DegronMD

Uniprot ID: Q92831

Source protein: Histone acetyltransferase KAT2B

Source gene: KAT2B

Class: DEG_APCC_DBOX_1

Location: 121:129

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8374

ASA_SCORE: 79.1333

COIL: 0.4582

CONS_SCORE: 0.285

DSS_SCORE: 0.4983

HELIX: 0.5166

FCONS_SCORE: 0.8332

RIG_SCORE: 0.7809

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R137Q	TCGA-16-0848	GBM	TCGA	PRADLQQII	DEG_APCC_DBOX_1	0.1111
p.R137Q	TCGA-E9-A2JS	BRCA	TCGA	PRADLQQII	DEG_APCC_DBOX_1	0.1111
p.R137Q	DO3209	BRCA	ICGC	PRADLQQII	DEG_APCC_DBOX_1	0.1111
p.R137Q	DO12196	GBM	ICGC	PRADLQQII	DEG_APCC_DBOX_1	0.1111
p.S131N	TCGA-A6-6781	COAD	TCGA	PRADLQQII	DEG_APCC_DBOX_1	0.2778
p.S131N	DO8447	COAD	ICGC	PRADLQQII	DEG_APCC_DBOX_1	0.2778
p.N113S	TCGA-CA-6717	COAD	TCGA	PRADLQQII	DEG_APCC_DBOX_1	0.1111
p.N113S	DO8264	COAD	ICGC	PRADLQQII	DEG_APCC_DBOX_1	0.1111
p.R137W	TCGA-F5-6814	READ	TCGA	PRADLQQII	DEG_APCC_DBOX_1	0.1111
p.R137W	DO36556	READ	ICGC	PRADLQQII	DEG_APCC_DBOX_1	0.1111
p.S117P	DO48406	BLCA	ICGC	PRADLQQII	DEG_APCC_DBOX_1	0.6667
p.P114H	DO228901	LICA	ICGC	PRADLQQII	DEG_APCC_DBOX_1	0.1389
p.T119I	SIDM00562	Breast Carcinoma	GDSC	PRADLQQII	DEG_APCC_DBOX_1	0.7222
p.T119I	ACH-002163	Breast Cancer	CCLE	PRADLQQII	DEG_APCC_DBOX_1	0.7222
p.T119I	MRK-nu-1	breast	COSMIC	PRADLQQII	DEG_APCC_DBOX_1	0.7222
p.T133A	SIDM00217	Colorectal Carcinoma	GDSC	PRADLQQII	DEG_APCC_DBOX_1	0.2222
p.T133A	ACH-000999	Colon/Colorectal Cancer	CCLE	PRADLQQII	DEG_APCC_DBOX_1	0.2222
p.T133A	SNU-1040	large_intestine	COSMIC	PRADLQQII	DEG_APCC_DBOX_1	0.2222
p.D124N	ACH-000918	Leukemia	CCLE	PRADLQQII	DEG_APCC_DBOX_1	0.5821
p.P121S	ACH-001119	Lymphoma	CCLE	PRADLQQII	DEG_APCC_DBOX_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92831	Histone acetyltransferase KAT2B	DEG_APCC_DBOX_1	121:129	PRADLQQII	APC,CDC20,FZR1	0.8374	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons