DegronMD

Uniprot ID: Q9ULD8

Source protein: Potassium voltage-gated channel subfamily H member 3

Source gene: KCNH3

Class: DEG_APCC_DBOX_1

Location: 170:178

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.987

ASA_SCORE: 64.7222

COIL: 0.3767

CONS_SCORE: 0.4976

DSS_SCORE: 0.586

HELIX: 0.4569

FCONS_SCORE: 1.3827

RIG_SCORE: 0.7547

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G162C	TCGA-A6-5665	COAD	TCGA	SRAVLYHLS	DEG_APCC_DBOX_1	0.1111
p.G162C	DO9756	COAD	ICGC	SRAVLYHLS	DEG_APCC_DBOX_1	0.1111
p.R167W	TCGA-CK-5913	COAD	TCGA	SRAVLYHLS	DEG_APCC_DBOX_1	0.25
p.R167W	DO8826	COAD	ICGC	SRAVLYHLS	DEG_APCC_DBOX_1	0.25
p.R171Q	DO228933	LICA	ICGC	SRAVLYHLS	DEG_APCC_DBOX_1	0.7329
p.G179W	DO229211	THCA	ICGC	SRAVLYHLS	DEG_APCC_DBOX_1	0.3056
p.G179R	SIDM00603	Head and Neck Carcinoma	GDSC	SRAVLYHLS	DEG_APCC_DBOX_1	0.3056
p.G179R	ACH-001543	Head and Neck Cancer	CCLE	SRAVLYHLS	DEG_APCC_DBOX_1	0.3056
p.L177M	ACH-001719	Ovarian Cancer	CCLE	SRAVLYHLS	DEG_APCC_DBOX_1	0.5999
p.R169W	ACH-001834	Bile Duct Cancer	CCLE	SRAVLYHLS	DEG_APCC_DBOX_1	0.3056
p.R169W	ACH-001835	Bile Duct Cancer	CCLE	SRAVLYHLS	DEG_APCC_DBOX_1	0.3056
p.R169W	ACH-001836	Bile Duct Cancer	CCLE	SRAVLYHLS	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULD8	Potassium voltage-gated channel subfamily H member 3	DEG_APCC_DBOX_1	170:178	SRAVLYHLS	APC,CDC20,FZR1	0.987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons