DegronMD

Uniprot ID: Q9P267

Source protein: Methyl-CpG-binding domain protein 5

Source gene: MBD5

Class: DEG_SPOP_SBC_1

Location: 546:550

E3 ligase: SPOP

DEGRON score: 0.9719

ASA_SCORE: 70.46

COIL: 0.9346

CONS_SCORE: 0.3854

DSS_SCORE: 0.4235

HELIX: 0.0462

FCONS_SCORE: 0.7781

RIG_SCORE: 0.6047

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S537C	TCGA-78-7161	LUAD	TCGA	AGSSS	DEG_SPOP_SBC_1	0.0833
p.S537C	DO25975	LUAD	ICGC	AGSSS	DEG_SPOP_SBC_1	0.0833
p.F541I	TCGA-AG-A036	READ	TCGA	AGSSS	DEG_SPOP_SBC_1	0.1944
p.F541I	DO37245	READ	ICGC	AGSSS	DEG_SPOP_SBC_1	0.1944
p.G547V	TCGA-AR-A0TZ	BRCA	TCGA	AGSSS	DEG_SPOP_SBC_1	0.6421
p.G547V	DO2287	BRCA	ICGC	AGSSS	DEG_SPOP_SBC_1	0.6421
p.P536T	TCGA-GN-A26C	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	0.0556
p.P536T	DO37782	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	0.0556
p.P536T	SIDM00217	Colorectal Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	0.0556
p.P536T	ACH-000999	Colon/Colorectal Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	0.0556
p.P536T	SNU-1040	large_intestine	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.0556
p.A544V	DO225337	BRCA	ICGC	AGSSS	DEG_SPOP_SBC_1	0.2778
p.S548R	DO234233	ESAD	ICGC	AGSSS	DEG_SPOP_SBC_1	0.7427
p.V551L	DO222557	MELA	ICGC	AGSSS	DEG_SPOP_SBC_1	0.3056
p.S545P	SIDM00845	Burkitt's Lymphoma	GDSC	AGSSS	DEG_SPOP_SBC_1	0.3056
p.S545P	SIDM00035	Thyroid Gland Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	0.3056
p.S545P	SIDM00461	Acute Myeloid Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	0.3056
p.S545P	SIDM00946	T-Lymphoblastic Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	0.3056
p.S545P	SIDM01519	Head and Neck Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	0.3056
p.S545P	ACH-000786	Lymphoma	CCLE	AGSSS	DEG_SPOP_SBC_1	0.3056
p.S545P	ACH-000992	Head and Neck Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	0.3056
p.S545P	ACH-001067	Brain Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	0.3056
p.S545P	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.3056
p.S545P	S-117	soft_tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.3056
p.S545P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.3056
p.S545P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.3056
p.S548N	SIDM00845	Burkitt's Lymphoma	GDSC	AGSSS	DEG_SPOP_SBC_1	0.7069
p.S548N	SIDM00035	Thyroid Gland Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	0.7069
p.S548N	SIDM00461	Acute Myeloid Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	0.7069
p.S548N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	0.7069
p.S548N	SIDM01519	Head and Neck Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	0.7069
p.S548N	ACH-000786	Lymphoma	CCLE	AGSSS	DEG_SPOP_SBC_1	0.7069
p.S548N	ACH-000992	Head and Neck Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	0.7069
p.S548N	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.7069
p.S548N	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.7069
p.S548N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.7069
p.S548N	S-117	soft_tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.7069
p.S549G	SIDM00845	Burkitt's Lymphoma	GDSC	AGSSS	DEG_SPOP_SBC_1	0.6993
p.S549G	SIDM00035	Thyroid Gland Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	0.6993
p.S549G	SIDM00461	Acute Myeloid Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	0.6993
p.S549G	SIDM00946	T-Lymphoblastic Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	0.6993
p.S549G	SIDM01519	Head and Neck Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	0.6993
p.S549G	ACH-000786	Lymphoma	CCLE	AGSSS	DEG_SPOP_SBC_1	0.6993
p.S549G	ACH-000992	Head and Neck Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	0.6993
p.S549G	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.6993
p.S549G	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.6993
p.S549G	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.6993
p.S549G	S-117	soft_tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	0.6993
p.G547R	SIDM00447	B-Lymphoblastic Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	0.6457
p.G547R	ACH-000960	Leukemia	CCLE	AGSSS	DEG_SPOP_SBC_1	0.6457
p.P536A	SIDM01336	Glioblastoma	GDSC	AGSSS	DEG_SPOP_SBC_1	0.0556
p.P536A	ACH-000368	Brain Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15391	Transcription factor YY2	DEG_SPOP_SBC_1	158:162	AGSSS	SPOP	0.8696	More...
O60303	Katanin-interacting protein	DEG_SPOP_SBC_1	861:865	AGSSS	SPOP	0.9839	More...
O75508	Claudin-11	DEG_SPOP_SBC_1	194:198	AGSSS	SPOP	0.8946	More...
O95071	E3 ubiquitin-protein ligase UBR5	DEG_SPOP_SBC_1	978:982	AGSSS	SPOP	0.9867	More...
O95251	Histone acetyltransferase KAT7	DEG_SPOP_SBC_1	8:12	AGSSS	SPOP	0.9992	More...
P05787	Keratin, type II cytoskeletal 8	DEG_SPOP_SBC_1	447:451	AGSSS	SPOP	0.9964	More...
P12036	Neurofilament heavy polypeptide	DEG_SPOP_SBC_1	41:45	AGSSS	SPOP	0.9916	More...
P19544	Wilms tumor protein	DEG_SPOP_SBC_1	252:256	AGSSS	SPOP	0.8526	More...
P40424	Pre-B-cell leukemia transcription factor 1	DEG_SPOP_SBC_1	332:336	AGSSS	SPOP	0.9911	More...
P57086	SCAN domain-containing protein 1	DEG_SPOP_SBC_1	25:29	AGSSS	SPOP	0.9956	More...
P85037	Forkhead box protein K1	DEG_SPOP_SBC_1	261:265	AGSSS	SPOP	0.9927	More...
Q12797	Aspartyl/asparaginyl beta-hydroxylase	DEG_SPOP_SBC_1	25:29	AGSSS	SPOP	0.9939	More...
Q12967	Ral guanine nucleotide dissociation stimulator	DEG_SPOP_SBC_1	712:716	AGSSS	SPOP	0.9334	More...
Q13190	Syntaxin-5	DEG_SPOP_SBC_1	31:35	AGSSS	SPOP	0.9924	More...
Q13761	Runt-related transcription factor 3	DEG_SPOP_SBC_1	347:351	AGSSS	SPOP	0.9358	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	766:770	AGSSS	SPOP	0.9903	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	515:519	AGSSS	SPOP	0.9666	More...
Q16644	MAP kinase-activated protein kinase 3	DEG_SPOP_SBC_1	370:374	AGSSS	SPOP	0.8767	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SPOP_SBC_1	792:796	AGSSS	SPOP	0.987	More...
Q71RG4	Transmembrane and ubiquitin-like domain-containing protein 2	DEG_SPOP_SBC_1	150:154	AGSSS	SPOP	0.9638	More...
Q7Z2Z1	Treslin	DEG_SPOP_SBC_1	1696:1700	AGSSS	SPOP	0.9847	More...
Q86VE0	Myb-related transcription factor, partner of profilin	DEG_SPOP_SBC_1	174:178	AGSSS	SPOP	0.9993	More...
Q86YZ3	Hornerin	DEG_SPOP_SBC_1	511:515	AGSSS	SPOP	0.9551	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	257:261	AGSSS	SPOP	0.982	More...
Q8N3F8	MICAL-like protein 1	DEG_SPOP_SBC_1	334:338	AGSSS	SPOP	0.9856	More...
Q8TBC5	Zinc finger and SCAN domain-containing protein 18	DEG_SPOP_SBC_1	142:146	AGSSS	SPOP	0.9968	More...
Q92831	Histone acetyltransferase KAT2B	DEG_SPOP_SBC_1	408:412	AGSSS	SPOP	0.9856	More...
Q96A65	Exocyst complex component 4	DEG_SPOP_SBC_1	250:254	AGSSS	SPOP	0.9981	More...
Q96QT4	Transient receptor potential cation channel subfamily M member 7	DEG_SPOP_SBC_1	1348:1352	AGSSS	SPOP	0.9981	More...
Q9BX10	GTP-binding protein 2	DEG_SPOP_SBC_1	30:34	AGSSS	SPOP	0.9919	More...
Q9H2E6	Semaphorin-6A	DEG_SPOP_SBC_1	370:374	AGSSS	SPOP	0.9534	More...
Q9HCH0	Nck-associated protein 5-like	DEG_SPOP_SBC_1	1242:1246	AGSSS	SPOP	0.9928	More...
Q9P267	Methyl-CpG-binding domain protein 5	DEG_SPOP_SBC_1	546:550	AGSSS	SPOP	0.9719	More...
Q9UGC6	Regulator of G-protein signaling 17	DEG_SPOP_SBC_1	204:208	AGSSS	SPOP	0.6802	More...
Q9UHB7	AF4/FMR2 family member 4	DEG_SPOP_SBC_1	138:142	AGSSS	SPOP	0.9944	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1376:1380	AGSSS	SPOP	0.9974	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	691:695	AGSSS	SPOP	0.9332	More...
Q9Y238	Deleted in lung and esophageal cancer protein 1	DEG_SPOP_SBC_1	31:35	AGSSS	SPOP	0.5085	More...
Q9Y4C8	Probable RNA-binding protein 19	DEG_SPOP_SBC_1	218:222	AGSSS	SPOP	0.9898	More...
Q9Y4F4	TOG array regulator of axonemal microtubules protein 1	DEG_SPOP_SBC_1	1079:1083	AGSSS	SPOP	0.5095	More...
Q9Y6V0	Protein piccolo	DEG_SPOP_SBC_1	4657:4661	AGSSS	SPOP	0.9198	More...
Q5VWJ9	Sorting nexin-30	DEG_SPOP_SBC_1	25:29	AGSSS	SPOP	0.9861	More...
Q8N806	Putative E3 ubiquitin-protein ligase UBR7	DEG_SPOP_SBC_1	261:265	AGSSS	SPOP	0.9974	More...
Q9BUN1	Protein MENT	DEG_SPOP_SBC_1	132:136	AGSSS	SPOP	0.9943	More...
Q9Y4F5	Centrosomal protein of 170 kDa protein B	DEG_SPOP_SBC_1	1288:1292	AGSSS	SPOP	0.9988	More...
P43362	Melanoma-associated antigen 9	DEG_SPOP_SBC_1	52:56	AGSSS	SPOP	0.9728	More...
Q5SYE7	NHS-like protein 1	DEG_SPOP_SBC_1	1330:1334	AGSSS	SPOP	0.8257	More...
Q6UXY8	Transmembrane channel-like protein 5	DEG_SPOP_SBC_1	138:142	AGSSS	SPOP	0.9985	More...
Q96JM4	Leucine-rich repeat and IQ domain-containing protein 1	DEG_SPOP_SBC_1	1709:1713	AGSSS	SPOP	0.7232	More...
Q9C0I3	Serine-rich coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	493:497	AGSSS	SPOP	0.9651	More...
A8MVX0	Rho guanine nucleotide exchange factor 33	DEG_SPOP_SBC_1	684:688	AGSSS	SPOP	0.9552	More...
Q5VW00	DDB1- and CUL4-associated factor 12-like protein 2	DEG_SPOP_SBC_1	20:24	AGSSS	SPOP	0.9965	More...
Q92628	Uncharacterized protein KIAA0232	DEG_SPOP_SBC_1	295:299	AGSSS	SPOP	0.9697	More...
Q9NQR7	Coiled-coil domain-containing protein 177	DEG_SPOP_SBC_1	185:189	AGSSS	SPOP	0.9844	More...
Q96NJ1	Uncharacterized protein FLJ30774	DEG_SPOP_SBC_1	87:91	AGSSS	SPOP	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AGSSS

Degron related mutations and impact score

Drug responses associated with MBD5 mutations

All proteins holding degron of AGSSS