DegronMD

Uniprot ID: Q8IYH5

Source protein: ZZ-type zinc finger-containing protein 3

Source gene: ZZZ3

Class: DEG_APCC_KENBOX_2

Location: 331:335

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.805

ASA_SCORE: 101.84

COIL: 0.7428

CONS_SCORE: 0.3188

DSS_SCORE: 0.6857

HELIX: 0.217

FCONS_SCORE: 0.9929

RIG_SCORE: 0.6607

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E338K	TCGA-BR-8680	STAD	TCGA	CKENT	DEG_APCC_KENBOX_2	0.25
p.E338K	DO47769	STAD	ICGC	CKENT	DEG_APCC_KENBOX_2	0.25
p.E338K	ACH-002189	Kidney Cancer	CCLE	CKENT	DEG_APCC_KENBOX_2	0.25
p.K328Q	DO222762	COCA	ICGC	CKENT	DEG_APCC_KENBOX_2	0.3611
p.E338G	ACH-000993	Endometrial/Uterine Cancer	CCLE	CKENT	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYH5	ZZ-type zinc finger-containing protein 3	DEG_APCC_KENBOX_2	331:335	CKENT	APC,CDC20,FZR1	0.805	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons