DegronMD - Q9UKI9(POU2F3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P158S	TCGA-38-4632	LUAD	TCGA	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.2778
p.P158S	TCGA-AP-A1DK	UCEC	TCGA	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.2778
p.P158S	DO233134	GACA	ICGC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.2778
p.P158S	DO23858	LUAD	ICGC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.2778
p.P158S	DO42033	UCEC	ICGC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.2778
p.P361S	TCGA-58-8387	LUSC	TCGA	PPVY	ITCH	349:352	Mutation rewiring degron network	0.0833
p.P361S	DO45445	LUSC	ICGC	PPVY	ITCH	349:352	Mutation rewiring degron network	0.0833
p.P361S	DO35132	PACA	ICGC	PPVY	ITCH	349:352	Mutation rewiring degron network	0.0833
p.P361S	SIDM01277	Esophageal Carcinoma	GDSC	PPVY	ITCH	349:352	Mutation rewiring degron network	0.0833
p.N342H	TCGA-85-8049	LUSC	TCGA	PPVY	ITCH	349:352	Mutation rewiring degron network	0.1389
p.D21N	TCGA-AA-3984	COAD	TCGA	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation blocking phosphorylation signal	0.7222
p.H154Y	TCGA-AJ-A3BH	UCEC	TCGA	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.1667
p.H154Y	TCGA-BR-4361	STAD	TCGA	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.1667
p.H154Y	DO38887	STAD	ICGC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.1667
p.H154Y	DO41638	UCEC	ICGC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.1667
p.N342D	TCGA-AP-A059	UCEC	TCGA	PPVY	ITCH	349:352	Mutation rewiring degron network	0.1389
p.R340Q	TCGA-AX-A1CE	UCEC	TCGA	PPVY	ITCH	349:352	Mutation rewiring degron network	0.0833
p.S160F	TCGA-D3-A51G	SKCM	TCGA	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation altering degron motif	0.7982
p.S160F	DO47700	SKCM	ICGC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation altering degron motif	0.7982
p.P351Q	TCGA-EE-A20F	SKCM	TCGA	PPVY	ITCH	349:352	Mutation altering degron motif	0.7035
p.D18N	TCGA-EE-A3AA	SKCM	TCGA	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.1944
p.E163K	TCGA-EE-A3J7	SKCM	TCGA	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation altering degron motif	0.7022
p.E163K	TCGA-KQ-A41R	BLCA	TCGA	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation altering degron motif	0.7022
p.E163K	DO223592	BLCA	ICGC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation altering degron motif	0.7022
p.E163K	DO48770	SKCM	ICGC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation altering degron motif	0.7022
p.K14T	TCGA-EY-A1GI	UCEC	TCGA	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation blocking phosphorylation signal	0.5278
p.S161A	TCGA-KQ-A41R	BLCA	TCGA	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation altering degron motif	0.7588
p.S161A	DO223592	BLCA	ICGC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation altering degron motif	0.7588
p.D37H	TCGA-MF-A522	LUSC	TCGA	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.1667
p.D24N	TCGA-W3-A828	SKCM	TCGA	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation altering degron motif	0.6932
p.D19N	DO9002	COAD	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.2222
p.H154R	DO229010	COCA	ICGC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.1667
p.H154R	DO229013	COCA	ICGC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.1667
p.H154R	DO229016	COCA	ICGC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.1667
p.H154R	DO229003	COCA	ICGC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.1667
p.H154R	DO229005	COCA	ICGC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.1667
p.G33E	DO11854	GBM	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.2778
p.D40Y	DO10880	GBM	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.0833
p.D40Y	ACH-000916	Lung Cancer	CCLE	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.0833
p.D40Y	NCI-H1573	lung	COSMIC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.0833
p.A346G	DO228288	LICA	ICGC	PPVY	ITCH	349:352	Mutation rewiring degron network	0.25
p.V17E	DO229050	LICA	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.1667
p.K339R	DO231075	LUSC	ICGC	PPVY	ITCH	349:352	Mutation rewiring degron network	0.0556
p.N340H	DO26890	LUSC	ICGC	PPVY	ITCH	349:352	Mutation rewiring degron network	0.0833
p.D35H	DO45526	LUSC	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.2222
p.R36Q	DO222395	MELA	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.1944
p.R36Q	SiHa	cervix	COSMIC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.1944
p.D16N	DO222632	MELA	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.1389
p.D16N	DO37571	SKCM	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.1389
p.G159R	DO232849	NACA	ICGC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.3056
p.T21M	DO35083	PACA	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation blocking phosphorylation signal	0.7222
p.Y352H	DO232761	PBCA	ICGC	PPVY	ITCH	349:352	Mutation altering degron motif	0.7229
p.S169F	DO229502	SKCA	ICGC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.2222
p.P349Q	DO37961	SKCM	ICGC	PPVY	ITCH	349:352	Mutation altering degron motif	0.7035
p.D22N	DO51273	SKCM	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.3056
p.N340D	DO41361	UCEC	ICGC	PPVY	ITCH	349:352	Mutation rewiring degron network	0.0833
p.R357Q	SIDM00845	Burkitt's Lymphoma	GDSC	PPVY	ITCH	349:352	Mutation rewiring degron network	0.1944
p.R357Q	SIDM01090	Colorectal Carcinoma	GDSC	PPVY	ITCH	349:352	Mutation rewiring degron network	0.1944
p.R26H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation altering degron motif	0.8244
p.R26H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation altering degron motif	0.8244
p.R38Q	SIDM01093	Cervical Carcinoma	GDSC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.1389
p.R38Q	SIDM01435	Hepatocellular Carcinoma	GDSC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.1389
p.R38Q	SiHa	cervix	COSMIC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.1389
p.P175S	SIDM00102	Mesothelioma	GDSC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.0556
p.P175S	H2461	pleura	COSMIC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.0556
p.P164H	SIDM01608	Endometrial Carcinoma	GDSC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation altering degron motif	0.7694
p.E33V	SIDM01664	Prostate Carcinoma	GDSC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation rewiring degron network	0.2778
p.P162H	ACH-000990	Endometrial/Uterine Cancer	CCLE	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation altering degron motif	0.7694
p.P173S	ACH-002125	Lung Cancer	CCLE	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.1111
p.P173S	H2461	pleura	COSMIC	LEPHLE	LIG_APCC_ABBA_1	160:165	Mutation rewiring degron network	0.1111
p.R24H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ARSTLSQVE	DEG_APCC_DBOX_1	23:31	Mutation altering degron motif	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POU2F3

UniProt ID: Q9UKI9

Entrez ID: 25833

Protein name: POU domain, class 2, transcription factor 3 (Octamer-binding protein 11) (Oct-11) (Octamer-binding transcription factor 11) (OTF-11) (Transcription factor PLA-1) (Transcription factor Skn-1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for POU2F3 in