DegronMD - Q92831(KAT2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R137Q	TCGA-16-0848	GBM	TCGA	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.1111
p.R137Q	TCGA-E9-A2JS	BRCA	TCGA	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.1111
p.R137Q	DO3209	BRCA	ICGC	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.1111
p.R137Q	DO12196	GBM	ICGC	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.1111
p.S131N	TCGA-A6-6781	COAD	TCGA	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.2778
p.S131N	DO8447	COAD	ICGC	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.2778
p.N113S	TCGA-CA-6717	COAD	TCGA	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.1111
p.N113S	DO8264	COAD	ICGC	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.1111
p.G409W	TCGA-D3-A3CB	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	408:412	Mutation altering degron motif	0.6714
p.G409W	DO47386	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	408:412	Mutation altering degron motif	0.6714
p.A417T	TCGA-E6-A1LX	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	408:412	Mutation rewiring degron network	0.1944
p.A417T	DO41020	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	408:412	Mutation rewiring degron network	0.1944
p.R137W	TCGA-F5-6814	READ	TCGA	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.1111
p.R137W	DO36556	READ	ICGC	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.1111
p.S400L	TCGA-FW-A3R5	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	408:412	Mutation rewiring degron network	0.1111
p.S400L	DO37406	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	408:412	Mutation rewiring degron network	0.1111
p.S117P	DO48406	BLCA	ICGC	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation blocking phosphorylation signal	0.6667
p.A408T	DO217939	BRCA	ICGC	AGSSS	DEG_SPOP_SBC_1	408:412	Mutation altering degron motif	0.7139
p.A408T	ACH-000937	Leukemia	CCLE	AGSSS	DEG_SPOP_SBC_1	408:412	Mutation altering degron motif	0.7139
p.P114H	DO228901	LICA	ICGC	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.1389
p.E422K	SIDM00095	Glioblastoma	GDSC	AGSSS	DEG_SPOP_SBC_1	408:412	Mutation rewiring degron network	0.0556
p.E422K	ACH-000504	Brain Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	408:412	Mutation rewiring degron network	0.0556
p.E422K	SNB75	central nervous system	COSMIC	AGSSS	DEG_SPOP_SBC_1	408:412	Mutation rewiring degron network	0.0556
p.T119I	SIDM00562	Breast Carcinoma	GDSC	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation blocking phosphorylation signal	0.7222
p.T119I	ACH-002163	Breast Cancer	CCLE	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation blocking phosphorylation signal	0.7222
p.T119I	MRK-nu-1	breast	COSMIC	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation blocking phosphorylation signal	0.7222
p.T133A	SIDM00217	Colorectal Carcinoma	GDSC	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.2222
p.T133A	ACH-000999	Colon/Colorectal Cancer	CCLE	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.2222
p.T133A	SNU-1040	large intestine	COSMIC	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation rewiring degron network	0.2222
p.D124N	ACH-000918	Leukemia	CCLE	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation altering degron motif	0.5821
p.P121S	ACH-001119	Lymphoma	CCLE	PRADLQQII	DEG_APCC_DBOX_1	121:129	Mutation altering degron motif	0.5641
p.Q405K	ACH-001413	Bladder Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	408:412	Mutation rewiring degron network	0.25
p.G409R	ACH-001518	Endometrial/Uterine Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	408:412	Mutation altering degron motif	0.6457
p.L403I	ACH-001610	Brain Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	408:412	Mutation rewiring degron network	0.1944
p.N407K	ACH-001793	Liposarcoma	CCLE	AGSSS	DEG_SPOP_SBC_1	408:412	Mutation rewiring degron network	0.3056

Kaplan plot for KAT2B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KAT2B

UniProt ID: Q92831

Entrez ID: 8850

Protein name: Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KAT2B in