DegronMD

Uniprot ID: Q96HB5

Source protein: Coiled-coil domain-containing protein 120

Source gene: CCDC120

Class: DEG_SCF_FBW7_1

Location: 401:408

E3 ligase: FBXW7

DEGRON score: 0.9387

ASA_SCORE: 88.8375

COIL: 0.9419

CONS_SCORE: 0.4639

DSS_SCORE: 0.6935

HELIX: 0.0276

FCONS_SCORE: 0.666

RIG_SCORE: 0.6181

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R400H	TCGA-55-8506	LUAD	TCGA	PQPTPAFS	DEG_SCF_FBW7_1	0.3056
p.R400H	TCGA-AX-A2HC	UCEC	TCGA	PQPTPAFS	DEG_SCF_FBW7_1	0.3056
p.R400H	DO228935	COCA	ICGC	PQPTPAFS	DEG_SCF_FBW7_1	0.3056
p.R400H	DO45390	LUAD	ICGC	PQPTPAFS	DEG_SCF_FBW7_1	0.3056
p.R400H	DO41572	UCEC	ICGC	PQPTPAFS	DEG_SCF_FBW7_1	0.3056
p.P403L	TCGA-AA-3693	COAD	TCGA	PQPTPAFS	DEG_SCF_FBW7_1	0.6471
p.P403L	DO9330	COAD	ICGC	PQPTPAFS	DEG_SCF_FBW7_1	0.6471
p.E395K	DO225215	BRCA	ICGC	PQPTPAFS	DEG_SCF_FBW7_1	0.1667
p.E395K	DO227836	BRCA	ICGC	PQPTPAFS	DEG_SCF_FBW7_1	0.1667
p.T404I	ACH-000528	Lung Cancer	CCLE	PQPTPAFS	DEG_SCF_FBW7_1	0.8189

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HB5	Coiled-coil domain-containing protein 120	DEG_SCF_FBW7_1	401:408	PQPTPAFS	FBXW7	0.9387	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons