DegronMD

Uniprot ID: Q7Z6J6

Source protein: FERM domain-containing protein 5

Source gene: FRMD5

Class: DEG_SCF_FBW7_2

Location: 430:437

E3 ligase: FBXW7

DEGRON score: 0.8271

ASA_SCORE: 79.875

COIL: 0.7266

CONS_SCORE: 0.3125

DSS_SCORE: 0.3915

HELIX: 0.2509

FCONS_SCORE: 0.9647

RIG_SCORE: 0.7475

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P432T	TCGA-AP-A1DV	UCEC	TCGA	VLPTPVAE	DEG_SCF_FBW7_2	0.5919
p.P434L	TCGA-DA-A3F3	SKCM	TCGA	VLPTPVAE	DEG_SCF_FBW7_2	0.7582
p.E422K	TCGA-EO-A3AV	UCEC	TCGA	VLPTPVAE	DEG_SCF_FBW7_2	0.1111
p.E422K	TCGA-XF-AAMZ	BLCA	TCGA	VLPTPVAE	DEG_SCF_FBW7_2	0.1111
p.E441K	TCGA-UY-A78K	BLCA	TCGA	VLPTPVAE	DEG_SCF_FBW7_2	0.2222
p.P432S	SIDM00609	Kidney Carcinoma	GDSC	VLPTPVAE	DEG_SCF_FBW7_2	0.5641
p.P432S	SIDM01217	Other Blood Cancers	GDSC	VLPTPVAE	DEG_SCF_FBW7_2	0.5641
p.P432S	ACH-000250	Kidney Cancer	CCLE	VLPTPVAE	DEG_SCF_FBW7_2	0.5641
p.P432S	ACH-002276	Leukemia	CCLE	VLPTPVAE	DEG_SCF_FBW7_2	0.5641
p.P432S	KMRC-20	kidney	COSMIC	VLPTPVAE	DEG_SCF_FBW7_2	0.5641
p.P432S	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	VLPTPVAE	DEG_SCF_FBW7_2	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6J6	FERM domain-containing protein 5	DEG_SCF_FBW7_2	430:437	VLPTPVAE	FBXW7	0.8271	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons