DegronMD - Q8IYH5(ZZZ3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G614A	TCGA-69-7979	LUAD	TCGA	DGESLSYSMLP	CBL_PTK	613:623	Mutation altering degron motif	0.6429
p.G614A	DO23874	LUAD	ICGC	DGESLSYSMLP	CBL_PTK	613:623	Mutation altering degron motif	0.6429
p.R762Q	TCGA-AA-A010	COAD	TCGA	PPVY	ITCH	752:755	Mutation rewiring degron network	0.1389
p.R762Q	TCGA-AZ-4315	COAD	TCGA	PPVY	ITCH	752:755	Mutation rewiring degron network	0.1389
p.R762Q	DO8842	COAD	ICGC	PPVY	ITCH	752:755	Mutation rewiring degron network	0.1389
p.E338K	TCGA-BR-8680	STAD	TCGA	CKENT	DEG_APCC_KENBOX_2	331:335	Mutation rewiring degron network	0.25
p.E338K	DO47769	STAD	ICGC	CKENT	DEG_APCC_KENBOX_2	331:335	Mutation rewiring degron network	0.25
p.E338K	ACH-002189	Kidney Cancer	CCLE	CKENT	DEG_APCC_KENBOX_2	331:335	Mutation rewiring degron network	0.25
p.P752L	TCGA-FG-6690	LGG	TCGA	PPVY	ITCH	752:755	Mutation altering degron motif	0.7582
p.P752L	DO22141	LGG	ICGC	PPVY	ITCH	752:755	Mutation altering degron motif	0.7582
p.K328Q	DO222762	COCA	ICGC	CKENT	DEG_APCC_KENBOX_2	331:335	Mutation substituting flanking lysine	0.3611
p.S606N	DO229050	LICA	ICGC	DGESLSYSMLP	CBL_PTK	613:623	Mutation blocking phosphorylation signal	0.5833
p.E629K	DO231022	LUSC	ICGC	DGESLSYSMLP	CBL_PTK	613:623	Mutation rewiring degron network	0.1667
p.S744P	ACH-000962	Ovarian Cancer	CCLE	PPVY	ITCH	752:755	Mutation rewiring degron network	0.1111
p.S744P	ACH-001145	Ovarian Cancer	CCLE	PPVY	ITCH	752:755	Mutation rewiring degron network	0.1111
p.E338G	ACH-000993	Endometrial/Uterine Cancer	CCLE	CKENT	DEG_APCC_KENBOX_2	331:335	Mutation rewiring degron network	0.25
p.L624F	ACH-001688	Kidney Cancer	CCLE	DGESLSYSMLP	CBL_PTK	613:623	Mutation rewiring degron network	0.3056

Kaplan plot for ZZZ3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZZZ3

UniProt ID: Q8IYH5

Entrez ID: 26009

Protein name: ZZ-type zinc finger-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZZZ3 in