DegronMD

Uniprot ID: Q9ULD8

Source protein: Potassium voltage-gated channel subfamily H member 3

Source gene: KCNH3

Class: DEG_SPOP_SBC_1

Location: 713:717

E3 ligase: SPOP

DEGRON score: 0.8379

ASA_SCORE: 76.12

COIL: 0.7482

CONS_SCORE: 0.2818

DSS_SCORE: 0.5874

HELIX: 0.185

FCONS_SCORE: 0.8022

RIG_SCORE: 0.7047

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D721Y	TCGA-AA-A010	COAD	TCGA	VDTSS	DEG_SPOP_SBC_1	0.2222
p.S726Y	TCGA-CG-4437	STAD	TCGA	VDTSS	DEG_SPOP_SBC_1	0.0833
p.S726Y	DO38467	STAD	ICGC	VDTSS	DEG_SPOP_SBC_1	0.0833
p.G707E	TCGA-DX-A3LS	SARC	TCGA	VDTSS	DEG_SPOP_SBC_1	0.1667
p.G707E	DO219965	SARC	ICGC	VDTSS	DEG_SPOP_SBC_1	0.1667
p.S710Y	TCGA-ER-A19C	SKCM	TCGA	VDTSS	DEG_SPOP_SBC_1	0.25
p.S710Y	DO47353	SKCM	ICGC	VDTSS	DEG_SPOP_SBC_1	0.25
p.D721N	DO50444	ESAD	ICGC	VDTSS	DEG_SPOP_SBC_1	0.2222
p.A706V	DO46973	RECA	ICGC	VDTSS	DEG_SPOP_SBC_1	0.1389
p.V713G	SIDM00791	Chronic Myelogenous Leukemia	GDSC	VDTSS	DEG_SPOP_SBC_1	0.7532
p.V713G	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	VDTSS	DEG_SPOP_SBC_1	0.7532
p.A711S	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	VDTSS	DEG_SPOP_SBC_1	0.2778
p.A711S	ACH-001233	Lung Cancer	CCLE	VDTSS	DEG_SPOP_SBC_1	0.2778
p.A711S	VMRC-LCD	lung	COSMIC	VDTSS	DEG_SPOP_SBC_1	0.2778
p.N703K	SIDM01608	Endometrial Carcinoma	GDSC	VDTSS	DEG_SPOP_SBC_1	0.0556
p.N703K	ACH-000990	Endometrial/Uterine Cancer	CCLE	VDTSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SPOP_SBC_1	1392:1396	VDTSS	SPOP	0.9909	More...
P06454	Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]	DEG_SPOP_SBC_1	6:10	VDTSS	SPOP	0.9544	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2313:2317	VDTSS	SPOP	0.5257	More...
P16435	NADPH--cytochrome P450 reductase	DEG_SPOP_SBC_1	6:10	VDTSS	SPOP	0.7465	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	2527:2531	VDTSS	SPOP	0.9726	More...
Q9C0D2	Centrosomal protein of 295 kDa	DEG_SPOP_SBC_1	1392:1396	VDTSS	SPOP	0.9888	More...
Q9H799	Ciliogenesis and planar polarity effector 1	DEG_SPOP_SBC_1	1985:1989	VDTSS	SPOP	0.9585	More...
Q9ULD8	Potassium voltage-gated channel subfamily H member 3	DEG_SPOP_SBC_1	713:717	VDTSS	SPOP	0.8379	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons