DegronMD - Q96HB5(CCDC120)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S496N	TCGA-13-1494	OV	TCGA	PPVY	ITCH	489:492	Mutation rewiring degron network	0.2222
p.S496N	DO32698	OV	ICGC	PPVY	ITCH	489:492	Mutation rewiring degron network	0.2222
p.R400H	TCGA-55-8506	LUAD	TCGA	PQPTPAFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.3056
p.R400H	TCGA-AX-A2HC	UCEC	TCGA	PQPTPAFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.3056
p.R400H	DO228935	COCA	ICGC	PQPTPAFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.3056
p.R400H	DO45390	LUAD	ICGC	PQPTPAFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.3056
p.R400H	DO41572	UCEC	ICGC	PQPTPAFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.3056
p.R301Q	TCGA-A5-A2K5	UCEC	TCGA	VPATPVLT	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.2778
p.R301Q	DO41379	UCEC	ICGC	VPATPVLT	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.2778
p.R311W	TCGA-A5-A2K7	UCEC	TCGA	VPATPVLT	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.3056
p.R311W	DO41271	UCEC	ICGC	VPATPVLT	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.3056
p.P403L	TCGA-AA-3693	COAD	TCGA	PQPTPAFS	DEG_SCF_FBW7_1	401:408	Mutation altering degron motif	0.6471
p.P403L	DO9330	COAD	ICGC	PQPTPAFS	DEG_SCF_FBW7_1	401:408	Mutation altering degron motif	0.6471
p.R477L	TCGA-D7-A747	STAD	TCGA	RRDGLLTML	DEG_APCC_DBOX_1	477:485	Mutation altering degron motif	0.7316
p.R477L	DO51735	STAD	ICGC	RRDGLLTML	DEG_APCC_DBOX_1	477:485	Mutation altering degron motif	0.7316
p.E395K	DO225215	BRCA	ICGC	PQPTPAFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.1667
p.E395K	DO227836	BRCA	ICGC	PQPTPAFS	DEG_SCF_FBW7_1	401:408	Mutation rewiring degron network	0.1667
p.A570V	DO50090	COAD	ICGC	RRPVLPSVG	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.1944
p.R575C	DO233198	GACA	ICGC	RRPVLPSVG	DEG_APCC_DBOX_1	575:583	Mutation altering degron motif	0.719
p.R576W	DO233634	GACA	ICGC	RRPVLPSVG	DEG_APCC_DBOX_1	575:583	Mutation altering degron motif	0.8634
p.A570S	DO228929	LICA	ICGC	RRPVLPSVG	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.1944
p.L501F	DO228451	MALY	ICGC	PPVY	ITCH	489:492	Mutation rewiring degron network	0.0833
p.N566K	DO46344	OV	ICGC	RRPVLPSVG	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.0833
p.A592V	DO232732	PBCA	ICGC	RRPVLPSVG	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.0833
p.C318R	DO229268	THCA	ICGC	VPATPVLT	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.1111
p.R490H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPVY	ITCH	489:492	Mutation altering degron motif	0.8244
p.R490H	DND-41	haematopoietic and lymphoid tissue	COSMIC	PPVY	ITCH	489:492	Mutation altering degron motif	0.8244
p.R486W	SIDM00394	Cervical Carcinoma	GDSC	RRDGLLTML	DEG_APCC_DBOX_1	477:485	Mutation rewiring degron network	0.3056
p.R486W	SIDM00394	Cervical Carcinoma	GDSC	PPVY	ITCH	489:492	Mutation rewiring degron network	0.25
p.R486W	SISO	cervix	COSMIC	RRDGLLTML	DEG_APCC_DBOX_1	477:485	Mutation rewiring degron network	0.3056
p.R486W	SISO	cervix	COSMIC	PPVY	ITCH	489:492	Mutation rewiring degron network	0.25
p.D308N	SIDM00136	Colorectal Carcinoma	GDSC	VPATPVLT	DEG_SCF_FBW7_1	303:310	Mutation altering degron motif	0.6932
p.D308N	HT-29	large intestine	COSMIC	VPATPVLT	DEG_SCF_FBW7_1	303:310	Mutation altering degron motif	0.6932
p.C475R	SIDM00516	Melanoma	GDSC	RRDGLLTML	DEG_APCC_DBOX_1	477:485	Mutation rewiring degron network	0.2778
p.C475R	MZ7-mel	skin	COSMIC	RRDGLLTML	DEG_APCC_DBOX_1	477:485	Mutation rewiring degron network	0.2778
p.R576C	SIDM00357	Small Cell Lung Carcinoma	GDSC	RRPVLPSVG	DEG_APCC_DBOX_1	575:583	Mutation altering degron motif	0.8301
p.S579L	SIDM00373	Endometrial Carcinoma	GDSC	RRPVLPSVG	DEG_APCC_DBOX_1	575:583	Mutation altering degron motif	0.7667
p.R470Q	SIDM00431	T-Lymphoblastic Leukemia	GDSC	RRDGLLTML	DEG_APCC_DBOX_1	477:485	Mutation rewiring degron network	0.1389
p.R470Q	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	RRDGLLTML	DEG_APCC_DBOX_1	477:485	Mutation rewiring degron network	0.1389
p.W497C	SIDM01591	Breast Carcinoma	GDSC	PPVY	ITCH	489:492	Mutation rewiring degron network	0.1944
p.R593C	ACH-000301	Leukemia	CCLE	RRPVLPSVG	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.0556
p.T404I	ACH-000528	Lung Cancer	CCLE	PQPTPAFS	DEG_SCF_FBW7_1	401:408	Mutation altering degron motif	0.8189
p.L309I	ACH-000697	Lymphoma	CCLE	VPATPVLT	DEG_SCF_FBW7_1	303:310	Mutation altering degron motif	0.6063
p.P587L	ACH-000901	Lung Cancer	CCLE	RRPVLPSVG	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.2222
p.G312D	ACH-000966	Ovarian Cancer	CCLE	VPATPVLT	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.2778
p.R576Q	ACH-000967	Colon/Colorectal Cancer	CCLE	RRPVLPSVG	DEG_APCC_DBOX_1	575:583	Mutation altering degron motif	0.7329
p.E299Q	ACH-001690	Head and Neck Cancer	CCLE	VPATPVLT	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.2222
p.H591Q	ACH-001992	Primary	CCLE	RRPVLPSVG	DEG_APCC_DBOX_1	575:583	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC120

UniProt ID: Q96HB5

Entrez ID: 90060

Protein name: Coiled-coil domain-containing protein 120

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC120 in