DegronMD

Uniprot ID: Q96I25

Source protein: Splicing factor 45

Source gene: RBM17

Class: LIG_APCC_ABBA_1

Location: 1:6

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9989

ASA_SCORE: 53.6333

COIL: 0.741

CONS_SCORE: 0.5016

DSS_SCORE: 0.7148

HELIX: 0.1743

FCONS_SCORE: 1.3364

RIG_SCORE: 0.7885

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K15T	DO229347	LAML	ICGC	MSLYDD	LIG_APCC_ABBA_1	0.1944
p.G8V	DO229027	LICA	ICGC	MSLYDD	LIG_APCC_ABBA_1	0.2778
p.G8V	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	MSLYDD	LIG_APCC_ABBA_1	0.2778
p.G8V	ACH-000945	Lung Cancer	CCLE	MSLYDD	LIG_APCC_ABBA_1	0.2778
p.G8V	NCI-H650	lung	COSMIC	MSLYDD	LIG_APCC_ABBA_1	0.2778
p.T16R	ACH-000554	Breast Cancer	CCLE	MSLYDD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96I25	Splicing factor 45	LIG_APCC_ABBA_1	1:6	MSLYDD	APC,CDC20,FZR1	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons