DegronMD

Uniprot ID: A8MWL6

Source protein: Putative synaptogyrin-2 like protein

Source gene: -

Class: ITCH

Location: 220:223

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9995

ASA_SCORE: 78.875

COIL: 0.8308

CONS_SCORE: 0.6403

DSS_SCORE: 0.9443

HELIX: 0.0218

FCONS_SCORE: 1.4223

RIG_SCORE: 0.7274

Degron related mutations and impact score

Drug responses associated with - mutations

All proteins holding degron of PPVY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NI15	Mesogenin-1	ITCH	152:155	PPVY	ITCH,NEDD4	0.9842	More...
O00358	Forkhead box protein E1	ITCH	209:212	PPVY	ITCH,NEDD4	0.6942	More...
O43760	Synaptogyrin-2	ITCH	221:224	PPVY	ITCH,NEDD4	0.9998	More...
O95696	Bromodomain-containing protein 1	ITCH	136:139	PPVY	ITCH,NEDD4	0.9995	More...
P05412	Transcription factor Jun	ITCH	167:170	PPVY	ITCH,NEDD4	0.9159	More...
P07202	Thyroid peroxidase	ITCH	178:181	PPVY	ITCH,NEDD4	0.6723	More...
P15311	Ezrin	ITCH	475:478	PPVY	ITCH,NEDD4	0.9955	More...
P16930	Fumarylacetoacetase	ITCH	187:190	PPVY	ITCH,NEDD4	0.9388	More...
P17275	Transcription factor JunB	ITCH	179:182	PPVY	ITCH,NEDD4	0.9876	More...
P19544	Wilms tumor protein	ITCH	197:200	PPVY	ITCH,NEDD4	0.9912	More...
P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ITCH	41:44	PPVY	ITCH,NEDD4	0.9981	More...
P51841	Retinal guanylyl cyclase 2	ITCH	768:771	PPVY	ITCH,NEDD4	0.5364	More...
Q14738	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	ITCH	529:532	PPVY	ITCH,NEDD4	0.9915	More...
Q5TD94	Radial spoke head protein 4 homolog A	ITCH	663:666	PPVY	ITCH,NEDD4	0.999	More...
Q8IWI9	MAX gene-associated protein	ITCH	1388:1391	PPVY	ITCH,NEDD4	0.9681	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	ITCH	1039:1042	PPVY	ITCH,NEDD4	0.9027	More...
Q8IYH5	ZZ-type zinc finger-containing protein 3	ITCH	752:755	PPVY	ITCH,NEDD4	0.9129	More...
Q8IZQ1	WD repeat and FYVE domain-containing protein 3	ITCH	819:822	PPVY	ITCH,NEDD4	0.8291	More...
Q8WUM4	Programmed cell death 6-interacting protein	ITCH	834:837	PPVY	ITCH,NEDD4	0.9847	More...
Q92738	USP6 N-terminal-like protein	ITCH	635:638	PPVY	ITCH,NEDD4	0.9985	More...
Q96HB5	Coiled-coil domain-containing protein 120	ITCH	489:492	PPVY	ITCH,NEDD4	0.9291	More...
Q96I25	Splicing factor 45	ITCH	211:214	PPVY	ITCH,NEDD4	0.997	More...
Q96L91	E1A-binding protein p400	ITCH	2281:2284	PPVY	ITCH,NEDD4	0.9976	More...
Q96ST3	Paired amphipathic helix protein Sin3a	ITCH	38:41	PPVY	ITCH,NEDD4	0.5288	More...
Q9BRR9	Rho GTPase-activating protein 9	ITCH	188:191	PPVY	ITCH,NEDD4	0.9955	More...
Q9BYN7	Zinc finger protein 341	ITCH	255:258	PPVY	ITCH,NEDD4	0.9224	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	ITCH	523:526	PPVY	ITCH,NEDD4	0.7929	More...
Q9UHG2	ProSAAS	ITCH	168:171	PPVY	ITCH,NEDD4	0.9983	More...
Q9UJ55	MAGE-like protein 2	ITCH	20:23	PPVY	ITCH,NEDD4	0.9909	More...
Q9UKI9	POU domain, class 2, transcription factor 3	ITCH	349:352	PPVY	ITCH,NEDD4	0.8894	More...
B8ZZ34	Protein shisa-8	ITCH	313:316	PPVY	ITCH,NEDD4	0.9544	More...
P59827	BPI fold-containing family B member 4	ITCH	72:75	PPVY	ITCH,NEDD4	0.993	More...
Q6PJG2	Mitotic deacetylase-associated SANT domain protein	ITCH	621:624	PPVY	ITCH,NEDD4	0.9954	More...
Q96DD7	Protein shisa-4	ITCH	176:179	PPVY	ITCH,NEDD4	0.8305	More...
Q9NZL6	Ral guanine nucleotide dissociation stimulator-like 1	ITCH	639:642	PPVY	ITCH,NEDD4	0.9944	More...
Q9P266	Junctional protein associated with coronary artery disease	ITCH	337:340	PPVY	ITCH,NEDD4	0.8881	More...
Q96ME7	Zinc finger protein 512	ITCH	147:150	PPVY	ITCH,NEDD4	0.8319	More...
Q9BXU3	Testis-expressed protein 13A	ITCH	371:374	PPVY	ITCH,NEDD4	0.6412	More...
Q9NWM3	CUE domain-containing protein 1	ITCH	128:131	PPVY	ITCH,NEDD4	0.9994	More...
A8MWL6	Putative synaptogyrin-2 like protein	ITCH	220:223	PPVY	ITCH,NEDD4	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPVY

Degron related mutations and impact score

Drug responses associated with - mutations

All proteins holding degron of PPVY