DegronMD - Q8IZQ1(WDFY3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D829Y	TCGA-97-7546	LUAD	TCGA	PPVY	ITCH	819:822	Mutation rewiring degron network	0.1389
p.D829Y	DO23762	LUAD	ICGC	PPVY	ITCH	819:822	Mutation rewiring degron network	0.1389
p.R3242Q	TCGA-A5-A0VP	UCEC	TCGA	VPETPAPE	DEG_SCF_FBW7_2	3251:3258	Mutation rewiring degron network	0.0833
p.A3321T	TCGA-A5-A2K3	UCEC	TCGA	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation rewiring degron network	0.2222
p.A3321T	TCGA-EO-A22U	UCEC	TCGA	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation rewiring degron network	0.2222
p.G3327V	TCGA-AA-A00N	COAD	TCGA	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation altering degron motif	0.7532
p.G3327V	DO9876	COAD	ICGC	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation altering degron motif	0.7532
p.T3324A	TCGA-BR-4362	STAD	TCGA	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation blocking phosphorylation signal	0.75
p.T3324A	DO38336	STAD	ICGC	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation blocking phosphorylation signal	0.75
p.R3242W	TCGA-BR-8680	STAD	TCGA	VPETPAPE	DEG_SCF_FBW7_2	3251:3258	Mutation rewiring degron network	0.0833
p.R3242W	DO47769	STAD	ICGC	VPETPAPE	DEG_SCF_FBW7_2	3251:3258	Mutation rewiring degron network	0.0833
p.R3242W	SIDM01618	B-Lymphoblastic Leukemia	GDSC	VPETPAPE	DEG_SCF_FBW7_2	3251:3258	Mutation rewiring degron network	0.0833
p.R3242W	ACH-000942	Leukemia	CCLE	VPETPAPE	DEG_SCF_FBW7_2	3251:3258	Mutation rewiring degron network	0.0833
p.A3318T	TCGA-CS-5393	LGG	TCGA	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation rewiring degron network	0.1389
p.A3318T	TCGA-CS-5393	LGG	TCGA	PSSTS	DEG_SPOP_SBC_1	3304:3308	Mutation rewiring degron network	0.0556
p.R3312Q	TCGA-D1-A16O	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	3304:3308	Mutation rewiring degron network	0.2222
p.R3312Q	DO41169	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	3304:3308	Mutation rewiring degron network	0.2222
p.L830M	TCGA-DF-A2KU	UCEC	TCGA	PPVY	ITCH	819:822	Mutation rewiring degron network	0.1111
p.L830M	DO223286	UCEC	ICGC	PPVY	ITCH	819:822	Mutation rewiring degron network	0.1111
p.P824H	TCGA-EE-A2GE	SKCM	TCGA	PPVY	ITCH	819:822	Mutation rewiring degron network	0.2778
p.P824H	DO38016	SKCM	ICGC	PPVY	ITCH	819:822	Mutation rewiring degron network	0.2778
p.A828V	TCGA-EE-A3J5	SKCM	TCGA	PPVY	ITCH	819:822	Mutation rewiring degron network	0.1667
p.A828V	DO47331	SKCM	ICGC	PPVY	ITCH	819:822	Mutation rewiring degron network	0.1667
p.P3255S	TCGA-EJ-5518	PRAD	TCGA	VPETPAPE	DEG_SCF_FBW7_2	3251:3258	Mutation altering degron motif	0.6752
p.P3255S	DO36292	PRAD	ICGC	VPETPAPE	DEG_SCF_FBW7_2	3251:3258	Mutation altering degron motif	0.6752
p.P820T	TCGA-ER-A2NH	SKCM	TCGA	PPVY	ITCH	819:822	Mutation altering degron motif	0.7031
p.P820T	DO47683	SKCM	ICGC	PPVY	ITCH	819:822	Mutation altering degron motif	0.7031
p.R810T	TCGA-LN-A7HX	ESCA	TCGA	PPVY	ITCH	819:822	Mutation rewiring degron network	0.0833
p.S815F	TCGA-XF-A9SI	BLCA	TCGA	PPVY	ITCH	819:822	Mutation blocking phosphorylation signal	0.6667
p.S815F	DO51914	BLCA	ICGC	PPVY	ITCH	819:822	Mutation blocking phosphorylation signal	0.6667
p.I3330V	DO7798	COAD	ICGC	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation altering degron motif	0.7076
p.P823H	DO230309	COCA	ICGC	PPVY	ITCH	819:822	Mutation rewiring degron network	0.3056
p.A3301T	DO22129	LGG	ICGC	PSSTS	DEG_SPOP_SBC_1	3304:3308	Mutation rewiring degron network	0.25
p.T3307N	DO228925	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	3304:3308	Mutation altering degron motif	0.7055
p.Q3320K	DO228948	LICA	ICGC	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation rewiring degron network	0.1944
p.Q3266K	DO229035	LICA	ICGC	VPETPAPE	DEG_SCF_FBW7_2	3251:3258	Mutation rewiring degron network	0.1111
p.A3304S	DO230965	LUSC	ICGC	PSSTS	DEG_SPOP_SBC_1	3304:3308	Mutation altering degron motif	0.7588
p.A3304S	DO224599	LUSC	ICGC	PSSTS	DEG_SPOP_SBC_1	3304:3308	Mutation altering degron motif	0.7588
p.E3325D	DO26524	LUSC	ICGC	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation altering degron motif	0.6758
p.R3317H	DO228419	MALY	ICGC	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation rewiring degron network	0.1111
p.R3317H	DO228419	MALY	ICGC	PSSTS	DEG_SPOP_SBC_1	3304:3308	Mutation rewiring degron network	0.0833
p.R3317H	SIDM00329	Hodgkin's Lymphoma	GDSC	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation rewiring degron network	0.1111
p.R3317H	SIDM00329	Hodgkin's Lymphoma	GDSC	PSSTS	DEG_SPOP_SBC_1	3304:3308	Mutation rewiring degron network	0.0833
p.R3317H	ACH-000806	Lymphoma	CCLE	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation rewiring degron network	0.1111
p.R3317H	ACH-000806	Lymphoma	CCLE	PSSTS	DEG_SPOP_SBC_1	3304:3308	Mutation rewiring degron network	0.0833
p.R3317H	L-540	haematopoietic and lymphoid tissue	COSMIC	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation rewiring degron network	0.1111
p.R3317H	L-540	haematopoietic and lymphoid tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	3304:3308	Mutation rewiring degron network	0.0833
p.T818A	DO228604	PRAD	ICGC	PPVY	ITCH	819:822	Mutation blocking phosphorylation signal	0.75
p.D3319Y	DO36969	READ	ICGC	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation blocking phosphorylation signal	0.6111
p.A3304T	DO43899	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	3304:3308	Mutation altering degron motif	0.7139
p.A3304T	DO43755	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	3304:3308	Mutation altering degron motif	0.7139
p.P3304S	SIDM02050	Colorectal Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	3304:3308	Mutation altering degron motif	0.6752
p.N826H	SIDM00646	Small Cell Lung Carcinoma	GDSC	PPVY	ITCH	819:822	Mutation rewiring degron network	0.2222
p.N826H	ACH-000129	Lung Cancer	CCLE	PPVY	ITCH	819:822	Mutation rewiring degron network	0.2222
p.N826H	NCI-H1341	lung	COSMIC	PPVY	ITCH	819:822	Mutation rewiring degron network	0.2222
p.P819S	SIDM01175	Other Sarcomas	GDSC	PPVY	ITCH	819:822	Mutation altering degron motif	0.6752
p.P819S	SIDM00808	Burkitt's Lymphoma	GDSC	PPVY	ITCH	819:822	Mutation altering degron motif	0.6752
p.P819S	SIDM01254	Burkitt's Lymphoma	GDSC	PPVY	ITCH	819:822	Mutation altering degron motif	0.6752
p.T3319I	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation blocking phosphorylation signal	0.6111
p.T3319I	ACH-000861	Lung Cancer	CCLE	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation blocking phosphorylation signal	0.6111
p.T3319I	HOP-62	lung	COSMIC	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation blocking phosphorylation signal	0.6111
p.D3329H	SIDM01622	Breast Carcinoma	GDSC	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation altering degron motif	0.6577
p.D3329H	ACH-000721	Breast Cancer	CCLE	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation altering degron motif	0.6577
p.L3340I	SIDM01473	Plasma Cell Myeloma	GDSC	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation rewiring degron network	0.0833
p.L3340I	ACH-000541	Myeloma	CCLE	DSGSDDS	DEG_SCF_TRCP1_1	3325:3331	Mutation rewiring degron network	0.0833
p.R3312G	ACH-000512	Myeloma	CCLE	PSSTS	DEG_SPOP_SBC_1	3304:3308	Mutation rewiring degron network	0.2222
p.H814N	ACH-001991	Primary	CCLE	PPVY	ITCH	819:822	Mutation rewiring degron network	0.1944

Kaplan plot for WDFY3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDFY3

UniProt ID: Q8IZQ1

Entrez ID: 23001

Protein name: WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WDFY3 in