DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DGESLSYSMLP
Uniprot ID:
Q8IYH5
Source protein:
ZZ-type zinc finger-containing protein 3
Source gene:
ZZZ3
Class:
CBL_PTK
Location:
613:623
E3 ligase:
CBL
DEGRON score:
0.9832
ASA_SCORE:
81.8636
COIL:
0.824
CONS_SCORE:
0.3497
DSS_SCORE:
0.6245
HELIX:
0.1165
FCONS_SCORE:
0.901
RIG_SCORE:
0.6637
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G614A
TCGA-69-7979
LUAD
TCGA
DGESLSYSMLP
CBL_PTK
0.6429
p.G614A
DO23874
LUAD
ICGC
DGESLSYSMLP
CBL_PTK
0.6429
p.S606N
DO229050
LICA
ICGC
DGESLSYSMLP
CBL_PTK
0.5833
p.E629K
DO231022
LUSC
ICGC
DGESLSYSMLP
CBL_PTK
0.1667
p.L624F
ACH-001688
Kidney Cancer
CCLE
DGESLSYSMLP
CBL_PTK
0.3056
Drug responses associated with ZZZ3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DGESLSYSMLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IYH5
ZZ-type zinc finger-containing protein 3
CBL_PTK
613:623
DGESLSYSMLP
CBL
0.9832
More...
