DegronMD - Q9UJ55(MAGEL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q15K	TCGA-W5-AA36	CHOL	TCGA	PPVY	ITCH	20:23	Mutation rewiring degron network	0.1944
p.H22R	DO228324	BRCA	ICGC	PPVY	ITCH	20:23	Mutation altering degron motif	0.8244
p.A16D	DO229032	LICA	ICGC	PPVY	ITCH	20:23	Mutation rewiring degron network	0.2222
p.Q17K	DO26512	LUSC	ICGC	PPVY	ITCH	20:23	Mutation rewiring degron network	0.25
p.E31K	DO220851	MELA	ICGC	PPVY	ITCH	20:23	Mutation rewiring degron network	0.1111
p.H22Y	DO222727	MELA	ICGC	PPVY	ITCH	20:23	Mutation altering degron motif	0.7229
p.W14L	DO50664	ORCA	ICGC	PPVY	ITCH	20:23	Mutation rewiring degron network	0.1667
p.G719E	SIDM00392	Melanoma	GDSC	LMTPSGE	DEG_SCF_FBW7_2	714:720	Mutation altering degron motif	0.6087
p.P791Q	SIDM00120	Prostate Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	784:788	Mutation rewiring degron network	0.25
p.S725C	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	LMTPSGE	DEG_SCF_FBW7_2	714:720	Mutation rewiring degron network	0.1944
p.P798H	SIDM00927	Small Cell Lung Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	784:788	Mutation rewiring degron network	0.0556
p.P26S	ACH-000939	Sarcoma	CCLE	PPVY	ITCH	20:23	Mutation rewiring degron network	0.25
p.P26S	ACH-000967	Colon/Colorectal Cancer	CCLE	PPVY	ITCH	20:23	Mutation rewiring degron network	0.25
p.A29T	ACH-001274	Sarcoma	CCLE	PPVY	ITCH	20:23	Mutation rewiring degron network	0.1667
p.A29T	ACH-001399	Colon/Colorectal Cancer	CCLE	PPVY	ITCH	20:23	Mutation rewiring degron network	0.1667
p.A11V	ACH-001669	Leukemia	CCLE	PPVY	ITCH	20:23	Mutation rewiring degron network	0.0833
p.A11V	ACH-002238	Leukemia	CCLE	PPVY	ITCH	20:23	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons