DegronMD - Q9ULD8(KCNH3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G933R	TCGA-05-4382	LUAD	TCGA	PASTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.3056
p.G933R	DO24900	LUAD	ICGC	PASTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.3056
p.G162C	TCGA-A6-5665	COAD	TCGA	SRAVLYHLS	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.1111
p.G162C	DO9756	COAD	ICGC	SRAVLYHLS	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.1111
p.D721Y	TCGA-AA-A010	COAD	TCGA	VDTSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.2222
p.S726Y	TCGA-CG-4437	STAD	TCGA	VDTSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.0833
p.S726Y	DO38467	STAD	ICGC	VDTSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.0833
p.R167W	TCGA-CK-5913	COAD	TCGA	SRAVLYHLS	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.25
p.R167W	DO8826	COAD	ICGC	SRAVLYHLS	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.25
p.R920Q	TCGA-CV-7432	HNSC	TCGA	PASTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1111
p.R920Q	DO14159	HNSC	ICGC	PASTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1111
p.R920Q	DO222363	MELA	ICGC	PASTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1111
p.R920W	TCGA-DK-A6B1	BLCA	TCGA	PASTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1111
p.R920W	DO48534	BLCA	ICGC	PASTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1111
p.R920W	DO222595	MELA	ICGC	PASTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1111
p.G707E	TCGA-DX-A3LS	SARC	TCGA	VDTSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1667
p.G707E	DO219965	SARC	ICGC	VDTSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1667
p.S710Y	TCGA-ER-A19C	SKCM	TCGA	VDTSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.25
p.S710Y	DO47353	SKCM	ICGC	VDTSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.25
p.A921V	TCGA-GC-A4ZW	BLCA	TCGA	PASTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1389
p.A921V	DO219024	BLCA	ICGC	PASTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1389
p.S930R	TCGA-SC-A6LN	MESO	TCGA	PASTS	DEG_SPOP_SBC_1	928:932	Mutation altering degron motif	0.7427
p.D721N	DO50444	ESAD	ICGC	VDTSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.2222
p.R171Q	DO228933	LICA	ICGC	SRAVLYHLS	DEG_APCC_DBOX_1	170:178	Mutation altering degron motif	0.7329
p.E924K	DO222843	MELA	ICGC	PASTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.2222
p.A706V	DO46973	RECA	ICGC	VDTSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1389
p.G179W	DO229211	THCA	ICGC	SRAVLYHLS	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.3056
p.V713G	SIDM00791	Chronic Myelogenous Leukemia	GDSC	VDTSS	DEG_SPOP_SBC_1	713:717	Mutation altering degron motif	0.7532
p.V713G	K-562	haematopoietic and lymphoid tissue	COSMIC	VDTSS	DEG_SPOP_SBC_1	713:717	Mutation altering degron motif	0.7532
p.A711S	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	VDTSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.2778
p.A711S	ACH-001233	Lung Cancer	CCLE	VDTSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.2778
p.A711S	VMRC-LCD	lung	COSMIC	VDTSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.2778
p.L938V	SIDM00571	Pancreatic Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1667
p.L938V	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1667
p.L938V	SIDM00989	Bladder Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1667
p.V940G	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1111
p.V940G	ACH-001489	Lung Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1111
p.V940G	COR-L32	lung	COSMIC	PASTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1111
p.G179R	SIDM00603	Head and Neck Carcinoma	GDSC	SRAVLYHLS	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.3056
p.G179R	ACH-001543	Head and Neck Cancer	CCLE	SRAVLYHLS	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.3056
p.N703K	SIDM01608	Endometrial Carcinoma	GDSC	VDTSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.0556
p.N703K	ACH-000990	Endometrial/Uterine Cancer	CCLE	VDTSS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.0556
p.L177M	ACH-001719	Ovarian Cancer	CCLE	SRAVLYHLS	DEG_APCC_DBOX_1	170:178	Mutation altering degron motif	0.5999
p.R169W	ACH-001834	Bile Duct Cancer	CCLE	SRAVLYHLS	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.3056
p.R169W	ACH-001835	Bile Duct Cancer	CCLE	SRAVLYHLS	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.3056
p.R169W	ACH-001836	Bile Duct Cancer	CCLE	SRAVLYHLS	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNH3

UniProt ID: Q9ULD8

Entrez ID: 23416

Protein name: Potassium voltage-gated channel subfamily H member 3 (Brain-specific eag-like channel 1) (BEC1) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Voltage-gated potassium channel subunit Kv12.2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNH3 in