DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
VDTSS
Uniprot ID:
Q9C0D2
Source protein:
Centrosomal protein of 295 kDa
Source gene:
CEP295
Class:
DEG_SPOP_SBC_1
Location:
1392:1396
E3 ligase:
SPOP
DEGRON score:
0.9888
ASA_SCORE:
81.82
COIL:
0.8246
CONS_SCORE:
0.4584
DSS_SCORE:
0.5228
HELIX:
0.1516
FCONS_SCORE:
1.1524
RIG_SCORE:
0.6729
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CEP295 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VDTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95359
Transforming acidic coiled-coil-containing protein 2
DEG_SPOP_SBC_1
1392:1396
VDTSS
SPOP
0.9909
More...
P06454
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]
DEG_SPOP_SBC_1
6:10
VDTSS
SPOP
0.9544
More...
P12270
Nucleoprotein TPR
DEG_SPOP_SBC_1
2313:2317
VDTSS
SPOP
0.5257
More...
P16435
NADPH--cytochrome P450 reductase
DEG_SPOP_SBC_1
6:10
VDTSS
SPOP
0.7465
More...
Q96T58
Msx2-interacting protein
DEG_SPOP_SBC_1
2527:2531
VDTSS
SPOP
0.9726
More...
Q9C0D2
Centrosomal protein of 295 kDa
DEG_SPOP_SBC_1
1392:1396
VDTSS
SPOP
0.9888
More...
Q9H799
Ciliogenesis and planar polarity effector 1
DEG_SPOP_SBC_1
1985:1989
VDTSS
SPOP
0.9585
More...
Q9ULD8
Potassium voltage-gated channel subfamily H member 3
DEG_SPOP_SBC_1
713:717
VDTSS
SPOP
0.8379
More...