556

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96T58	Msx2-interacting protein	DEG_SCF_SKP2-CKS1_1	2417:2424	VEERTPTK	SKP2,CSK1	0.9334	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons