DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SSETSHSVPEA
Uniprot ID:
Q96T58
Source protein:
Msx2-interacting protein
Source gene:
SPEN
Class:
DEG_COP1_1
Location:
2305:2315
E3 ligase:
COP1
DEGRON score:
0.6961
ASA_SCORE:
96.6364
COIL:
0.9462
CONS_SCORE:
0.3406
DSS_SCORE:
0.7224
HELIX:
0.0257
FCONS_SCORE:
0.9853
RIG_SCORE:
0.5717
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S2305I
DO229006
LICA
ICGC
SSETSHSVPEA
DEG_COP1_1
0.7341
p.S2306G
ACH-002027
Endometrial/Uterine Cancer
CCLE
SSETSHSVPEA
DEG_COP1_1
0.5882
Drug responses associated with SPEN mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SSETSHSVPEA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96T58
Msx2-interacting protein
DEG_COP1_1
2305:2315
SSETSHSVPEA
COP1
0.6961
More...