DegronMD - P19544(WT1)

GO - Biological processes (BP): adrenal cortex formation [GO:0035802]; adrenal gland development [GO:0030325]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye development [GO:0043010]; cardiac muscle cell fate commitment [GO:0060923]; cellular response to cAMP [GO:0071320]; cellular response to gonadotropin stimulus [GO:0071371]; diaphragm development [GO:0060539]; epithelial cell differentiation [GO:0030855]; germ cell development [GO:0007281]; glomerular basement membrane development [GO:0032836]; glomerular visceral epithelial cell differentiation [GO:0072112]; glomerulus development [GO:0032835]; gonad development [GO:0008406]; heart development [GO:0007507]; kidney development [GO:0001822]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; mesenchymal to epithelial transition [GO:0060231]; metanephric epithelium development [GO:0072207]; metanephric mesenchyme development [GO:0072075]; metanephric S-shaped body morphogenesis [GO:0072284]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of female gonad development [GO:2000195]; negative regulation of metanephric glomerular mesangial cell proliferation [GO:0072302]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA methylation [GO:1905643]; positive regulation of gene expression [GO:0010628]; positive regulation of heart growth [GO:0060421]; positive regulation of male gonad development [GO:2000020]; positive regulation of metanephric ureteric bud development [GO:2001076]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; posterior mesonephric tubule development [GO:0072166]; regulation of animal organ formation [GO:0003156]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA splicing [GO:0008380]; sex determination [GO:0007530]; thorax and anterior abdomen determination [GO:0007356]; tissue development [GO:0009888]; ureteric bud development [GO:0001657]; vasculogenesis [GO:0001570]; visceral serous pericardium development [GO:0061032] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A188E	TCGA-33-AASL	LUSC	TCGA	PPVY	ITCH	197:200	Mutation rewiring degron network	0.0833
p.A188E	DO219133	LUSC	ICGC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.0833
p.P210A	TCGA-44-2656	LUAD	TCGA	PPVY	ITCH	197:200	Mutation rewiring degron network	0.0556
p.P210A	DO26052	LUAD	ICGC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.0556
p.S204I	TCGA-AJ-A3EK	UCEC	TCGA	PPVY	ITCH	197:200	Mutation rewiring degron network	0.2222
p.S204I	DO41584	UCEC	ICGC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.2222
p.S255L	TCGA-AP-A1DV	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7667
p.M250L	TCGA-DD-AACP	LIHC	TCGA	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.2778
p.R194M	TCGA-EE-A29X	SKCM	TCGA	PPVY	ITCH	197:200	Mutation rewiring degron network	0.25
p.R194M	DO37595	SKCM	ICGC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.25
p.N198Y	TCGA-EE-A2GC	SKCM	TCGA	PPVY	ITCH	197:200	Mutation altering degron motif	0.7059
p.N198Y	DO37839	SKCM	ICGC	PPVY	ITCH	197:200	Mutation altering degron motif	0.7059
p.H242N	TCGA-RW-A8AZ	PCPG	TCGA	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0556
p.P200S	TCGA-WE-A8ZT	SKCM	TCGA	PPVY	ITCH	197:200	Mutation altering degron motif	0.6752
p.P200S	DO51290	SKCM	ICGC	PPVY	ITCH	197:200	Mutation altering degron motif	0.6752
p.Q208L	DO51889	BLCA	ICGC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.1111
p.R205H	DO3346	BRCA	ICGC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.1944
p.R205H	DO228123	EOPC	ICGC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.1944
p.R205H	DO49457	PACA	ICGC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.1944
p.R205H	DO234100	THCA	ICGC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.1944
p.A199V	DO233109	GACA	ICGC	PPVY	ITCH	197:200	Mutation altering degron motif	0.6936
p.T187I	DO233211	GACA	ICGC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.0556
p.K197M	DO228194	LICA	ICGC	PPVY	ITCH	197:200	Mutation altering degron motif	0.8062
p.C255S	DO228928	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7541
p.Q187K	DO228976	LICA	ICGC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.0556
p.P200T	DO229025	LICA	ICGC	PPVY	ITCH	197:200	Mutation altering degron motif	0.7031
p.T248K	DO229045	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation substituting flanking lysine	0.3333
p.T248K	DO23870	LUAD	ICGC	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation substituting flanking lysine	0.3333
p.K190E	DO50894	LICA	ICGC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.1389
p.S206P	DO48475	LIHC	ICGC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.1667
p.P191R	DO223917	LIHC	ICGC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.1667
p.Q193K	DO25498	LUAD	ICGC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.2222
p.H244Y	DO23874	LUAD	ICGC	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1111
p.D198Y	DO26025	LUAD	ICGC	PPVY	ITCH	197:200	Mutation altering degron motif	0.7325
p.K197R	DO45427	LUSC	ICGC	PPVY	ITCH	197:200	Mutation altering degron motif	0.7237
p.D198N	DO219144	LUSC	ICGC	PPVY	ITCH	197:200	Mutation altering degron motif	0.6932
p.A199T	DO221124	MALY	ICGC	PPVY	ITCH	197:200	Mutation altering degron motif	0.7139
p.R205C	DO222696	MELA	ICGC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.1944
p.R205C	CP66-MEL	skin	COSMIC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.1944
p.K251N	DO51407	PRAD	ICGC	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.3056
p.P197S	DO229459	SKCA	ICGC	PPVY	ITCH	197:200	Mutation altering degron motif	0.6752
p.P252S	DO50288	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.6752
p.R201Q	DO219466	SKCM	ICGC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.3056
p.F264L	DO47944	STAD	ICGC	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1111
p.T245A	DO229102	UTCA	ICGC	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1389
p.P266L	SIDM02035	Colorectal Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0556
p.R250Q	SIDM01007	T-Lymphoblastic Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.2778
p.R250Q	SIDM00889	Cervical Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.2778
p.R250Q	ACH-001333	Cervical Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.2778
p.R250Q	ACH-001573	Leukemia	CCLE	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.2778
p.R250Q	ACH-002256	Leukemia	CCLE	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.2778
p.R250Q	C-33-A	cervix	COSMIC	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.2778
p.R250Q	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.2778
p.K265N	ACH-000901	Lung Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0833
p.S204R	ACH-000979	Prostate Cancer	CCLE	PPVY	ITCH	197:200	Mutation rewiring degron network	0.2222
p.S204R	DU-145	prostate	COSMIC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.2222
p.R189K	ACH-002396	Bone Cancer	CCLE	PPVY	ITCH	197:200	Mutation rewiring degron network	0.1111
p.R189K	Sarc9371	bone	COSMIC	PPVY	ITCH	197:200	Mutation rewiring degron network	0.1111
p.P249T	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.25
p.P249T	MMAC-SF	skin	COSMIC	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.25
p.R266Q	ME-1	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0556
p.R266W	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0556

Kaplan plot for WT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WT1

UniProt ID: P19544

Entrez ID: 7490

Protein name: Wilms tumor protein (WT33)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WT1 in