DegronMD - Q9BRR9(ARHGAP9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S164Y	TCGA-17-Z022	LUAD	TCGA	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1667
p.L165I	TCGA-AD-6889	COAD	TCGA	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1389
p.T178K	TCGA-DI-A1BU	UCEC	TCGA	PPVY	ITCH	188:191	Mutation blocking phosphorylation signal	0.5
p.R163K	TCGA-ER-A193	SKCM	TCGA	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1944
p.R163K	ACH-002175	Lung Cancer	CCLE	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1944
p.R163K	NCI-H740	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1944
p.S151N	TCGA-VQ-A8P2	STAD	TCGA	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2778
p.Y161F	DO51927	BLCA	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation blocking phosphorylation signal	0.6944
p.R145C	DO1618	BRCA	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1111
p.R145C	DO3846	BRCA	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1111
p.R145C	DO10164	COAD	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1111
p.R145C	DO227709	COCA	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1111
p.R145C	DO12226	GBM	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1111
p.R145C	DO25669	LUAD	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1111
p.R145C	DO228626	PRAD	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1111
p.R145C	DO51391	PRAD	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1111
p.R145C	DO41097	UCEC	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1111
p.A159V	DO8786	COAD	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.3056
p.A143T	DO227802	COCA	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.0556
p.V157I	DO233207	GACA	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.7076
p.V157I	EKVX	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.7076
p.P149S	DO10992	GBM	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2222
p.L196F	DO48523	KIRP	ICGC	PPVY	ITCH	188:191	Mutation rewiring degron network	0.1944
p.S166A	DO225404	LAML	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation blocking phosphorylation signal	0.5556
p.S166A	NUGC-4	stomach	COSMIC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation blocking phosphorylation signal	0.5556
p.P158Q	DO229009	LICA	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.7035
p.H190Y	DO231618	LINC	ICGC	PPVY	ITCH	188:191	Mutation altering degron motif	0.7229
p.P201Q	DO23711	LUAD	ICGC	PPVY	ITCH	188:191	Mutation rewiring degron network	0.0556
p.P186Q	DO23907	LUAD	ICGC	PPVY	ITCH	188:191	Mutation blocking phosphorylation signal	0.7222
p.A199V	DO220885	MELA	ICGC	PPVY	ITCH	188:191	Mutation rewiring degron network	0.1111
p.G178S	DO228620	PRAD	ICGC	PPVY	ITCH	188:191	Mutation blocking phosphorylation signal	0.5
p.E164K	DO37406	SKCM	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1667
p.P168S	DO48665	SKCM	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.0556
p.P186T	DO233989	THCA	ICGC	PPVY	ITCH	188:191	Mutation blocking phosphorylation signal	0.7222
p.S192Y	DO40884	UCEC	ICGC	PPVY	ITCH	188:191	Mutation rewiring degron network	0.3056
p.F156V	DO41211	UCEC	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.7068
p.E165K	DO41404	UCEC	ICGC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1389
p.F189V	DO42673	UCEC	ICGC	PPVY	ITCH	188:191	Mutation altering degron motif	0.7068
p.V167G	SIDM01314	Colorectal Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.0833
p.S158A	SIDM00570	Gastric Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.7588
p.S158A	NUGC-4	stomach	COSMIC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.7588
p.I155T	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.7078
p.I155T	EKVX	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.7078
p.V149I	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2222
p.V149I	EKVX	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2222
p.F148L	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1944
p.F148L	EKVX	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1944
p.E156Q	SIDM00614	Hepatocellular Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.6744
p.E156Q	JHH-7	liver	COSMIC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.6744
p.S184F	SIDM01175	Other Sarcomas	GDSC	PPVY	ITCH	188:191	Mutation rewiring degron network	0.2222
p.S184F	SW684	soft tissue	COSMIC	PPVY	ITCH	188:191	Mutation rewiring degron network	0.2222
p.Q162K	SIDM00660	Colorectal Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2222
p.Q162K	LS-411N	large intestine	COSMIC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2222
p.R145Q	SIDM00523	Small Cell Lung Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1111
p.R145Q	DMS-53	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1111
p.P146H	SIDM00118	Colorectal Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1389
p.P146H	HCC2998	large intestine	COSMIC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1389
p.Q197H	SIDM01494	Glioblastoma	GDSC	PPVY	ITCH	188:191	Mutation rewiring degron network	0.1667
p.P146S	SIDM00500	Colorectal Carcinoma	GDSC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1389
p.P189S	ACH-000793	Gastric Cancer	CCLE	PPVY	ITCH	188:191	Mutation altering degron motif	0.6752
p.P189S	KATOIII	stomach	COSMIC	PPVY	ITCH	188:191	Mutation altering degron motif	0.6752
p.R198C	ACH-001991	Primary	CCLE	PPVY	ITCH	188:191	Mutation rewiring degron network	0.1389
p.P154H	HCC2998	large intestine	COSMIC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.7694
p.Q179R	GAK	skin	COSMIC	PPVY	ITCH	188:191	Mutation rewiring degron network	0.0833
p.A151G	NCI-H1703	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.2778
p.S192F	SW684	soft tissue	COSMIC	PPVY	ITCH	188:191	Mutation rewiring degron network	0.3056
p.F156L	EKVX	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.6981
p.R153Q	DMS-53	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation altering degron motif	0.7329
p.I163T	EKVX	lung	COSMIC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1944
p.E164Q	JHH-7	liver	COSMIC	LKPFQE	LIG_APCC_ABBA_1	153:158	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP9

UniProt ID: Q9BRR9

Entrez ID: 64333

Protein name: Rho GTPase-activating protein 9 (Rho-type GTPase-activating protein 9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP9 in