DegronMD

Uniprot ID: O95696

Source protein: Bromodomain-containing protein 1

Source gene: BRD1

Class: ITCH

Location: 136:139

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9995

ASA_SCORE: 75.25

COIL: 0.806

CONS_SCORE: 0.4196

DSS_SCORE: 0.3987

HELIX: 0.047

FCONS_SCORE: 1.0054

RIG_SCORE: 0.7465

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S131F	TCGA-29-1770	OV	TCGA	PPVY	ITCH	0.6389
p.S131F	DO31664	OV	ICGC	PPVY	ITCH	0.6389
p.A147T	TCGA-CD-A4MI	STAD	TCGA	PPVY	ITCH	0.1111
p.A147T	DO47717	STAD	ICGC	PPVY	ITCH	0.1111
p.P129L	TCGA-DA-A1HY	SKCM	TCGA	PPVY	ITCH	0.1389
p.P129L	DO37409	SKCM	ICGC	PPVY	ITCH	0.1389

Drug responses associated with BRD1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01045	UCEC\|endometrium	p.D993fs*1 (No)	GDSC	OF-1	24.595
SIDM00951	LAML\|acute_myeloid_leukaemia	p.S1026F (No)	GDSC	OF-1	32.483
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R550H (No)	GDSC	OF-1	32.483
SIDM00951	LAML\|acute_myeloid_leukaemia	p.C218* (No)	GDSC	OF-1	32.483
SIDM00145	ALL\|lymphoblastic_leukemia	p.G806R (No)	GDSC	OF-1	1.62
SIDM00145	ALL\|lymphoblastic_leukemia	p.D151N (No)	GDSC	OF-1	1.62
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.Q501K (No)	GDSC	OF-1	37.382
SIDM00683	PRAD\|prostate	p.M2T (No)	GDSC	OF-1	125.56
SIDM00334	UCEC\|endometrium	p.R468Q (No)	GDSC	OF-1	4.8628
SIDM00461	LAML\|acute_myeloid_leukaemia	p.A874S (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.R856L (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.R850H (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.A840T (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.N821H (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.K816N (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.K789N (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.D788A (No)	GDSC	OF-1	29.662
SIDM00527	COREAD\|large_intestine	p.A867V (No)	GDSC	OF-1	50.652
SIDM00669	PAAD\|pancreas	p.G806R (No)	GDSC	OF-1	45.845
SIDM00174	HNSC\|head_and_neck	p.V178A (No)	GDSC	OF-1	60.031
SIDM00537	COREAD\|large_intestine	p.K432fs*26 (No)	GDSC	OF-1	51.217
SIDM00971	BRCA\|breast	p.R1045H (No)	GDSC	OF-1	112.72
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.E976Q (No)	GDSC	OF-1	112.63
SIDM01088	UNCLASSIFIED\|endometrium	p.A383T (No)	GDSC	OF-1	9.243
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R91C (No)	GDSC	OF-1	44.461
SIDM01090	COREAD\|large_intestine	p.C217R (No)	GDSC	OF-1	53.326
SIDM00434	MM\|myeloma	p.R9Q (No)	GDSC	OF-1	17.906
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.R468Q (No)	GDSC	OF-1	18.418
SIDM00602	STAD\|stomach	p.R880C (No)	GDSC	OF-1	17.272
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.S17P (No)	GDSC	OF-1	64.916
SIDM00946	ALL\|T_cell_leukemia	p.A874S (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.R856L (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.R850H (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.A840T (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.N821H (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.K816N (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.K789N (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.D788A (No)	GDSC	OF-1	19.143
SIDM00249	ESCA\|oesophagus	p.S113L (No)	GDSC	OF-1	228.74
SIDM00590	HNSC\|head_and_neck	p.L633V (No)	GDSC	OF-1	22.51
SIDM00217	COREAD\|large_intestine	p.R974H (No)	GDSC	OF-1	46.7
SIDM00217	COREAD\|large_intestine	p.P566L (No)	GDSC	OF-1	46.7
SIDM00217	COREAD\|large_intestine	p.R536H (No)	GDSC	OF-1	46.7
SIDM00217	COREAD\|large_intestine	p.A442T (No)	GDSC	OF-1	46.7
SIDM00280	UNCLASSIFIED\|stomach	p.T1051S (No)	GDSC	OF-1	100.12
SIDM00933	BRCA\|breast	p.R850H (No)	GDSC	OF-1	35.829
SIDM00839	COREAD\|large_intestine	p.V241M (No)	GDSC	OF-1	96.444
SIDM00216	COREAD\|large_intestine	p.V1046I (No)	GDSC	OF-1	41.481
SIDM00216	COREAD\|large_intestine	p.V1032M (No)	GDSC	OF-1	41.481
SIDM00231	KIRC\|kidney	p.P691L (No)	GDSC	OF-1	110.29
SIDM00282	COREAD\|large_intestine	p.M362V (No)	GDSC	OF-1	42.633
SIDM00282	COREAD\|large_intestine	p.V248A (No)	GDSC	OF-1	42.633
SIDM00282	COREAD\|large_intestine	p.M236T (No)	GDSC	OF-1	42.633
SIDM00150	COREAD\|large_intestine	p.P606S (No)	GDSC	OF-1	206.7
SIDM00766	SCLC\|lung_small_cell_carcinoma	p.L65V (No)	GDSC	OF-1	78.694
SIDM00660	COREAD\|large_intestine	p.R847Q (No)	GDSC	OF-1	25.498
SIDM01000	SKCM\|melanoma	p.S858F (No)	GDSC	OF-1	193.21
SIDM01100	NB\|neuroblastoma	p.R504* (No)	GDSC	OF-1	85.001
SIDM00783	COREAD\|large_intestine	p.R880H (No)	GDSC	OF-1	25.54
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.R913K (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A909V (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A404E (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.F898Y (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A874S (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.R856L (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.R850H (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A840T (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N821H (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.K816N (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.E626D (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.E626A (No)	GDSC	OF-1	25.503
SIDM00878	BRCA\|breast	p.K432fs*26 (No)	GDSC	OF-1	161.05
SIDM00487	COREAD\|large_intestine	p.D630G (No)	GDSC	OF-1	80.95
SIDM00487	COREAD\|large_intestine	p.V335M (No)	GDSC	OF-1	80.95
SIDM00282	COREAD\|large_intestine	p.L492fs*21 (No)	GDSC	OF-1	42.633
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A871V (No)	GDSC	OF-1	43.479
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.M1006I (No)	GDSC	OF-1	134.7
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.T565A (No)	GDSC	OF-1	134.7
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R1029W (No)	GDSC	OF-1	37.771
SIDM00537	COREAD\|large_intestine	p.A1039T (No)	GDSC	OF-1	51.217
SIDM00878	BRCA\|breast	p.V404A (No)	GDSC	OF-1	161.05
SIDM00579	NB\|neuroblastoma	p.R9Q (No)	GDSC	OF-1	56.991
SIDM00796	UNCLASSIFIED\|head_and_neck	p.Q463E (No)	GDSC	OF-1	44.627
SIDM00118	COREAD\|large_intestine	p.T32A (No)	GDSC	OF-1	62.526
SIDM00860	HNSC\|head_and_neck	p.V1046A (No)	GDSC	OF-1	175.57
SIDM01144	STAD\|stomach	p.E102K (No)	GDSC	OF-1	27.071

All proteins holding degron of PPVY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NI15	Mesogenin-1	ITCH	152:155	PPVY	ITCH,NEDD4	0.9842	More...
O00358	Forkhead box protein E1	ITCH	209:212	PPVY	ITCH,NEDD4	0.6942	More...
O43760	Synaptogyrin-2	ITCH	221:224	PPVY	ITCH,NEDD4	0.9998	More...
O95696	Bromodomain-containing protein 1	ITCH	136:139	PPVY	ITCH,NEDD4	0.9995	More...
P05412	Transcription factor Jun	ITCH	167:170	PPVY	ITCH,NEDD4	0.9159	More...
P07202	Thyroid peroxidase	ITCH	178:181	PPVY	ITCH,NEDD4	0.6723	More...
P15311	Ezrin	ITCH	475:478	PPVY	ITCH,NEDD4	0.9955	More...
P16930	Fumarylacetoacetase	ITCH	187:190	PPVY	ITCH,NEDD4	0.9388	More...
P17275	Transcription factor JunB	ITCH	179:182	PPVY	ITCH,NEDD4	0.9876	More...
P19544	Wilms tumor protein	ITCH	197:200	PPVY	ITCH,NEDD4	0.9912	More...
P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ITCH	41:44	PPVY	ITCH,NEDD4	0.9981	More...
P51841	Retinal guanylyl cyclase 2	ITCH	768:771	PPVY	ITCH,NEDD4	0.5364	More...
Q14738	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	ITCH	529:532	PPVY	ITCH,NEDD4	0.9915	More...
Q5TD94	Radial spoke head protein 4 homolog A	ITCH	663:666	PPVY	ITCH,NEDD4	0.999	More...
Q8IWI9	MAX gene-associated protein	ITCH	1388:1391	PPVY	ITCH,NEDD4	0.9681	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	ITCH	1039:1042	PPVY	ITCH,NEDD4	0.9027	More...
Q8IYH5	ZZ-type zinc finger-containing protein 3	ITCH	752:755	PPVY	ITCH,NEDD4	0.9129	More...
Q8IZQ1	WD repeat and FYVE domain-containing protein 3	ITCH	819:822	PPVY	ITCH,NEDD4	0.8291	More...
Q8WUM4	Programmed cell death 6-interacting protein	ITCH	834:837	PPVY	ITCH,NEDD4	0.9847	More...
Q92738	USP6 N-terminal-like protein	ITCH	635:638	PPVY	ITCH,NEDD4	0.9985	More...
Q96HB5	Coiled-coil domain-containing protein 120	ITCH	489:492	PPVY	ITCH,NEDD4	0.9291	More...
Q96I25	Splicing factor 45	ITCH	211:214	PPVY	ITCH,NEDD4	0.997	More...
Q96L91	E1A-binding protein p400	ITCH	2281:2284	PPVY	ITCH,NEDD4	0.9976	More...
Q96ST3	Paired amphipathic helix protein Sin3a	ITCH	38:41	PPVY	ITCH,NEDD4	0.5288	More...
Q9BRR9	Rho GTPase-activating protein 9	ITCH	188:191	PPVY	ITCH,NEDD4	0.9955	More...
Q9BYN7	Zinc finger protein 341	ITCH	255:258	PPVY	ITCH,NEDD4	0.9224	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	ITCH	523:526	PPVY	ITCH,NEDD4	0.7929	More...
Q9UHG2	ProSAAS	ITCH	168:171	PPVY	ITCH,NEDD4	0.9983	More...
Q9UJ55	MAGE-like protein 2	ITCH	20:23	PPVY	ITCH,NEDD4	0.9909	More...
Q9UKI9	POU domain, class 2, transcription factor 3	ITCH	349:352	PPVY	ITCH,NEDD4	0.8894	More...
B8ZZ34	Protein shisa-8	ITCH	313:316	PPVY	ITCH,NEDD4	0.9544	More...
P59827	BPI fold-containing family B member 4	ITCH	72:75	PPVY	ITCH,NEDD4	0.993	More...
Q6PJG2	Mitotic deacetylase-associated SANT domain protein	ITCH	621:624	PPVY	ITCH,NEDD4	0.9954	More...
Q96DD7	Protein shisa-4	ITCH	176:179	PPVY	ITCH,NEDD4	0.8305	More...
Q9NZL6	Ral guanine nucleotide dissociation stimulator-like 1	ITCH	639:642	PPVY	ITCH,NEDD4	0.9944	More...
Q9P266	Junctional protein associated with coronary artery disease	ITCH	337:340	PPVY	ITCH,NEDD4	0.8881	More...
Q96ME7	Zinc finger protein 512	ITCH	147:150	PPVY	ITCH,NEDD4	0.8319	More...
Q9BXU3	Testis-expressed protein 13A	ITCH	371:374	PPVY	ITCH,NEDD4	0.6412	More...
Q9NWM3	CUE domain-containing protein 1	ITCH	128:131	PPVY	ITCH,NEDD4	0.9994	More...
A8MWL6	Putative synaptogyrin-2 like protein	ITCH	220:223	PPVY	ITCH,NEDD4	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPVY

Degron related mutations and impact score

Drug responses associated with BRD1 mutations

All proteins holding degron of PPVY