DegronMD - Q96I25(RBM17)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P212Q	TCGA-43-A474	LUSC	TCGA	PPVY	ITCH	211:214	Mutation altering degron motif	0.7035
p.P212Q	DO45490	LUSC	ICGC	PPVY	ITCH	211:214	Mutation altering degron motif	0.7035
p.E215K	TCGA-E7-A7XN	BLCA	TCGA	PPVY	ITCH	211:214	Mutation rewiring degron network	0.3056
p.E215K	DO51878	BLCA	ICGC	PPVY	ITCH	211:214	Mutation rewiring degron network	0.3056
p.P220L	DO225337	BRCA	ICGC	PPVY	ITCH	211:214	Mutation rewiring degron network	0.1667
p.K15T	DO229347	LAML	ICGC	MSLYDD	LIG_APCC_ABBA_1	1:6	Mutation substituting flanking lysine	0.1944
p.G8V	DO229027	LICA	ICGC	MSLYDD	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.2778
p.G8V	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	MSLYDD	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.2778
p.G8V	ACH-000945	Lung Cancer	CCLE	MSLYDD	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.2778
p.G8V	NCI-H650	lung	COSMIC	MSLYDD	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.2778
p.P212R	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	PPVY	ITCH	211:214	Mutation altering degron motif	0.7512
p.P212R	ACH-000562	Lung Cancer	CCLE	PPVY	ITCH	211:214	Mutation altering degron motif	0.7512
p.P212R	HCC-78	lung	COSMIC	PPVY	ITCH	211:214	Mutation altering degron motif	0.7512
p.T16R	ACH-000554	Breast Cancer	CCLE	MSLYDD	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons