DegronMD

Uniprot ID: Q9UKI9

Source protein: POU domain, class 2, transcription factor 3

Source gene: POU2F3

Class: LIG_APCC_ABBA_1

Location: 160:165

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8115

ASA_SCORE: 93.1333

COIL: 0.7447

CONS_SCORE: 0.4154

DSS_SCORE: 0.6846

HELIX: 0.2052

FCONS_SCORE: 1.1639

RIG_SCORE: 0.6173

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P158S	TCGA-38-4632	LUAD	TCGA	LEPHLE	LIG_APCC_ABBA_1	0.2778
p.P158S	TCGA-AP-A1DK	UCEC	TCGA	LEPHLE	LIG_APCC_ABBA_1	0.2778
p.P158S	DO233134	GACA	ICGC	LEPHLE	LIG_APCC_ABBA_1	0.2778
p.P158S	DO23858	LUAD	ICGC	LEPHLE	LIG_APCC_ABBA_1	0.2778
p.P158S	DO42033	UCEC	ICGC	LEPHLE	LIG_APCC_ABBA_1	0.2778
p.H154Y	TCGA-AJ-A3BH	UCEC	TCGA	LEPHLE	LIG_APCC_ABBA_1	0.1667
p.H154Y	TCGA-BR-4361	STAD	TCGA	LEPHLE	LIG_APCC_ABBA_1	0.1667
p.H154Y	DO38887	STAD	ICGC	LEPHLE	LIG_APCC_ABBA_1	0.1667
p.H154Y	DO41638	UCEC	ICGC	LEPHLE	LIG_APCC_ABBA_1	0.1667
p.S160F	TCGA-D3-A51G	SKCM	TCGA	LEPHLE	LIG_APCC_ABBA_1	0.7982
p.S160F	DO47700	SKCM	ICGC	LEPHLE	LIG_APCC_ABBA_1	0.7982
p.E163K	TCGA-EE-A3J7	SKCM	TCGA	LEPHLE	LIG_APCC_ABBA_1	0.7022
p.E163K	TCGA-KQ-A41R	BLCA	TCGA	LEPHLE	LIG_APCC_ABBA_1	0.7022
p.E163K	DO223592	BLCA	ICGC	LEPHLE	LIG_APCC_ABBA_1	0.7022
p.E163K	DO48770	SKCM	ICGC	LEPHLE	LIG_APCC_ABBA_1	0.7022
p.S161A	TCGA-KQ-A41R	BLCA	TCGA	LEPHLE	LIG_APCC_ABBA_1	0.7588
p.S161A	DO223592	BLCA	ICGC	LEPHLE	LIG_APCC_ABBA_1	0.7588
p.H154R	DO229010	COCA	ICGC	LEPHLE	LIG_APCC_ABBA_1	0.1667
p.H154R	DO229013	COCA	ICGC	LEPHLE	LIG_APCC_ABBA_1	0.1667
p.H154R	DO229016	COCA	ICGC	LEPHLE	LIG_APCC_ABBA_1	0.1667
p.H154R	DO229003	COCA	ICGC	LEPHLE	LIG_APCC_ABBA_1	0.1667
p.H154R	DO229005	COCA	ICGC	LEPHLE	LIG_APCC_ABBA_1	0.1667
p.G159R	DO232849	NACA	ICGC	LEPHLE	LIG_APCC_ABBA_1	0.3056
p.S169F	DO229502	SKCA	ICGC	LEPHLE	LIG_APCC_ABBA_1	0.2222
p.P175S	SIDM00102	Mesothelioma	GDSC	LEPHLE	LIG_APCC_ABBA_1	0.0556
p.P175S	H2461	pleura	COSMIC	LEPHLE	LIG_APCC_ABBA_1	0.0556
p.P164H	SIDM01608	Endometrial Carcinoma	GDSC	LEPHLE	LIG_APCC_ABBA_1	0.7694
p.P162H	ACH-000990	Endometrial/Uterine Cancer	CCLE	LEPHLE	LIG_APCC_ABBA_1	0.7694
p.P173S	ACH-002125	Lung Cancer	CCLE	LEPHLE	LIG_APCC_ABBA_1	0.1111
p.P173S	H2461	pleura	COSMIC	LEPHLE	LIG_APCC_ABBA_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LEPHLE

Degron related mutations and impact score

Drug responses associated with POU2F3 mutations

All proteins holding degron of LEPHLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKI9	POU domain, class 2, transcription factor 3	LIG_APCC_ABBA_1	160:165	LEPHLE	APC,CDC20,FZR1	0.8115	More...