DegronMD

Uniprot ID: O95696

Source protein: Bromodomain-containing protein 1

Source gene: BRD1

Class: LIG_APCC_ABBA_1

Location: 398:403

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9734

ASA_SCORE: 81.35

COIL: 0.8067

CONS_SCORE: 0.3674

DSS_SCORE: 0.3566

HELIX: 0.112

FCONS_SCORE: 0.9658

RIG_SCORE: 0.826

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N399Y	TCGA-36-2545	OV	TCGA	LNIYGD	LIG_APCC_ABBA_1	0.5948
p.N399Y	DO28015	OV	ICGC	LNIYGD	LIG_APCC_ABBA_1	0.5948
p.E405K	TCGA-B5-A0JY	UCEC	TCGA	LNIYGD	LIG_APCC_ABBA_1	0.2778
p.E405K	TCGA-BS-A0UF	UCEC	TCGA	LNIYGD	LIG_APCC_ABBA_1	0.2778
p.E405K	DO233767	GACA	ICGC	LNIYGD	LIG_APCC_ABBA_1	0.2778
p.E405K	DO229055	LICA	ICGC	LNIYGD	LIG_APCC_ABBA_1	0.2778
p.E405K	DO43041	UCEC	ICGC	LNIYGD	LIG_APCC_ABBA_1	0.2778
p.E405K	DO41488	UCEC	ICGC	LNIYGD	LIG_APCC_ABBA_1	0.2778
p.T389M	TCGA-CN-6012	HNSC	TCGA	LNIYGD	LIG_APCC_ABBA_1	0.0833
p.T389M	DO15743	HNSC	ICGC	LNIYGD	LIG_APCC_ABBA_1	0.0833
p.V410I	DO227549	COCA	ICGC	LNIYGD	LIG_APCC_ABBA_1	0.1389
p.D403G	DO234285	ESAD	ICGC	LNIYGD	LIG_APCC_ABBA_1	0.7198
p.D403G	SIDM00150	Colorectal Carcinoma	GDSC	LNIYGD	LIG_APCC_ABBA_1	0.7198
p.D403G	SIDM01766	Chondrosarcoma	GDSC	LNIYGD	LIG_APCC_ABBA_1	0.7198
p.G402R	DO233784	GACA	ICGC	LNIYGD	LIG_APCC_ABBA_1	0.6457
p.H388N	DO229018	LICA	ICGC	LNIYGD	LIG_APCC_ABBA_1	0.0556
p.L398R	DO52152	PAEN	ICGC	LNIYGD	LIG_APCC_ABBA_1	0.8428
p.V404A	SIDM00878	Breast Carcinoma	GDSC	LNIYGD	LIG_APCC_ABBA_1	0.3056
p.V404A	ACH-000930	Breast Cancer	CCLE	LNIYGD	LIG_APCC_ABBA_1	0.3056
p.V404A	HCC1569	breast	COSMIC	LNIYGD	LIG_APCC_ABBA_1	0.3056

Drug responses associated with BRD1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01045	UCEC\|endometrium	p.D993fs*1 (No)	GDSC	OF-1	24.595
SIDM00951	LAML\|acute_myeloid_leukaemia	p.S1026F (No)	GDSC	OF-1	32.483
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R550H (No)	GDSC	OF-1	32.483
SIDM00951	LAML\|acute_myeloid_leukaemia	p.C218* (No)	GDSC	OF-1	32.483
SIDM00145	ALL\|lymphoblastic_leukemia	p.G806R (No)	GDSC	OF-1	1.62
SIDM00145	ALL\|lymphoblastic_leukemia	p.D151N (No)	GDSC	OF-1	1.62
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.Q501K (No)	GDSC	OF-1	37.382
SIDM00683	PRAD\|prostate	p.M2T (No)	GDSC	OF-1	125.56
SIDM00334	UCEC\|endometrium	p.R468Q (No)	GDSC	OF-1	4.8628
SIDM00461	LAML\|acute_myeloid_leukaemia	p.A874S (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.R856L (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.R850H (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.A840T (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.N821H (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.K816N (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.K789N (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.D788A (No)	GDSC	OF-1	29.662
SIDM00527	COREAD\|large_intestine	p.A867V (No)	GDSC	OF-1	50.652
SIDM00669	PAAD\|pancreas	p.G806R (No)	GDSC	OF-1	45.845
SIDM00174	HNSC\|head_and_neck	p.V178A (No)	GDSC	OF-1	60.031
SIDM00537	COREAD\|large_intestine	p.K432fs*26 (No)	GDSC	OF-1	51.217
SIDM00971	BRCA\|breast	p.R1045H (No)	GDSC	OF-1	112.72
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.E976Q (No)	GDSC	OF-1	112.63
SIDM01088	UNCLASSIFIED\|endometrium	p.A383T (No)	GDSC	OF-1	9.243
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R91C (No)	GDSC	OF-1	44.461
SIDM01090	COREAD\|large_intestine	p.C217R (No)	GDSC	OF-1	53.326
SIDM00434	MM\|myeloma	p.R9Q (No)	GDSC	OF-1	17.906
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.R468Q (No)	GDSC	OF-1	18.418
SIDM00602	STAD\|stomach	p.R880C (No)	GDSC	OF-1	17.272
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.S17P (No)	GDSC	OF-1	64.916
SIDM00946	ALL\|T_cell_leukemia	p.A874S (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.R856L (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.R850H (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.A840T (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.N821H (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.K816N (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.K789N (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.D788A (No)	GDSC	OF-1	19.143
SIDM00249	ESCA\|oesophagus	p.S113L (No)	GDSC	OF-1	228.74
SIDM00590	HNSC\|head_and_neck	p.L633V (No)	GDSC	OF-1	22.51
SIDM00217	COREAD\|large_intestine	p.R974H (No)	GDSC	OF-1	46.7
SIDM00217	COREAD\|large_intestine	p.P566L (No)	GDSC	OF-1	46.7
SIDM00217	COREAD\|large_intestine	p.R536H (No)	GDSC	OF-1	46.7
SIDM00217	COREAD\|large_intestine	p.A442T (No)	GDSC	OF-1	46.7
SIDM00280	UNCLASSIFIED\|stomach	p.T1051S (No)	GDSC	OF-1	100.12
SIDM00933	BRCA\|breast	p.R850H (No)	GDSC	OF-1	35.829
SIDM00839	COREAD\|large_intestine	p.V241M (No)	GDSC	OF-1	96.444
SIDM00216	COREAD\|large_intestine	p.V1046I (No)	GDSC	OF-1	41.481
SIDM00216	COREAD\|large_intestine	p.V1032M (No)	GDSC	OF-1	41.481
SIDM00231	KIRC\|kidney	p.P691L (No)	GDSC	OF-1	110.29
SIDM00282	COREAD\|large_intestine	p.M362V (No)	GDSC	OF-1	42.633
SIDM00282	COREAD\|large_intestine	p.V248A (No)	GDSC	OF-1	42.633
SIDM00282	COREAD\|large_intestine	p.M236T (No)	GDSC	OF-1	42.633
SIDM00150	COREAD\|large_intestine	p.P606S (No)	GDSC	OF-1	206.7
SIDM00766	SCLC\|lung_small_cell_carcinoma	p.L65V (No)	GDSC	OF-1	78.694
SIDM00660	COREAD\|large_intestine	p.R847Q (No)	GDSC	OF-1	25.498
SIDM01000	SKCM\|melanoma	p.S858F (No)	GDSC	OF-1	193.21
SIDM01100	NB\|neuroblastoma	p.R504* (No)	GDSC	OF-1	85.001
SIDM00783	COREAD\|large_intestine	p.R880H (No)	GDSC	OF-1	25.54
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.R913K (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A909V (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A404E (Yes)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.F898Y (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A874S (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.R856L (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.R850H (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A840T (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N821H (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.K816N (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.E626D (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.E626A (No)	GDSC	OF-1	25.503
SIDM00878	BRCA\|breast	p.K432fs*26 (No)	GDSC	OF-1	161.05
SIDM00487	COREAD\|large_intestine	p.D630G (No)	GDSC	OF-1	80.95
SIDM00487	COREAD\|large_intestine	p.V335M (No)	GDSC	OF-1	80.95
SIDM00282	COREAD\|large_intestine	p.L492fs*21 (No)	GDSC	OF-1	42.633
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A871V (No)	GDSC	OF-1	43.479
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.M1006I (No)	GDSC	OF-1	134.7
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.T565A (No)	GDSC	OF-1	134.7
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R1029W (No)	GDSC	OF-1	37.771
SIDM00537	COREAD\|large_intestine	p.A1039T (No)	GDSC	OF-1	51.217
SIDM00878	BRCA\|breast	p.V404A (Yes)	GDSC	OF-1	161.05
SIDM00579	NB\|neuroblastoma	p.R9Q (No)	GDSC	OF-1	56.991
SIDM00796	UNCLASSIFIED\|head_and_neck	p.Q463E (No)	GDSC	OF-1	44.627
SIDM00118	COREAD\|large_intestine	p.T32A (No)	GDSC	OF-1	62.526
SIDM00860	HNSC\|head_and_neck	p.V1046A (No)	GDSC	OF-1	175.57
SIDM01144	STAD\|stomach	p.E102K (No)	GDSC	OF-1	27.071

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LNIYGD

Degron related mutations and impact score

Drug responses associated with BRD1 mutations

All proteins holding degron of LNIYGD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95696	Bromodomain-containing protein 1	LIG_APCC_ABBA_1	398:403	LNIYGD	APC,CDC20,FZR1	0.9734	More...