DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LMTPSGE
Uniprot ID:
Q9UJ55
Source protein:
MAGE-like protein 2
Source gene:
MAGEL2
Class:
DEG_SCF_FBW7_2
Location:
714:720
E3 ligase:
FBXW7
DEGRON score:
0.5522
ASA_SCORE:
85.5143
COIL:
0.9013
CONS_SCORE:
0
DSS_SCORE:
0.556
HELIX:
0.0334
FCONS_SCORE:
0
RIG_SCORE:
0.6428
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G719E
SIDM00392
Melanoma
GDSC
LMTPSGE
DEG_SCF_FBW7_2
0.6087
p.S725C
SIDM00323
B-Cell Non-Hodgkin's Lymphoma
GDSC
LMTPSGE
DEG_SCF_FBW7_2
0.1944
Drug responses associated with MAGEL2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LMTPSGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UJ55
MAGE-like protein 2
DEG_SCF_FBW7_2
714:720
LMTPSGE
FBXW7
0.5522
More...