DegronMD

Uniprot ID: Q9BRR9

Source protein: Rho GTPase-activating protein 9

Source gene: ARHGAP9

Class: ITCH

Location: 188:191

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9955

ASA_SCORE: 71.925

COIL: 0.7565

CONS_SCORE: 0.4349

DSS_SCORE: 0.3876

HELIX: 0.0313

FCONS_SCORE: 1.045

RIG_SCORE: 0.7345

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H190Y	DO231618	LINC	ICGC	PPVY	ITCH	0.7229
p.P186Q	DO23907	LUAD	ICGC	PPVY	ITCH	0.7222
p.P186T	DO233989	THCA	ICGC	PPVY	ITCH	0.7222
p.F189V	DO42673	UCEC	ICGC	PPVY	ITCH	0.7068
p.P189S	ACH-000793	Gastric Cancer	CCLE	PPVY	ITCH	0.6752
p.P189S	KATOIII	stomach	COSMIC	PPVY	ITCH	0.6752
p.T178K	TCGA-DI-A1BU	UCEC	TCGA	PPVY	ITCH	0.5
p.G178S	DO228620	PRAD	ICGC	PPVY	ITCH	0.5
p.S192Y	DO40884	UCEC	ICGC	PPVY	ITCH	0.3056
p.S192F	SW684	soft_tissue	COSMIC	PPVY	ITCH	0.3056
p.S184F	SIDM01175	Other Sarcomas	GDSC	PPVY	ITCH	0.2222
p.S184F	SW684	soft_tissue	COSMIC	PPVY	ITCH	0.2222
p.L196F	DO48523	KIRP	ICGC	PPVY	ITCH	0.1944
p.Q197H	SIDM01494	Glioblastoma	GDSC	PPVY	ITCH	0.1667
p.R198C	ACH-001991	Primary	CCLE	PPVY	ITCH	0.1389
p.A199V	DO220885	MELA	ICGC	PPVY	ITCH	0.1111
p.Q179R	GAK	skin	COSMIC	PPVY	ITCH	0.0833
p.P201Q	DO23711	LUAD	ICGC	PPVY	ITCH	0.0556

Showing 1 to 18 of 18 entries

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Drug responses associated with ARHGAP9 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPVY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	ITCH	1039:1042	PPVY	ITCH,NEDD4	0.9027	More...
P59827	BPI fold-containing family B member 4	ITCH	72:75	PPVY	ITCH,NEDD4	0.993	More...
O95696	Bromodomain-containing protein 1	ITCH	136:139	PPVY	ITCH,NEDD4	0.9995	More...
P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ITCH	41:44	PPVY	ITCH,NEDD4	0.9981	More...
Q96HB5	Coiled-coil domain-containing protein 120	ITCH	489:492	PPVY	ITCH,NEDD4	0.9291	More...
Q9NWM3	CUE domain-containing protein 1	ITCH	128:131	PPVY	ITCH,NEDD4	0.9994	More...
Q96L91	E1A-binding protein p400	ITCH	2281:2284	PPVY	ITCH,NEDD4	0.9976	More...
P15311	Ezrin	ITCH	475:478	PPVY	ITCH,NEDD4	0.9955	More...
O00358	Forkhead box protein E1	ITCH	209:212	PPVY	ITCH,NEDD4	0.6942	More...
P16930	Fumarylacetoacetase	ITCH	187:190	PPVY	ITCH,NEDD4	0.9388	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	ITCH	523:526	PPVY	ITCH,NEDD4	0.7929	More...
Q9P266	Junctional protein associated with coronary artery disease	ITCH	337:340	PPVY	ITCH,NEDD4	0.8881	More...
Q9UJ55	MAGE-like protein 2	ITCH	20:23	PPVY	ITCH,NEDD4	0.9909	More...
Q8IWI9	MAX gene-associated protein	ITCH	1388:1391	PPVY	ITCH,NEDD4	0.9681	More...
A6NI15	Mesogenin-1	ITCH	152:155	PPVY	ITCH,NEDD4	0.9842	More...
Q6PJG2	Mitotic deacetylase-associated SANT domain protein	ITCH	621:624	PPVY	ITCH,NEDD4	0.9954	More...
Q96ST3	Paired amphipathic helix protein Sin3a	ITCH	38:41	PPVY	ITCH,NEDD4	0.5288	More...
Q9UKI9	POU domain, class 2, transcription factor 3	ITCH	349:352	PPVY	ITCH,NEDD4	0.8894	More...
Q8WUM4	Programmed cell death 6-interacting protein	ITCH	834:837	PPVY	ITCH,NEDD4	0.9847	More...
Q9UHG2	ProSAAS	ITCH	168:171	PPVY	ITCH,NEDD4	0.9983	More...
Q96DD7	Protein shisa-4	ITCH	176:179	PPVY	ITCH,NEDD4	0.8305	More...
B8ZZ34	Protein shisa-8	ITCH	313:316	PPVY	ITCH,NEDD4	0.9544	More...
A8MWL6	Putative synaptogyrin-2 like protein	ITCH	220:223	PPVY	ITCH,NEDD4	0.9995	More...
Q5TD94	Radial spoke head protein 4 homolog A	ITCH	663:666	PPVY	ITCH,NEDD4	0.999	More...
Q9NZL6	Ral guanine nucleotide dissociation stimulator-like 1	ITCH	639:642	PPVY	ITCH,NEDD4	0.9944	More...

Showing 1 to 25 of 40 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPVY

Degron related mutations and impact score

Drug responses associated with ARHGAP9 mutations

All proteins holding degron of PPVY