DegronMD

Uniprot ID: Q8IZQ1

Source protein: WD repeat and FYVE domain-containing protein 3

Source gene: WDFY3

Class: DEG_SCF_FBW7_2

Location: 3251:3258

E3 ligase: FBXW7

DEGRON score: 0.8429

ASA_SCORE: 87.975

COIL: 0.8359

CONS_SCORE: 0.2388

DSS_SCORE: 0.5357

HELIX: 0.0159

FCONS_SCORE: 0.8282

RIG_SCORE: 0.7092

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R3242Q	TCGA-A5-A0VP	UCEC	TCGA	VPETPAPE	DEG_SCF_FBW7_2	0.0833
p.R3242W	TCGA-BR-8680	STAD	TCGA	VPETPAPE	DEG_SCF_FBW7_2	0.0833
p.R3242W	DO47769	STAD	ICGC	VPETPAPE	DEG_SCF_FBW7_2	0.0833
p.R3242W	SIDM01618	B-Lymphoblastic Leukemia	GDSC	VPETPAPE	DEG_SCF_FBW7_2	0.0833
p.R3242W	ACH-000942	Leukemia	CCLE	VPETPAPE	DEG_SCF_FBW7_2	0.0833
p.P3255S	TCGA-EJ-5518	PRAD	TCGA	VPETPAPE	DEG_SCF_FBW7_2	0.6752
p.P3255S	DO36292	PRAD	ICGC	VPETPAPE	DEG_SCF_FBW7_2	0.6752
p.Q3266K	DO229035	LICA	ICGC	VPETPAPE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZQ1	WD repeat and FYVE domain-containing protein 3	DEG_SCF_FBW7_2	3251:3258	VPETPAPE	FBXW7	0.8429	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons