DegronMD

Uniprot ID: Q96HB5

Source protein: Coiled-coil domain-containing protein 120

Source gene: CCDC120

Class: DEG_APCC_DBOX_1

Location: 575:583

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9785

ASA_SCORE: 97.1667

COIL: 0.9507

CONS_SCORE: 0.4846

DSS_SCORE: 0.5373

HELIX: 0.0209

FCONS_SCORE: 0.818

RIG_SCORE: 0.6448

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A570V	DO50090	COAD	ICGC	RRPVLPSVG	DEG_APCC_DBOX_1	0.1944
p.R575C	DO233198	GACA	ICGC	RRPVLPSVG	DEG_APCC_DBOX_1	0.719
p.R576W	DO233634	GACA	ICGC	RRPVLPSVG	DEG_APCC_DBOX_1	0.8634
p.A570S	DO228929	LICA	ICGC	RRPVLPSVG	DEG_APCC_DBOX_1	0.1944
p.N566K	DO46344	OV	ICGC	RRPVLPSVG	DEG_APCC_DBOX_1	0.0833
p.A592V	DO232732	PBCA	ICGC	RRPVLPSVG	DEG_APCC_DBOX_1	0.0833
p.R576C	SIDM00357	Small Cell Lung Carcinoma	GDSC	RRPVLPSVG	DEG_APCC_DBOX_1	0.8301
p.S579L	SIDM00373	Endometrial Carcinoma	GDSC	RRPVLPSVG	DEG_APCC_DBOX_1	0.7667
p.R593C	ACH-000301	Leukemia	CCLE	RRPVLPSVG	DEG_APCC_DBOX_1	0.0556
p.P587L	ACH-000901	Lung Cancer	CCLE	RRPVLPSVG	DEG_APCC_DBOX_1	0.2222
p.R576Q	ACH-000967	Colon/Colorectal Cancer	CCLE	RRPVLPSVG	DEG_APCC_DBOX_1	0.7329
p.H591Q	ACH-001992	Primary	CCLE	RRPVLPSVG	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HB5	Coiled-coil domain-containing protein 120	DEG_APCC_DBOX_1	575:583	RRPVLPSVG	APC,CDC20,FZR1	0.9785	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons