DegronMD

Uniprot ID: Q96HB5

Source protein: Coiled-coil domain-containing protein 120

Source gene: CCDC120

Class: DEG_APCC_DBOX_1

Location: 477:485

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7191

ASA_SCORE: 84.6889

COIL: 0.8468

CONS_SCORE: 0.6115

DSS_SCORE: 0.5724

HELIX: 0.0887

FCONS_SCORE: 1.1094

RIG_SCORE: 0.7045

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R477L	TCGA-D7-A747	STAD	TCGA	RRDGLLTML	DEG_APCC_DBOX_1	0.7316
p.R477L	DO51735	STAD	ICGC	RRDGLLTML	DEG_APCC_DBOX_1	0.7316
p.R486W	SIDM00394	Cervical Carcinoma	GDSC	RRDGLLTML	DEG_APCC_DBOX_1	0.3056
p.R486W	SISO	cervix	COSMIC	RRDGLLTML	DEG_APCC_DBOX_1	0.3056
p.C475R	SIDM00516	Melanoma	GDSC	RRDGLLTML	DEG_APCC_DBOX_1	0.2778
p.C475R	MZ7-mel	skin	COSMIC	RRDGLLTML	DEG_APCC_DBOX_1	0.2778
p.R470Q	SIDM00431	T-Lymphoblastic Leukemia	GDSC	RRDGLLTML	DEG_APCC_DBOX_1	0.1389
p.R470Q	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	RRDGLLTML	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HB5	Coiled-coil domain-containing protein 120	DEG_APCC_DBOX_1	477:485	RRDGLLTML	APC,CDC20,FZR1	0.7191	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons