DegronMD

Uniprot ID: Q8IZQ1

Source protein: WD repeat and FYVE domain-containing protein 3

Source gene: WDFY3

Class: DEG_SCF_TRCP1_1

Location: 3325:3331

E3 ligase: BTRC

DEGRON score: 0.9986

ASA_SCORE: 74.7714

COIL: 0.7704

CONS_SCORE: 0.2546

DSS_SCORE: 0.3803

HELIX: 0.146

FCONS_SCORE: 1.0134

RIG_SCORE: 0.69

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3321T	TCGA-A5-A2K3	UCEC	TCGA	DSGSDDS	DEG_SCF_TRCP1_1	0.2222
p.A3321T	TCGA-EO-A22U	UCEC	TCGA	DSGSDDS	DEG_SCF_TRCP1_1	0.2222
p.G3327V	TCGA-AA-A00N	COAD	TCGA	DSGSDDS	DEG_SCF_TRCP1_1	0.7532
p.G3327V	DO9876	COAD	ICGC	DSGSDDS	DEG_SCF_TRCP1_1	0.7532
p.T3324A	TCGA-BR-4362	STAD	TCGA	DSGSDDS	DEG_SCF_TRCP1_1	0.75
p.T3324A	DO38336	STAD	ICGC	DSGSDDS	DEG_SCF_TRCP1_1	0.75
p.A3318T	TCGA-CS-5393	LGG	TCGA	DSGSDDS	DEG_SCF_TRCP1_1	0.1389
p.I3330V	DO7798	COAD	ICGC	DSGSDDS	DEG_SCF_TRCP1_1	0.7076
p.Q3320K	DO228948	LICA	ICGC	DSGSDDS	DEG_SCF_TRCP1_1	0.1944
p.E3325D	DO26524	LUSC	ICGC	DSGSDDS	DEG_SCF_TRCP1_1	0.6758
p.R3317H	DO228419	MALY	ICGC	DSGSDDS	DEG_SCF_TRCP1_1	0.1111
p.R3317H	SIDM00329	Hodgkin's Lymphoma	GDSC	DSGSDDS	DEG_SCF_TRCP1_1	0.1111
p.R3317H	ACH-000806	Lymphoma	CCLE	DSGSDDS	DEG_SCF_TRCP1_1	0.1111
p.R3317H	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSDDS	DEG_SCF_TRCP1_1	0.1111
p.D3319Y	DO36969	READ	ICGC	DSGSDDS	DEG_SCF_TRCP1_1	0.6111
p.T3319I	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	DSGSDDS	DEG_SCF_TRCP1_1	0.6111
p.T3319I	ACH-000861	Lung Cancer	CCLE	DSGSDDS	DEG_SCF_TRCP1_1	0.6111
p.T3319I	HOP-62	lung	COSMIC	DSGSDDS	DEG_SCF_TRCP1_1	0.6111
p.D3329H	SIDM01622	Breast Carcinoma	GDSC	DSGSDDS	DEG_SCF_TRCP1_1	0.6577
p.D3329H	ACH-000721	Breast Cancer	CCLE	DSGSDDS	DEG_SCF_TRCP1_1	0.6577
p.L3340I	SIDM01473	Plasma Cell Myeloma	GDSC	DSGSDDS	DEG_SCF_TRCP1_1	0.0833
p.L3340I	ACH-000541	Myeloma	CCLE	DSGSDDS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZQ1	WD repeat and FYVE domain-containing protein 3	DEG_SCF_TRCP1_1	3325:3331	DSGSDDS	BTRC	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons