DegronMD

Uniprot ID: Q96HB5

Source protein: Coiled-coil domain-containing protein 120

Source gene: CCDC120

Class: DEG_SCF_FBW7_1

Location: 303:310

E3 ligase: FBXW7

DEGRON score: 0.9906

ASA_SCORE: 59.8375

COIL: 0.7304

CONS_SCORE: 0.9117

DSS_SCORE: 0.5844

HELIX: 0.0164

FCONS_SCORE: 1.1841

RIG_SCORE: 0.6945

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R301Q	TCGA-A5-A2K5	UCEC	TCGA	VPATPVLT	DEG_SCF_FBW7_1	0.2778
p.R301Q	DO41379	UCEC	ICGC	VPATPVLT	DEG_SCF_FBW7_1	0.2778
p.R311W	TCGA-A5-A2K7	UCEC	TCGA	VPATPVLT	DEG_SCF_FBW7_1	0.3056
p.R311W	DO41271	UCEC	ICGC	VPATPVLT	DEG_SCF_FBW7_1	0.3056
p.C318R	DO229268	THCA	ICGC	VPATPVLT	DEG_SCF_FBW7_1	0.1111
p.D308N	SIDM00136	Colorectal Carcinoma	GDSC	VPATPVLT	DEG_SCF_FBW7_1	0.6932
p.D308N	HT-29	large_intestine	COSMIC	VPATPVLT	DEG_SCF_FBW7_1	0.6932
p.L309I	ACH-000697	Lymphoma	CCLE	VPATPVLT	DEG_SCF_FBW7_1	0.6063
p.G312D	ACH-000966	Ovarian Cancer	CCLE	VPATPVLT	DEG_SCF_FBW7_1	0.2778
p.E299Q	ACH-001690	Head and Neck Cancer	CCLE	VPATPVLT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HB5	Coiled-coil domain-containing protein 120	DEG_SCF_FBW7_1	303:310	VPATPVLT	FBXW7	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons