DegronMD

Uniprot ID: Q9UKI9

Source protein: POU domain, class 2, transcription factor 3

Source gene: POU2F3

Class: DEG_APCC_DBOX_1

Location: 23:31

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8643

ASA_SCORE: 83.7778

COIL: 0.7939

CONS_SCORE: 0.2591

DSS_SCORE: 0.654

HELIX: 0.1406

FCONS_SCORE: 0.8875

RIG_SCORE: 0.6894

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D21N	TCGA-AA-3984	COAD	TCGA	ARSTLSQVE	DEG_APCC_DBOX_1	0.7222
p.D18N	TCGA-EE-A3AA	SKCM	TCGA	ARSTLSQVE	DEG_APCC_DBOX_1	0.1944
p.K14T	TCGA-EY-A1GI	UCEC	TCGA	ARSTLSQVE	DEG_APCC_DBOX_1	0.5278
p.D37H	TCGA-MF-A522	LUSC	TCGA	ARSTLSQVE	DEG_APCC_DBOX_1	0.1667
p.D24N	TCGA-W3-A828	SKCM	TCGA	ARSTLSQVE	DEG_APCC_DBOX_1	0.6932
p.D19N	DO9002	COAD	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	0.2222
p.G33E	DO11854	GBM	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	0.2778
p.D40Y	DO10880	GBM	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	0.0833
p.D40Y	ACH-000916	Lung Cancer	CCLE	ARSTLSQVE	DEG_APCC_DBOX_1	0.0833
p.D40Y	NCI-H1573	lung	COSMIC	ARSTLSQVE	DEG_APCC_DBOX_1	0.0833
p.V17E	DO229050	LICA	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	0.1667
p.D35H	DO45526	LUSC	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	0.2222
p.R36Q	DO222395	MELA	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	0.1944
p.R36Q	SiHa	cervix	COSMIC	ARSTLSQVE	DEG_APCC_DBOX_1	0.1944
p.D16N	DO222632	MELA	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	0.1389
p.D16N	DO37571	SKCM	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	0.1389
p.T21M	DO35083	PACA	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	0.7222
p.D22N	DO51273	SKCM	ICGC	ARSTLSQVE	DEG_APCC_DBOX_1	0.3056
p.R26H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ARSTLSQVE	DEG_APCC_DBOX_1	0.8244
p.R26H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ARSTLSQVE	DEG_APCC_DBOX_1	0.8244
p.R38Q	SIDM01093	Cervical Carcinoma	GDSC	ARSTLSQVE	DEG_APCC_DBOX_1	0.1389
p.R38Q	SIDM01435	Hepatocellular Carcinoma	GDSC	ARSTLSQVE	DEG_APCC_DBOX_1	0.1389
p.R38Q	SiHa	cervix	COSMIC	ARSTLSQVE	DEG_APCC_DBOX_1	0.1389
p.E33V	SIDM01664	Prostate Carcinoma	GDSC	ARSTLSQVE	DEG_APCC_DBOX_1	0.2778
p.R24H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ARSTLSQVE	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKI9	POU domain, class 2, transcription factor 3	DEG_APCC_DBOX_1	23:31	ARSTLSQVE	APC,CDC20,FZR1	0.8643	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARSTLSQVE

Degron related mutations and impact score

Drug responses associated with POU2F3 mutations

All proteins holding degron of ARSTLSQVE