DegronMD

Uniprot ID: P19544

Source protein: Wilms tumor protein

Source gene: WT1

Class: DEG_SPOP_SBC_1

Location: 252:256

E3 ligase: SPOP

DEGRON score: 0.8526

ASA_SCORE: 67.1

COIL: 0.8758

CONS_SCORE: 0.3529

DSS_SCORE: 0.4094

HELIX: 0.069

FCONS_SCORE: 0.9452

RIG_SCORE: 0.648

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S255L	TCGA-AP-A1DV	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	0.7667
p.C255S	DO228928	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	0.7541
p.P252S	DO50288	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	0.6752
p.T248K	DO229045	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	0.3333
p.T248K	DO23870	LUAD	ICGC	AGSSS	DEG_SPOP_SBC_1	0.3333
p.K251N	DO51407	PRAD	ICGC	AGSSS	DEG_SPOP_SBC_1	0.3056
p.M250L	TCGA-DD-AACP	LIHC	TCGA	AGSSS	DEG_SPOP_SBC_1	0.2778
p.R250Q	SIDM01007	T-Lymphoblastic Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	0.2778
p.R250Q	SIDM00889	Cervical Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	0.2778
p.R250Q	ACH-001333	Cervical Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	0.2778
p.R250Q	ACH-001573	Leukemia	CCLE	AGSSS	DEG_SPOP_SBC_1	0.2778
p.R250Q	ACH-002256	Leukemia	CCLE	AGSSS	DEG_SPOP_SBC_1	0.2778
p.R250Q	C-33-A	cervix	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.2778
p.R250Q	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.2778
p.P249T	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.25
p.P249T	MMAC-SF	skin	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.25
p.T245A	DO229102	UTCA	ICGC	AGSSS	DEG_SPOP_SBC_1	0.1389
p.H244Y	DO23874	LUAD	ICGC	AGSSS	DEG_SPOP_SBC_1	0.1111
p.F264L	DO47944	STAD	ICGC	AGSSS	DEG_SPOP_SBC_1	0.1111
p.K265N	ACH-000901	Lung Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	0.0833
p.H242N	TCGA-RW-A8AZ	PCPG	TCGA	AGSSS	DEG_SPOP_SBC_1	0.0556
p.P266L	SIDM02035	Colorectal Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	0.0556
p.R266Q	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.0556
p.R266W	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 24 of 24 entries

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Drug responses associated with WT1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of AGSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHB7	AF4/FMR2 family member 4	DEG_SPOP_SBC_1	138:142	AGSSS	SPOP	0.9944	More...
Q12797	Aspartyl/asparaginyl beta-hydroxylase	DEG_SPOP_SBC_1	25:29	AGSSS	SPOP	0.9939	More...
Q9Y4F5	Centrosomal protein of 170 kDa protein B	DEG_SPOP_SBC_1	1288:1292	AGSSS	SPOP	0.9988	More...
O75508	Claudin-11	DEG_SPOP_SBC_1	194:198	AGSSS	SPOP	0.8946	More...
Q9NQR7	Coiled-coil domain-containing protein 177	DEG_SPOP_SBC_1	185:189	AGSSS	SPOP	0.9844	More...
Q5VW00	DDB1- and CUL4-associated factor 12-like protein 2	DEG_SPOP_SBC_1	20:24	AGSSS	SPOP	0.9965	More...
Q9Y238	Deleted in lung and esophageal cancer protein 1	DEG_SPOP_SBC_1	31:35	AGSSS	SPOP	0.5085	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1376:1380	AGSSS	SPOP	0.9974	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	691:695	AGSSS	SPOP	0.9332	More...
O95071	E3 ubiquitin-protein ligase UBR5	DEG_SPOP_SBC_1	978:982	AGSSS	SPOP	0.9867	More...
Q96A65	Exocyst complex component 4	DEG_SPOP_SBC_1	250:254	AGSSS	SPOP	0.9981	More...
P85037	Forkhead box protein K1	DEG_SPOP_SBC_1	261:265	AGSSS	SPOP	0.9927	More...
Q9BX10	GTP-binding protein 2	DEG_SPOP_SBC_1	30:34	AGSSS	SPOP	0.9919	More...
Q92831	Histone acetyltransferase KAT2B	DEG_SPOP_SBC_1	408:412	AGSSS	SPOP	0.9856	More...
O95251	Histone acetyltransferase KAT7	DEG_SPOP_SBC_1	8:12	AGSSS	SPOP	0.9992	More...
Q86YZ3	Hornerin	DEG_SPOP_SBC_1	511:515	AGSSS	SPOP	0.9551	More...
O60303	Katanin-interacting protein	DEG_SPOP_SBC_1	861:865	AGSSS	SPOP	0.9839	More...
P05787	Keratin, type II cytoskeletal 8	DEG_SPOP_SBC_1	447:451	AGSSS	SPOP	0.9964	More...
Q96JM4	Leucine-rich repeat and IQ domain-containing protein 1	DEG_SPOP_SBC_1	1709:1713	AGSSS	SPOP	0.7232	More...
Q16644	MAP kinase-activated protein kinase 3	DEG_SPOP_SBC_1	370:374	AGSSS	SPOP	0.8767	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SPOP_SBC_1	792:796	AGSSS	SPOP	0.987	More...
P43362	Melanoma-associated antigen 9	DEG_SPOP_SBC_1	52:56	AGSSS	SPOP	0.9728	More...
Q9P267	Methyl-CpG-binding domain protein 5	DEG_SPOP_SBC_1	546:550	AGSSS	SPOP	0.9719	More...
Q8N3F8	MICAL-like protein 1	DEG_SPOP_SBC_1	334:338	AGSSS	SPOP	0.9856	More...
Q86VE0	Myb-related transcription factor, partner of profilin	DEG_SPOP_SBC_1	174:178	AGSSS	SPOP	0.9993	More...

Showing 1 to 25 of 55 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AGSSS

Degron related mutations and impact score

Drug responses associated with WT1 mutations

All proteins holding degron of AGSSS