DegronMD

Uniprot ID: Q96ME7

Source protein: Zinc finger protein 512

Source gene: ZNF512

Class: DEG_APCC_DBOX_1

Location: 364:372

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8578

ASA_SCORE: 113.4333

COIL: 0.6966

CONS_SCORE: 0.5415

DSS_SCORE: 0.2781

HELIX: 0.1122

FCONS_SCORE: 1.0379

RIG_SCORE: 0.8142

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D370N	TCGA-09-0369	OV	TCGA	KRKVLQDLV	DEG_APCC_DBOX_1	0.5821
p.D374A	TCGA-BS-A0UV	UCEC	TCGA	KRKVLQDLV	DEG_APCC_DBOX_1	0.2778
p.T381A	TCGA-D8-A1Y1	BRCA	TCGA	KRKVLQDLV	DEG_APCC_DBOX_1	0.5278
p.Q369E	TCGA-IR-A3LH	CESC	TCGA	KRKVLQDLV	DEG_APCC_DBOX_1	0.5633
p.Q368E	DO44381	CESC	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	0.6744
p.R376C	DO234350	ESAD	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	0.2222
p.R376C	DO222638	MELA	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	0.2222
p.R376C	DO37406	SKCM	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	0.2222
p.R376C	HCT-15	large_intestine	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	0.2222
p.S360I	DO229018	LICA	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	0.3333
p.F359V	DO228616	MALY	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	0.1944
p.L382I	DO28024	OV	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	0.0556
p.L367I	DO229232	THCA	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	0.7174
p.P362S	DO229232	THCA	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	0.2778
p.A381V	DO41235	UCEC	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	0.5278
p.S373A	DO41127	UCEC	ICGC	KRKVLQDLV	DEG_APCC_DBOX_1	0.3056
p.K364R	SIDM01016	T-Lymphoblastic Leukemia	GDSC	KRKVLQDLV	DEG_APCC_DBOX_1	0.6126
p.K364R	ACH-000995	Leukemia	CCLE	KRKVLQDLV	DEG_APCC_DBOX_1	0.6126
p.K364R	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	0.6126
p.R365S	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	KRKVLQDLV	DEG_APCC_DBOX_1	0.7427
p.R365S	ACH-001233	Lung Cancer	CCLE	KRKVLQDLV	DEG_APCC_DBOX_1	0.7427
p.R365S	VMRC-LCD	lung	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	0.7427
p.R382L	SIDM00417	Plasma Cell Myeloma	GDSC	KRKVLQDLV	DEG_APCC_DBOX_1	0.0556
p.R382L	SIDM00526	Chronic Myelogenous Leukemia	GDSC	KRKVLQDLV	DEG_APCC_DBOX_1	0.0556
p.R382L	ACH-000072	Leukemia	CCLE	KRKVLQDLV	DEG_APCC_DBOX_1	0.0556
p.R382L	ACH-000626	Myeloma	CCLE	KRKVLQDLV	DEG_APCC_DBOX_1	0.0556
p.R382L	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	0.0556
p.R382L	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	0.0556
p.R364S	VMRC-LCD	lung	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	0.7427
p.K363R	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	0.3056
p.L366I	HCC1419	breast	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	0.7174
p.R381L	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	0.5278
p.R381L	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	0.5278
p.F359C	CHSA8926	bone	COSMIC	KRKVLQDLV	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRKVLQDLV

Degron related mutations and impact score

Drug responses associated with ZNF512 mutations

All proteins holding degron of KRKVLQDLV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96ME7	Zinc finger protein 512	DEG_APCC_DBOX_1	364:372	KRKVLQDLV	APC,CDC20,FZR1	0.8578	More...