DegronMD - Q96ME7(ZNF512)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D370N	TCGA-09-0369	OV	TCGA	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.5821
p.R144L	TCGA-85-6561	LUSC	TCGA	PPVY	ITCH	147:150	Mutation rewiring degron network	0.25
p.R141S	TCGA-BF-A1Q0	SKCM	TCGA	PPVY	ITCH	147:150	Mutation rewiring degron network	0.1667
p.K145N	TCGA-BQ-7044	KIRP	TCGA	PPVY	ITCH	147:150	Mutation rewiring degron network	0.2778
p.K145N	DO20942	KIRP	ICGC	PPVY	ITCH	147:150	Mutation rewiring degron network	0.2778
p.D374A	TCGA-BS-A0UV	UCEC	TCGA	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2778
p.Q139K	TCGA-CR-7388	HNSC	TCGA	PPVY	ITCH	147:150	Mutation rewiring degron network	0.1111
p.T381A	TCGA-D8-A1Y1	BRCA	TCGA	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation blocking phosphorylation signal	0.5278
p.G153C	TCGA-EO-A22T	UCEC	TCGA	PPVY	ITCH	147:150	Mutation rewiring degron network	0.25
p.G153C	TCGA-FI-A2D5	UCEC	TCGA	PPVY	ITCH	147:150	Mutation rewiring degron network	0.25
p.R144W	TCGA-EY-A1GI	UCEC	TCGA	PPVY	ITCH	147:150	Mutation rewiring degron network	0.25
p.R144W	TCGA-F5-6814	READ	TCGA	PPVY	ITCH	147:150	Mutation rewiring degron network	0.25
p.R144W	SIDM01619	Endometrial Carcinoma	GDSC	PPVY	ITCH	147:150	Mutation rewiring degron network	0.25
p.R144W	ACH-000984	Endometrial/Uterine Cancer	CCLE	PPVY	ITCH	147:150	Mutation rewiring degron network	0.25
p.Q369E	TCGA-IR-A3LH	CESC	TCGA	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.5633
p.Q368E	DO44381	CESC	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.6744
p.R376C	DO234350	ESAD	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2222
p.R376C	DO222638	MELA	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2222
p.R376C	DO37406	SKCM	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2222
p.R376C	HCT-15	large intestine	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2222
p.S360I	DO229018	LICA	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation substituting flanking lysine	0.3333
p.S139N	DO231893	LINC	ICGC	PPVY	ITCH	147:150	Mutation rewiring degron network	0.1111
p.F359V	DO228616	MALY	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.1944
p.L382I	DO28024	OV	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0556
p.L367I	DO229232	THCA	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.7174
p.P362S	DO229232	THCA	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.2778
p.K157N	DO42312	UCEC	ICGC	PPVY	ITCH	147:150	Mutation rewiring degron network	0.1389
p.A381V	DO41235	UCEC	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation blocking phosphorylation signal	0.5278
p.S373A	DO41127	UCEC	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.3056
p.K364R	SIDM01016	T-Lymphoblastic Leukemia	GDSC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.6126
p.K364R	ACH-000995	Leukemia	CCLE	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.6126
p.K364R	Jurkat	haematopoietic and lymphoid tissue	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.6126
p.R365S	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.7427
p.R365S	ACH-001233	Lung Cancer	CCLE	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.7427
p.R365S	VMRC-LCD	lung	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.7427
p.R382L	SIDM00417	Plasma Cell Myeloma	GDSC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0556
p.R382L	SIDM00526	Chronic Myelogenous Leukemia	GDSC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0556
p.R382L	ACH-000072	Leukemia	CCLE	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0556
p.R382L	ACH-000626	Myeloma	CCLE	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0556
p.R382L	U-266	haematopoietic and lymphoid tissue	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0556
p.R382L	MEG-01	haematopoietic and lymphoid tissue	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.0556
p.E146K	SIDM00311	Mesothelioma	GDSC	PPVY	ITCH	147:150	Mutation rewiring degron network	0.3056
p.E146K	ACH-002133	Lung Cancer	CCLE	PPVY	ITCH	147:150	Mutation rewiring degron network	0.3056
p.E146K	H2810	pleura	COSMIC	PPVY	ITCH	147:150	Mutation rewiring degron network	0.3056
p.R364S	VMRC-LCD	lung	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.7427
p.K363R	Jurkat	haematopoietic and lymphoid tissue	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.3056
p.E145K	H2810	pleura	COSMIC	PPVY	ITCH	147:150	Mutation rewiring degron network	0.2778
p.L366I	HCC1419	breast	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation altering degron motif	0.7174
p.R381L	U-266	haematopoietic and lymphoid tissue	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation blocking phosphorylation signal	0.5278
p.R381L	MEG-01	haematopoietic and lymphoid tissue	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation blocking phosphorylation signal	0.5278
p.F359C	CHSA8926	bone	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	364:372	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF512

UniProt ID: Q96ME7

Entrez ID: 84450

Protein name: Zinc finger protein 512

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF512 in